The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.

[1]  L. Subrahmanyan,et al.  Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome , 2013, Human mutation.

[2]  R. Malekzadeh,et al.  LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. , 2013, Cell metabolism.

[3]  F. Tinahones,et al.  Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations , 2012, PloS one.

[4]  A. Soukas,et al.  Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2* , 2012, The Journal of Biological Chemistry.

[5]  M. Hall,et al.  Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. , 2012, Cell metabolism.

[6]  G. Maurer,et al.  Premature myocardial infarction is associated with low serum levels of Wnt-1. , 2012, Atherosclerosis.

[7]  A. Sonntag,et al.  A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation , 2012, Science Signaling.

[8]  G. Go,et al.  LRP6 Protein Regulates Low Density Lipoprotein (LDL) Receptor-mediated LDL Uptake* , 2011, The Journal of Biological Chemistry.

[9]  R. Moon,et al.  Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 , 2011, Nature Structural &Molecular Biology.

[10]  J. Gutkind,et al.  Modulation of canonical Wnt signaling by the extracellular matrix component biglycan , 2011, Proceedings of the National Academy of Sciences.

[11]  Derek W. Yecies,et al.  Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. , 2011, Cell metabolism.

[12]  D. Sabatini,et al.  An Emerging Role of mTOR in Lipid Biosynthesis , 2009, Current Biology.

[13]  N. Samani,et al.  A Common Variant in Low-Density Lipoprotein Receptor–Related Protein 6 Gene (LRP6) Is Associated With LDL-Cholesterol , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[14]  K. Adeli,et al.  LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[15]  H. Erfle,et al.  Identification of cholesterol-regulating genes by targeted RNAi screening. , 2009, Cell metabolism.

[16]  N. Sarrafzadegan,et al.  Mutation in EGFP Domain of LDL Receptor-Related Protein 6 Impairs Cellular LDL Clearance , 2008, Circulation research.

[17]  Fiona G. G. Nielsen,et al.  Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells , 2008, Molecular and Cellular Biology.

[18]  J. Sinsheimer,et al.  TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia , 2007, Diabetologia.

[19]  J. Gill,et al.  Development of a novel method to determine very low density lipoprotein kinetics Published, JLR Papers in Press, June 4, 2007. , 2007, Journal of Lipid Research.

[20]  Jayaram Radhakrishnan,et al.  LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors , 2007, Science.

[21]  S. Krauss,et al.  Wnt-mediated Down-regulation of Sp1 Target Genes by a Transcriptional Repressor Sp5* , 2007, Journal of Biological Chemistry.

[22]  Ximing Du,et al.  Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis. , 2006, Molecular biology of the cell.

[23]  C. Darimont,et al.  Liver X receptor preferentially activates de novo lipogenesis in human preadipocytes. , 2006, Biochimie.

[24]  K. Lindor,et al.  Nonalcoholic fatty liver disease , 2005, Canadian Medical Association Journal.

[25]  J. Oram,et al.  LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1 Published, JLR Papers in Press, February 16, 2004. DOI 10.1194/jlr.M400011-JLR200 , 2004, Journal of Lipid Research.

[26]  E. Petricoin,et al.  Trapping radioactive carbon dioxide during cellular metabolic assays under standard culture conditions: description of a unique gas-capturing device. , 2004, Journal of biochemical and biophysical methods.

[27]  S. Hampson,et al.  Using DNA Microarray to Identify Sp1 as a Transcriptional Regulatory Element of Insulin-Like Growth Factor 1 in Cardiac Muscle Cells , 2003, Circulation research.

[28]  J. Goldstein,et al.  Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  R. Aebersold,et al.  Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER , 2002, Cell.

[30]  P. Angulo,et al.  Nonalcoholic fatty liver disease. , 2002, Revista de gastroenterologia de Mexico.

[31]  L. Phillips,et al.  Physiological concentrations of insulin promote binding of nuclear proteins to the insulin-like growth factor I gene. , 2001, Endocrinology.

[32]  L. Phillips,et al.  Involvement of Sp1 in the transcriptional regulation of the rat insulin-like growth factor-1 gene , 2000, Molecular and Cellular Endocrinology.

[33]  X. Hua,et al.  Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein , 1996, Cell.

[34]  C. Kahn,et al.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.

[35]  W. R. Morrison,et al.  PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. , 1964, Journal of lipid research.

[36]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[37]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[38]  C. Drevon,et al.  Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study. , 2011, Atherosclerosis.