High visible light sensitive MoS2 ultrathin nanosheets for photoelectrochemical biosensing.

For the purpose of effectively utilizing the visible light, photoelectrochemical (PEC) detection represents a unique detection signal and different energy form of the excitation source. In this work, ultrathin MoS2 nanosheets with narrow band gap were successfully fabricated by a facile C3N4 sacrificial template assisted thermolytical approach. Upon immobilizing glucose oxidase, excellent photocatalytic activity towards glucose is achieved in neutral buffer solution. As a novel visible light sensitive photocatalytic material, ultrathin MoS2 nanosheets present a detection limit of ~0.61nM, which is much lower than those with the similar configurations reported previously. Based on the excellent anti-interference property, the feasibility of applying the proposed sensor to determine glucose in human serum is further demonstrated. This work provides new insight into the fabrication of promising visible light sensitive two-dimensional layered transition-metal chalcogenides nanostructures for construction of photoelectrochemical biosensors.

[1]  Gengfeng Zheng,et al.  Sensitive enzymatic glucose detection by TiO2 nanowire photoelectrochemical biosensors , 2014 .

[2]  Yu Zhang,et al.  Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. , 2007, Nature nanotechnology.

[3]  Yang Xu,et al.  Double-Stranded DNA Single-Walled Carbon Nanotube Hybrids for Optical Hydrogen Peroxide and Glucose Sensing , 2007 .

[4]  H. N. Lim,et al.  Utilization of reduced graphene oxide/cadmium sulfide-modified carbon cloth for visible-light-prompt photoelectrochemical sensor for copper (II) ions. , 2016, Journal of hazardous materials.

[5]  Zhao Yue,et al.  Quantum-dot-based photoelectrochemical sensors for chemical and biological detection. , 2013, ACS applied materials & interfaces.

[6]  A. Fujishima,et al.  Photoelectrochemical biosensors: New insights into promising photoelectrodes and signal amplification strategies , 2015 .

[7]  Bo Chen,et al.  Au nanoparticle-modified MoS2 nanosheet-based photoelectrochemical cells for water splitting. , 2014, Small.

[8]  Chunhai Fan,et al.  Direct electrochemistry of glucose oxidase and a biosensor for glucose based on a glass carbon electrode modified with MoS2 nanosheets decorated with gold nanoparticles , 2014, Microchimica Acta.

[9]  L. C. Clark,et al.  ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY , 1962 .

[10]  Itamar Willner,et al.  Acetylcholine esterase-labeled CdS nanoparticles on electrodes: photoelectrochemical sensing of the enzyme inhibitors. , 2003, Journal of the American Chemical Society.

[11]  Joseph Wang.  Electrochemical glucose biosensors. , 2008, Chemical reviews.

[12]  Lihua Zhu,et al.  Sensitive fluorescent probes for determination of hydrogen peroxide and glucose based on enzyme-immobilized magnetite/silica nanoparticles , 2009, Analytical and bioanalytical chemistry.

[13]  Huafeng Yang,et al.  Direct electrochemistry of glucose oxidase and biosensing for glucose based on graphene. , 2009, Analytical chemistry.

[14]  Qing Hua Wang,et al.  Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. , 2012, Nature nanotechnology.

[15]  Eugenii Katz,et al.  Improving enzyme–electrode contacts by redox modification of cofactors , 1995, Nature.

[16]  Ting Zhang,et al.  Ni/CdS/TiO2 nanotube array heterostructures for high performance photoelectrochemical biosensing , 2015 .

[17]  Gengfeng Zheng,et al.  Surface plasmon resonance enhanced real-time photoelectrochemical protein sensing by gold nanoparticle-decorated TiO₂ nanowires. , 2014, Analytical chemistry.

[18]  Junhong Chen,et al.  Constructing 2D Porous Graphitic C3N4 Nanosheets/Nitrogen‐Doped Graphene/Layered MoS2 Ternary Nanojunction with Enhanced Photoelectrochemical Activity , 2013, Advanced materials.

[19]  Xiaoling Yang,et al.  Photoelectrochemical glucose biosensor incorporating CdS nanoparticles , 2009 .

[20]  Sang Yun Lee,et al.  Synergistic metal-metal oxide nanoparticles supported electrocatalytic graphene for improved photoelectrochemical glucose oxidation. , 2014, ACS applied materials & interfaces.

[21]  Hongwei Song,et al.  Zinc oxide inverse opal electrodes modified by glucose oxidase for electrochemical and photoelectrochemical biosensor. , 2014, Biosensors & bioelectronics.

[22]  Ho Won Jang,et al.  Performances of Liquid‐Exfoliated Transition Metal Dichalcogenides as Hole Injection Layers in Organic Light‐Emitting Diodes , 2015 .

[23]  Zoraida P. Aguilar,et al.  A gold@silica core-shell nanoparticle-based surface-enhanced Raman scattering biosensor for label-free glucose detection. , 2014, Analytica chimica acta.

[24]  Wenbo Song,et al.  High-quality phosphorus-doped MoS2 ultrathin nanosheets with amenable ORR catalytic activity. , 2015, Chemical communications.

[25]  A. Fujishima,et al.  Simultaneous glucose sensing and biohydrogen evolution from direct photoelectrocatalytic glucose oxidation on robust Cu₂O-TiO₂ electrodes. , 2014, Physical chemistry chemical physics : PCCP.

[26]  Qiang Zhao,et al.  Silicon nanotube array/gold electrode for direct electrochemistry of cytochrome c. , 2007, The journal of physical chemistry. B.

[27]  S. Dong,et al.  The direct electron transfer of glucose oxidase and glucose biosensor based on carbon nanotubes/chitosan matrix. , 2005, Biosensors & bioelectronics.