Abolition by omeprazole of aspirin induced gastric mucosal injury in man.

This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to latin square. It was concluded that profound acid suppression can prevent aspirin induced gastric mucosal injury in normal subjects. This approach may prevent the development of peptic ulcers and their complications in patients taking aspirin and other non-steroidal anti-inflammatory drugs.

[1]  C. Hawkey,et al.  Enhanced gastric mucosal bleeding with doses of aspirin used for prophylaxis and its reduction by ranitidine. , 1989, British journal of clinical pharmacology.

[2]  C. Hawkey,et al.  Use of microbleeding and an ultrathin endoscope to assess gastric mucosal protection by famotidine. , 1989, Gastroenterology.

[3]  S. Roth,et al.  PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL , 1988, The Lancet.

[4]  G. Tildesley,et al.  Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. , 1988, BMJ.

[5]  W. Creutzfeldt,et al.  Long-term omeprazole treatment in man: effects on gastric endocrine cell populations. , 1988, Digestion.

[6]  R. Pounder,et al.  Twenty‐four‐hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia , 1987, Alimentary pharmacology & therapeutics.

[7]  C. Hawkey,et al.  Reduction by enprostil of aspirin-induced blood loss from human gastric mucosa. , 1986, The American journal of medicine.

[8]  S. Clissold,et al.  Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome. , 1986, Drugs.

[9]  M. Langman,et al.  NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCER , 1986, The Lancet.

[10]  H. Larsson,et al.  Effect of Omeprazole on Gastric Mucosal Blood Flow in the Rat , 1986 .

[11]  H. Mattsson.  Protective Effects of Omeprazole in the Gastric Mucosa , 1986 .

[12]  C. Hawkey,et al.  Strategies for preventing aspirin-induced gastric bleeding. , 1986, Scandinavian journal of gastroenterology. Supplement.

[13]  J. Wallace,et al.  Effects of acid on the basal lamina of the rat stomach and duodenum , 1986, Virchows Archiv. B, Cell pathology including molecular pathology.

[14]  C. Hawkey,et al.  Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease, or treatment? , 1985, Gastroenterology.

[15]  J. Pain,et al.  Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. , 1985, Gut.

[16]  D. Hetzel,et al.  Omeprazole inhibition of nocturnal gastric secretion in patients with duodenal ulcer. , 1984, British journal of clinical pharmacology.

[17]  H. Mattsson,et al.  Omeprazole provides protection against experimentally induced gastric mucosal lesions. , 1983, European journal of pharmacology.

[18]  T. Brzozowski,et al.  Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats. , 1983, Digestion.

[19]  P. Johnson.  Gastrointestinal Consequences of Treatment with Drugs in Elderly Patients , 1982, Journal of the American Geriatrics Society.

[20]  D. Spiegelhalter,et al.  Aspirin, paracetamol, and haematemesis and melaena. , 1982, Gut.

[21]  J. Wallace,et al.  The roles of ethanol and of acid in the production of gastric mucosal erosions in rats , 1981, Virchows Archiv. B, Cell pathology including molecular pathology.

[22]  H. Davenport.  Gastric mucosal hemorrhage in dogs. Effects of acid, aspirin, and alcohol. , 1969, Gastroenterology.

[23]  A. H. Douthwaite,et al.  GASTROSCOPIC OBSERVATION OF THE EFFECT OF ASPIRIN AND CERTAIN OTHER SUBSTANCES ON THE STOMACH , 1938 .