Traffic-related Air Pollution and Attention in Primary School Children

Background: Although air pollution’s short-term effects are well understood to be marked and preventable, its acute neuropsychological effects have, to our knowledge, not yet been studied. We aim to examine the association between daily variation in traffic-related air pollution and attention. Methods: We conducted a follow-up study from January 2012 to March 2013 in 2,687 school children from 265 classrooms in 39 schools in Barcelona (Catalonia, Spain). We assessed four domains of children’s attention processes every 3 months over four repeated visits providing a total of 10,002 computerized tests on 177 different days using the child Attention Network test (ANT). Ambient daily levels of nitrogen dioxide (NO2) and elemental carbon (EC) in particulate matter <2.5 µm (PM2.5) filters were measured at a fixed air quality background monitoring station and in schools. Results: Daily ambient levels of both NO2 and EC were negatively associated with all attention processes (e.g., children in the bottom quartile of daily exposure to ambient NO2 levels had a 14.8 msecond [95% confidence interval, 11.2, 18.4] faster response time than those in the top quartile, which was equivalent to a 1.1-month [0.84, 1.37] retardation in the natural developmental improvement in response speed with age). Similar findings were observed after adjusting for the average indoor (classroom) levels of pollutants. Associations for EC were similar to those for NO2 and robust to several sensitivity analyses. Conclusions: The short-term association of traffic-related air pollutants with fluctuations in attention adds to the evidence that air pollution may have potential harmful effects on neurodevelopment. See video abstract at, http://links.lww.com/EDE/B158.

[1]  Mathilde Pascal,et al.  Trends of nitrogen oxides in ambient air in nine European cities between 1999 and 2010 , 2015 .

[2]  J. Sunyer,et al.  Air Pollution and Neuropsychological Development: A Review of the Latest Evidence. , 2015, Endocrinology.

[3]  Wei Yan,et al.  Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain. , 2015, Environmental research.

[4]  Mar Viana,et al.  Outdoor infiltration and indoor contribution of UFP and BC, OC, secondary inorganic ions and metals in PM2.5 in schools , 2015 .

[5]  Mar Viana,et al.  Association between Traffic-Related Air Pollution in Schools and Cognitive Development in Primary School Children: A Prospective Cohort Study , 2015, PLoS medicine.

[6]  J. Sunyer,et al.  Sources of indoor and outdoor PM2.5 concentrations in primary schools. , 2014, The Science of the total environment.

[7]  J. Sunyer,et al.  Child exposure to indoor and outdoor air pollutants in schools in Barcelona, Spain. , 2014, Environment international.

[8]  J. Sunyer,et al.  The n-back test and the attentional network task as measures of child neuropsychological development in epidemiological studies. , 2014, Neuropsychology.

[9]  S. Adar,et al.  Estimating acute air pollution health effects from cohort study data , 2014, Biometrics.

[10]  P. Landrigan,et al.  Neurobehavioural effects of developmental toxicity , 2014, The Lancet Neurology.

[11]  Bert Brunekreef,et al.  Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project. , 2013, Environmental science & technology.

[12]  Luc Int Panis,et al.  Negative effects of ultrafine particle exposure during forced exercise on the expression of Brain-Derived Neurotrophic Factor in the hippocampus of rats , 2012, Neuroscience.

[13]  Rosalind J Wright,et al.  The outdoor air pollution and brain health workshop. , 2012, Neurotoxicology.

[14]  W. Fisk,et al.  Is CO2 an Indoor Pollutant? Direct Effects of Low-to-Moderate CO2 Concentrations on Human Decision-Making Performance , 2012, Environmental health perspectives.

[15]  N. Sang,et al.  In vivo screening to determine neurological hazards of nitrogen dioxide (NO2) using Wistar rats. , 2012, Journal of hazardous materials.

[16]  S. Rajagopalan,et al.  Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology , 2011, Molecular Psychiatry.

[17]  R. Harrison,et al.  New considerations for PM, Black Carbon and particle number concentration for air quality monitoring across different European cities , 2011 .

[18]  Y. Fujitani,et al.  Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats. , 2011, The Journal of toxicological sciences.

[19]  R. Burnett,et al.  Confounding and exposure measurement error in air pollution epidemiology , 2011, Air Quality, Atmosphere & Health.

[20]  Joshua M. Langberg,et al.  Effects of Stimulant Medication, Incentives, and Event Rate on Reaction Time Variability in Children With ADHD , 2011, Neuropsychopharmacology.

[21]  A. Peters,et al.  Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association , 2010, Circulation.

[22]  F. Cassee,et al.  Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain , 2010, Particle and Fibre Toxicology.

[23]  S. Jaeggi,et al.  The concurrent validity of the N-back task as a working memory measure , 2010, Memory.

[24]  L. Calderón-Garcidueñas,et al.  Air pollution: mechanisms of neuroinflammation and CNS disease , 2009, Trends in Neurosciences.

[25]  K Ikeda,et al.  Variations of formaldehyde and VOC levels during 3 years in new and older homes. , 2006, Indoor air.

[26]  J. E. Fischel,et al.  The impact of preschool inattention, hyperactivity, and impulsivity on social and academic development: a review. , 2005, Journal of child psychology and psychiatry, and allied disciplines.

[27]  F. Castellanos,et al.  Varieties of Attention-Deficit/Hyperactivity Disorder-Related Intra-Individual Variability , 2005, Biological Psychiatry.

[28]  Jocelyn Kaiser,et al.  Mounting Evidence Indicts Fine-Particle Pollution , 2005, Science.

[29]  Bruce D. McCandliss,et al.  Development of attentional networks in childhood , 2004, Neuropsychologia.

[30]  R. Canfield,et al.  Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter , 2003 .

[31]  R. Goodman,et al.  Psychometric properties of the strengths and difficulties questionnaire. , 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

[32]  C. Iadecola.  Neurogenic control of the cerebral microcirculation: is dopamine minding the store? , 1998, Nature Neuroscience.

[33]  J. C. Ballard.  Computerized assessment of sustained attention: a review of factors affecting vigilance performance. , 1996, Journal of clinical and experimental neuropsychology.

[34]  A. Baddeley.  Exploring the Central Executive , 1996 .

[35]  N. Lavie.  Perceptual load as a necessary condition for selective attention. , 1995, Journal of experimental psychology. Human perception and performance.

[36]  W. MacNee,et al.  Particulate air pollution and acute health effects , 1995, The Lancet.

[37]  D. Norman,et al.  Attention to Action: Willed and Automatic Control of Behavior Technical Report No. 8006. , 1980 .

[38]  M. Roizen,et al.  Public health importance of triggers of myocardial infarction: a comparative risk assessment , 2012 .

[39]  T. Sandström,et al.  Adverse cardiovascular effects of air pollution , 2009, Nature Clinical Practice Cardiovascular Medicine.

[40]  Michael J. Kofler,et al.  Quantifying ADHD classroom inattentiveness, its moderators, and variability: a meta-analytic review. , 2008, Journal of child psychology and psychiatry, and allied disciplines.

[41]  J. Kaiser.  Epidemiology. Mounting evidence indicts fine-particle pollution. , 2005, Science.

[42]  A. Peters,et al.  Exposure to traffic and the onset of myocardial infarction , 2005 .

[43]  Synnöve Carlson,et al.  Audiospatial and visuospatial working memory in 6-13 year old school children. , 2003, Learning & memory.