Nucleophilic rhodanine, thiazolidine-2,4-dione and thiazol-4(5H)-one substrates in asymmetric reactions

Substituted rhodanines, thiazolidine-2,4-diones and thiazol-4(5H)-ones as nucleophilic substrates have attracted great attention in asymmetric reactions in the past six years due to their high impact in medicinal and pharmaceutical importance. The current review provides a cursory overview of the synthetic methods developed to access the rhodanine, thiazolidine-2,4-dione and thiazol-4(5H)-one substrates and a summary of their applications in catalytic asymmetric reactions to synthesize a broad range of differently substituted chiral derivatives of the corresponding substrates with tertiary/quaternary stereogenic centres.