Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Background and Aim:  Hepatitis B virus (HBV) genotype C has a more severe pathogenesis than genotype B in Japan. We retrospectively investigated the relationship between HBV genotype and the core promoter (CP) (nt 1762 and 1764) and precore (PreC) (nt 1896) mutations of the HBV genome.

[1]  D. Shafritz,et al.  Analysis of Liver Disease, Nuclear HBcAg, Viral Replication, and Hepatitis B Virus DNA in Liver and Serum of HBcAg Vs. Anti‐HBe Positive Carriers of Hepatitis B Virus , 2007, Hepatology.

[2]  Ding‐Shinn Chen,et al.  Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. , 2003, Gastroenterology.

[3]  M. Mizokami,et al.  Preponderance of hepatitis B virus genotype B contributes to a better prognosis of chronic HBV infection in Okinawa, Japan , 2002, Journal of medical virology.

[4]  S. Kashiwagi,et al.  Clinical outcomes of hepatitis B virus (HBV) genotypes B and C in Japanese patients with chronic HBV infection. , 2002, The American journal of tropical medicine and hygiene.

[5]  F. Sugauchi,et al.  Hepatitis B Virus of Genotype B with or without Recombination with Genotype C over the Precore Region plus the Core Gene , 2002, Journal of Virology.

[6]  F. Sugauchi,et al.  Determination of hepatitis B virus genotype G by polymerase chain reaction with hemi-nested primers. , 2001, Journal of virological methods.

[7]  Makoto Nakanishi,et al.  Hepatitis B Virus Genotype Distribution among Chronic Hepatitis B Virus Carriers in Shanghai, China , 2001, Intervirology.

[8]  T. Okanoue,et al.  A case‐control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C , 2001, Hepatology.

[9]  P. Holland,et al.  Differentiation of hepatitis B virus genotypes D and E by ELISA using monoclonal antibodies to epitopes on the preS2-region product. , 2000, Journal of virological methods.

[10]  Ding‐Shinn Chen,et al.  Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. , 2000, Gastroenterology.

[11]  H. Okamoto,et al.  Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product. , 1999, Journal of virological methods.

[12]  S. Kashiwagi,et al.  Hepatitis B surface antigen disappearance and hepatitis B surface antigen subtype: a prospective, long-term, follow-up study of Japanese residents of Okinawa, Japan with chronic hepatitis B virus infection. , 1999, The American journal of tropical medicine and hygiene.

[13]  C. Hannoun,et al.  Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers. , 1999, The Journal of infectious diseases.

[14]  O. Yokosuka,et al.  Detection of mutations in the enhancer 2/core promoter region of hepatitis B virus in patients with chronic hepatitis B virus infection: Comparison with mutations in precore and core regions in relation to clinical status , 1999, Journal of medical virology.

[15]  P. Tangkijvanich,et al.  Genotypes and subtypes of hepatitis B virus in Thailand. , 1998, The Southeast Asian journal of tropical medicine and public health.

[16]  M Lindh,et al.  Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus--large-scale analysis using a new genotyping method. , 1997, The Journal of infectious diseases.

[17]  S. Günther,et al.  Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease , 1996, Journal of virology.

[18]  M. Buti,et al.  Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations , 1995, Hepatology.

[19]  S. Mishiro,et al.  The precore/core promoter mutant (T1762A1764) of hepatitis B virus: clinical significance and an easy method for detection. , 1995, The Journal of general virology.

[20]  D. Persing,et al.  Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B. , 1995, Gastroenterology.

[21]  F Tsuda,et al.  Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen , 1994, Journal of virology.

[22]  H. Okamoto,et al.  Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease , 1994, Journal of medical virology.

[23]  U. Akarca,et al.  Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  S. Kashiwagi,et al.  HBsAg subtypes among HBsAg carriers in Okinawa, Japan. Evidence of an important relationship in seroconversion from HBeAg to anti-HBe. , 1994, The Journal of infection.

[25]  A. Couroucé,et al.  Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. , 1994, Virology.

[26]  Q. Zhang,et al.  Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region , 1993, Journal of virology.

[27]  E. Domingo,et al.  Viral genetic variation: hepatitis B virus as a clinical example , 1993, The Lancet.

[28]  H. Will,et al.  Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[29]  F Tsuda,et al.  Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen , 1990, Journal of virology.

[30]  H. Thomas,et al.  MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION , 1989, The Lancet.

[31]  P. Wingfield,et al.  Comparative immunogenicity of hepatitis B virus core and E antigens. , 1988, Journal of immunology.

[32]  H. Sakugawa,et al.  Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. , 1988, The Journal of general virology.

[33]  W. Gerlich,et al.  Formation of transmembraneous hepatitis B e-antigen by cotranslational in vitro processing of the viral precore protein. , 1988, Virology.

[34]  H. Nomura,et al.  Age‐Specific Prevalence of Hepatitis B e Antigen (HBeAg) and Antibody to HBeAg (Anti‐HBe) among Asymptomatic Hepatitis B Surface Antigen (HBsAg) Carriers in Okinawa and Kyushu, Japan , 1986, Microbiology and immunology.

[35]  F. Callea,et al.  Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBe. , 1986, Gastroenterology.

[36]  P. Winter,et al.  MORTALITY OF HEPATITIS B POSITIVE BLOOD DONORS IN ENGLAND AND WALES , 1985, The Lancet.

[37]  H. Nomura,et al.  Transmission of hepatitis B virus among siblings. , 1984, American journal of epidemiology.

[38]  J. Summers,et al.  Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate , 1982, Cell.

[39]  Yoshiyuki Suzuki,et al.  Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C , 2002, Journal of Gastroenterology.

[40]  M. Rugge,et al.  Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. , 1980, Gastroenterology.