Toxic hepatitis due to enalapril in childhood

Many therapeutic agents and toxins can produce liver lesions, such as hepatitis, cirrhosis and portal hypertension. It has been reported that 10% of cases of apparent hepatitis are due to drug-induced injury. 1 Drugs produce cytotoxic, cholestatic or mixed forms of acute hepatic injury with features of both hepatocellular and cholestatic jaundice. Up to 25% of cases of fulminant hepatic failure might be the result of adverse reaction to medications. 1

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[3]  E. Calderón,et al.  Fatal Hepatotoxicity Associated with Enalapril , 2001, The Annals of pharmacotherapy.

[4]  C. Ihling,et al.  Acute Liver Failure due to Enalapril , 2000, Herz.

[5]  C. Quílez,et al.  [Hepatoxicity by enalapril]. , 1999, Gastroenterologia y hepatologia.

[6]  E. Hartshorn,et al.  Hepatotoxicity Associated with Angiotensin-Converting Enzyme Inhibitors , 1993, The Annals of pharmacotherapy.

[7]  M. Jurima‐Romet,et al.  Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione. , 1992, Biochemical pharmacology.

[8]  M. Hagley,et al.  Suspected Cross-Reactivity of Enalapril- and Captopril-Induced Hepatotoxicity , 1992, The Annals of pharmacotherapy.

[9]  D. Pessayre,et al.  Fulminant hepatitis after lisinopril administration. , 1990, Gastroenterology.