Physiology-Based Kinetic Modeling of Neuronal Energy Metabolism Unravels the Molecular Basis of NAD(P)H Fluorescence Transients

[1]  S. Bulik,et al.  Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone‐induced Parkinson's disease: a model‐based analysis , 2013, The FEBS journal.

[2]  H. Holzhütter,et al.  Oxygen Consumption Rates during Three Different Neuronal Activity States in the Hippocampal CA3 Network , 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  David A. Boas,et al.  In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH , 2013, Biomedical optics express.

[4]  G. Dienel,et al.  Brain Lactate Metabolism: The Discoveries and the Controversies , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  David Attwell,et al.  Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing , 2012, The Journal of Neuroscience.

[6]  S. Bulik,et al.  Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species , 2012, International journal of cell biology.

[7]  R. Llinás,et al.  Cytosolic Calcium Coordinates Mitochondrial Energy Metabolism with Presynaptic Activity , 2012, The Journal of Neuroscience.

[8]  C. Mathiesen,et al.  Activity-dependent Increases in Local Oxygen Consumption Correlate with Postsynaptic Currents in the Mouse Cerebellum In Vivo , 2011, The Journal of Neuroscience.

[9]  C. Ayata,et al.  Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. , 2011, Journal of biomedical optics.

[10]  H. Holzhütter,et al.  The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model. , 2011, Journal of theoretical biology.

[11]  G. Somjen,et al.  Simultaneous Monitoring of Tissue Po2 and NADH Fluorescence During Synaptic Stimulation and Spreading Depression Reveals a Transient Dissociation between Oxygen Utilization and Mitochondrial Redox State in Rat Hippocampal Slices , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[12]  J. Rillich,et al.  The biphasic NAD(P)H fluorescence response of astrocytes to dopamine reflects the metabolic actions of oxidative phosphorylation and glycolysis , 2010, Journal of neurochemistry.

[13]  C. Shuttleworth,et al.  Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation , 2010, Neurochemistry International.

[14]  N. Secher,et al.  Lactate fuels the human brain during exercise , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[15]  T. Videen,et al.  Cerebral Mitochondrial Metabolism in Early Parkinson's Disease , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[16]  Jakub Otáhal,et al.  Gamma Oscillations and Spontaneous Network Activity in the Hippocampus Are Highly Sensitive to Decreases in pO2 and Concomitant Changes in Mitochondrial Redox State , 2008, The Journal of Neuroscience.

[17]  D. Turner,et al.  Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices , 2007, Journal of neurochemistry.

[18]  Britton Chance,et al.  Oxidation-reduction states of NADH in vivo: from animals to clinical use. , 2007, Mitochondrion.

[19]  P. Magistretti,et al.  Activity‐dependent regulation of energy metabolism by astrocytes: An update , 2007, Glia.

[20]  P. Magistretti,et al.  A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism , 2007, Proceedings of the National Academy of Sciences.

[21]  Avraham Mayevsky,et al.  Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies. , 2007 .

[22]  S. Thayer,et al.  Mitochondrial modulation of Ca2+ -induced Ca2+ -release in rat sensory neurons. , 2006, Journal of neurophysiology.

[23]  Arne Schousboe,et al.  Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. , 2006, Biochemical pharmacology.

[24]  B. Ross,et al.  Noninvasive assessment of the relative roles of cerebral antioxidant enzymes by quantitation of pentose phosphate pathway activity , 1996, Neurochemical Research.

[25]  S. Thayer,et al.  Mitochondrial Modulation of Ca 2-Induced Ca 2-Release in Rat Sensory Neurons , 2006 .

[26]  D. A. Turner,et al.  Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices , 2005, Neuroscience.

[27]  Jakub Otáhal,et al.  Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans. , 2005, Brain : a journal of neurology.

[28]  W. Webb,et al.  Conformational Dependence of Intracellular NADH on Metabolic State Revealed by Associated Fluorescence Anisotropy*♦ , 2005, Journal of Biological Chemistry.

[29]  A. Aubert,et al.  Interaction between Astrocytes and Neurons Studied using a Mathematical Model of Compartmentalized Energy Metabolism , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[30]  Ata Akin,et al.  Modelling of calcium dynamics in brain energy metabolism and Alzheimer's disease , 2005, Comput. Biol. Chem..

[31]  W. Webb,et al.  Neural Activity Triggers Neuronal Oxidative Metabolism Followed by Astrocytic Glycolysis , 2004, Science.

