Clinically applicable CD34+-derived blood dendritic cell subsets exhibit key subset-specific features and potently boost anti-tumor T and NK cell responses

[1]  Z. Shao,et al.  Natural killer cells in cancer biology and therapy , 2020, Molecular Cancer.

[2]  R. Medzhitov,et al.  Harnessing innate immunity in cancer therapy , 2019, Nature.

[3]  S. Della Bella,et al.  Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells , 2019, Front. Immunol..

[4]  R. Noubade,et al.  Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity , 2019, Front. Immunol..

[5]  G. Coukos,et al.  The clinical application of cancer immunotherapy based on naturally circulating dendritic cells , 2019, Journal of Immunotherapy for Cancer.

[6]  C. Heirman,et al.  The Vacuolar Pathway of Long Peptide Cross-Presentation Can Be TAP Dependent , 2019, The Journal of Immunology.

[7]  B. Reizis Plasmacytoid Dendritic Cells: Development, Regulation, and Function , 2019, Immunity.

[8]  M. Kester,et al.  Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy , 2018, Oncoimmunology.

[9]  A. Villani,et al.  Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity , 2018, Cell reports.

[10]  J. Borst,et al.  CD4+ T cell help in cancer immunology and immunotherapy , 2018, Nature Reviews Immunology.

[11]  Sven Burgdorf,et al.  Current Concepts of Antigen Cross-Presentation , 2018, Front. Immunol..

[12]  S. P. Sittig,et al.  Naturally produced type I IFNs enhance human myeloid dendritic cell maturation and IL-12p70 production and mediate elevated effector functions in innate and adaptive immune cells , 2018, Cancer Immunology, Immunotherapy.

[13]  M. Merad,et al.  Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells , 2018, Cell reports.

[14]  Matthew Collin,et al.  Human dendritic cell subsets: an update , 2018, Immunology.

[15]  B. Becher,et al.  Restoration of Natural Killer Cell Antimetastatic Activity by IL12 and Checkpoint Blockade. , 2017, Cancer research.

[16]  D. Stroncek,et al.  Sources of Hematopoietic Stem and Progenitor Cells and Methods to Optimize Yields for Clinical Cell Therapy. , 2017, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[17]  N. Hacohen,et al.  Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors , 2017, Science.

[18]  F. Klauschen,et al.  CD8+ T Cells Orchestrate pDC‐XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming , 2017, Immunity.

[19]  M. Kester,et al.  Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo , 2017, Oncoimmunology.

[20]  K. Thielemans,et al.  Long-Peptide Cross-Presentation by Human Dendritic Cells Occurs in Vacuoles by Peptide Exchange on Nascent MHC Class I Molecules , 2016, The Journal of Immunology.

[21]  C. Figdor,et al.  Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells , 2015, Clinical Cancer Research.

[22]  Eric O Long,et al.  NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors , 2015, The Journal of Immunology.

[23]  Michael Y. Gerner,et al.  Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions , 2015, Cell.

[24]  A. Tosti,et al.  Haploidentical hematopoietic transplantation from KIR ligand-mismatched donors with activating KIRs reduces nonrelapse mortality. , 2015, Blood.

[25]  E. Segura,et al.  The Known Unknowns of the Human Dendritic Cell Network , 2015, Front. Immunol..

[26]  Matthew R Trendowski,et al.  Using Cytochalasins to Improve Current Chemotherapeutic Approaches , 2015, Anti-cancer agents in medicinal chemistry.

[27]  Even Fossum,et al.  Human XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells , 2014, The Journal of Immunology.

[28]  Z. Berneman,et al.  Clinical use of dendritic cells for cancer therapy. , 2014, The Lancet. Oncology.

[29]  T. Radstake,et al.  The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. , 2014, Stem cells and development.

[30]  H. Bluyssen,et al.  A type I IFN–Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors , 2013, The Journal of experimental medicine.

[31]  W. Oyen,et al.  Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients. , 2013, Cancer research.

[32]  T. Elliott,et al.  The pathway of cross‐presentation is influenced by the particle size of phagocytosed antigen , 2012, Immunology.

[33]  Y. Ishigatsubo,et al.  The impact of the dose of natural killer cells in the graft on severe acute graft-versus-host disease after unrelated bone marrow transplantation. , 2012, Leukemia research.

[34]  C. Figdor,et al.  The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. , 2012, Blood.

[35]  C. Münz,et al.  Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals , 2011, Cellular and Molecular Life Sciences.

[36]  C. Dutertre,et al.  The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+ dendritic cells , 2010, The Journal of experimental medicine.

[37]  Anna M. Keller,et al.  Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells , 2010, The Journal of experimental medicine.

[38]  P. Rod Dunbar,et al.  Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens , 2010, The Journal of experimental medicine.

[39]  P. Kloetzel,et al.  Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells , 2010, The Journal of experimental medicine.

[40]  M. V. van Loenen,et al.  Optimization of the HA-1-specific T-cell receptor for gene therapy of hematologic malignancies , 2009, Haematologica.

[41]  M. Manz,et al.  The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. , 2009, Blood.

[42]  R. Storb,et al.  What is the role for donor natural killer cells after nonmyeloablative conditioning? , 2009, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[43]  M. Martinetti,et al.  Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity. , 2009, Blood.

[44]  A. Barrett Understanding and harnessing the graft‐versus‐leukaemia effect , 2008, British journal of haematology.

[45]  Eric Vivier,et al.  Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling , 2008, Genome Biology.

[46]  Marcela R. Uribe,et al.  Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia , 2007, Leukemia.

[47]  A. Diefenbach,et al.  Dendritic cells prime natural killer cells by trans-presenting interleukin 15. , 2007, Immunity.

[48]  C. Liu,et al.  Plasmacytoid Dendritic Cells Synergize with Myeloid Dendritic Cells in the Induction of Antigen-Specific Antitumor Immune Responses , 2007, The Journal of Immunology.

[49]  L. Zitvogel,et al.  NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. , 2004, Blood.

[50]  F. Appelbaum,et al.  Haematopoietic cell transplantation as immunotherapy , 2001, Nature.

[51]  S. Porcelli,et al.  CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen , 1992, Nature.

[52]  M. Dalod,et al.  In Vitro Generation of Human XCR1(+) Dendritic Cells from CD34(+) Hematopoietic Progenitors. , 2016, Methods in molecular biology.

[53]  Even Fossum,et al.  Human XCR 1 + Dendritic Cells Derived In Vitro from CD 34 + Progenitors Closely Resemble Blood Dendritic Cells , Including Their Adjuvant Responsiveness , Contrary to Monocyte-Derived Dendritic Cells , 2014 .