Safety and immunogenicity in animals of subunit influenza vaccine given intranasally with mutants of Escherichia coli heat-labile enterotoxin (LT)

[1]  S. Mossad Demystifying FluMist, a new intranasal, live influenza vaccine. , 2003, Cleveland Clinic journal of medicine.

[2]  R. Walker,et al.  Safety and immunogenicity of a live-attenuated influenza vaccine blended and filled at two manufacturing facilities. , 2003, Vaccine.

[3]  M. Giuliani,et al.  Enhancement of Protective Efficacy following Intranasal Immunization with Vaccine Plus a Nontoxic LTK63 Mutant Delivered with Nanoparticles , 2002, Infection and Immunity.

[4]  J. Mcghee,et al.  A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. , 2002, Vaccine.

[5]  M. Singh,et al.  A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[6]  J. Donnelly,et al.  Potency of a genetically detoxified mucosal adjuvant derived from the heat-labile enterotoxin of Escherichia coli (LTK63) is not adversely affected by the presence of preexisting immunity to the adjuvant. , 2001, The Journal of infectious diseases.

[7]  G. Dougan,et al.  Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins. , 1999, Immunology today.

[8]  G. Ott,et al.  Intranasal Immunization of Mice with Influenza Vaccine in Combination with the Adjuvant LT-R72 Induces Potent Mucosal and Serum Immunity Which Is Stronger than That with Traditional Intramuscular Immunization , 1999, Infection and Immunity.

[9]  G. Dougan,et al.  Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity , 1998, The Journal of experimental medicine.

[10]  R. Rappuoli,et al.  The adjuvant effect of a non‐toxic mutant of heat‐labile enterotoxin of Escherichia coli for the induction of measles virus‐specific CTL responses after intranasal co‐immunization with a synthetic peptide , 1996, Immunology.

[11]  J. Kraehenbuhl,et al.  Epithelial M Cells: Gateways for Mucosal Infection and Immunization , 1996, Cell.

[12]  J. Kraehenbuhl,et al.  Antigen sampling across epithelial barriers and induction of mucosal immune responses. , 1996, Annual review of immunology.

[13]  M. Levine,et al.  New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development. , 1983, Microbiological reviews.