[32]  G. Thews Ein Verfahren zur Bestimmung des O2-Diffusionskoeffizienten, der O2-Leitfähigkeit und des O2-Löslichkeitskoeffizienten im Gehirngewebe , 2004, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[33]  S. Schuchmann,et al.  Coupling of neuronal activity and mitochondrial metabolism as revealed by nad(p)h fluorescence signals in organotypic hippocampal slice cultures of the rat , 2003, Neuroscience.

[34]  S. Schuchmann,et al.  Free radical-mediated cell damage after experimental status epilepticus in hippocampal slice cultures. , 2002, Journal of neurophysiology.

[35]  G. Dienel,et al.  Glucose and lactate metabolism during brain activation , 2001, Journal of neuroscience research.

[36]  R Valabrègue,et al.  Modelling of the Coupling between Brain Electrical Activity and Metabolism , 2001, Acta biotheoretica.

[37]  M. Ward,et al.  Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts , 2000, Trends in Neurosciences.

[38]  H. Shimoda,et al.  Characteristics of monocarboxylates as energy substrates other than glucose in rat brain slices and the effect of selective glial poisoning — a 31P NMR study , 2000, Neuroscience Research.

[39]  A. Rex,et al.  Cortical NADH during pharmacological manipulations of the respiratory chain and spreading depression in vivo , 1999, Journal of neuroscience research.

[40]  L. Sokoloff,et al.  Cerebral Oxygen/Glucose Ratio is Low during Sensory Stimulation and Rises above Normal during Recovery: Excess Glucose Consumption during Stimulation is Not Accounted for by Lactate Efflux from or Accumulation in Brain Tissue , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[41]  V. Sogos,et al.  Subcellular heterogeneity of mitochondrial membrane potential: relationship with organelle distribution and intercellular contacts in normal, hypoxic and apoptotic cells. , 1999, Journal of cell science.

[42]  A. Hudetz,et al.  Blood Flow in the Cerebral Capillary Network: A Review Emphasizing Observations with Intravital Microscopy , 1997, Microcirculation.

[43]  Helmut Kettenmann,et al.  Calcium signalling in glial cells , 1996, Trends in Neurosciences.

[44]  A. J. Hulbert,et al.  Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat. , 1994, Biochimica et biophysica acta.

[45]  M. Duchen,et al.  Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. , 1992, The Biochemical journal.

[46]  R. M. Hays,et al.  ADH-induced depolymerization of F-actin in the toad bladder granular cell: a confocal microscope study. , 1992, The American journal of physiology.

[47]  R. Vannucci,et al.  Cerebral energy metabolism during hypoxia-ischemia and early recovery in immature rats. , 1992, The American journal of physiology.

[48]  P. Bernardi,et al.  The K+ conductance of the inner mitochondrial membrane. A study of the inducible uniport for monovalent cations. , 1991, The Journal of biological chemistry.

[49]  H. O. Spivey,et al.  Metabolic compartmentation. , 1989, BioEssays : news and reviews in molecular, cellular and developmental biology.

[50]  A. Schurr,et al.  Lactate-supported synaptic function in the rat hippocampal slice preparation. , 1988, Science.

[51]  G. Brown,et al.  Proton/electron stoichiometry of mitochondrial complex I estimated from the equilibrium thermodynamic force ratio. , 1988, The Biochemical journal.

[52]  G. Krishnamoorthy,et al.  Non-ohmic proton conductance of mitochondria and liposomes. , 1984, Biochemistry.

[53]  B Chance,et al.  Pyridine Nucleotide as an Indicator of the Oxygen Requirements for Energy‐Linked Functions of Mitochondria , 1976, Circulation research.

[54]  Britton Chance,et al.  Metabolic responses of the awake cerebral cortex to anoxia hypoxia spreading depression and epileptiform activity , 1975, Brain Research.

[55]  P. Lipton,et al.  Effects of membrane depolarization on nicotinamide nucleotide fluorescence in brain slices. , 1973, The Biochemical journal.

[56]  L. Sokoloff Metabolism of ketone bodies by the brain. , 1973, Annual review of medicine.

[57]  C. Nicholson,et al.  Calcium Transient in Presynaptic Terminal of Auid Giant Synapse: Detection with Aequorin , 1972, Science.

[58]  G. Thews [A method for determination of oxygen diffusion coefficients, oxygen conductivity and oxygen solubility coefficients in brain tissue]. , 1960, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere.