In search of innovative techniques to evaluate pharmaceutical R&D projects

Abstract This paper is a conceptual paper that examines a new integrative evaluation approach for pharmaceutical R&D projects. It describes recent changes in the health care economy and the underlying scientific and technological revolution that has markedly altered the business environment in which the pharmaceutical industry operates. Changes in cost and technology resulting from managed care organizations, marketing, generic drugs, new drug development risk, and scientific and technological evolution forced us to think of a new way to evaluate R&D projects in the early phase of the project. These changes have placed increased emphasis on the need for improvements in technology management methodologies. A real options approach, especially when combined with other project risk management processes, offers a significant improvement in project selection and review, and resource allocation decisions.

[1]  Y. Kwak,et al.  Assessing Project Management Maturity , 2000 .

[2]  Rita Gunther McGrath A Real Options Logic for Initiating Technology Positioning Investments , 1997 .

[3]  M. Hitt,et al.  The new competitive landscape , 1995 .

[4]  Ariane Reiss Investment in innovations and competition: an option pricing approach , 1998 .

[5]  E. Jarrett The Role of Risk in Business Decision-Making, or How To Stop Worrying and Love the Bombs , 2000 .

[6]  Adedeji Badiru,et al.  Comprehensive Project Management: Integrating Optimization Models, Management Principles, and Computers , 1994 .

[7]  Robert K. Perdue,et al.  Valuation of R and D Projects Using Options Pricing and Decision Analysis Models , 1999, Interfaces.

[8]  E. Pennings,et al.  R&D as an option on market introduction , 1998 .

[9]  T. Luehrman,et al.  Strategy as a portfolio of real options. , 1998, Harvard business review.

[10]  F. Black,et al.  The Pricing of Options and Corporate Liabilities , 1973, Journal of Political Economy.

[11]  N. A. Nichols Scientific management at Merck: An interview with CFO Judy Lewent , 1994 .

[12]  Alan R. Fusfeld,et al.  Resolving Uncertainty in R&D Portfolios , 2000 .

[13]  Paul S. Royer Risk Management: The Undiscovered Dimension of Project Management , 2000 .

[14]  Jeffrey L. Ringuest,et al.  Formulating Optimal R&D Portfolios , 2000 .

[15]  Steve Bone,et al.  Developing Effective Technology Strategies , 2000 .

[16]  T. Keelin,et al.  How SmithKline Beecham makes better resource-allocation decisions. , 1998, Harvard business review.

[17]  R. Cooper,et al.  New Problems, New Solutions: Making Portfolio Management More Effective , 2000 .

[18]  Ian C. MacMillan,et al.  Assessing Technology Projects Using Real Options Reasoning , 2000 .

[19]  Manfred Perlitz,et al.  Real options valuation: the new frontier in R&D project evaluation? , 1999 .

[20]  George S. Day,et al.  Avoiding the Pitfalls of Emerging Technologies , 2000 .

[21]  Hemantha S. B. Herath,et al.  ECONOMIC ANALYSIS OF R&D PROJECTS: AN OPTIONS APPROACH , 1999 .

[22]  W. David Sheasley,et al.  Taking an Options Approach to New Technology Development , 2000 .

[23]  A. Jägle,et al.  Shareholder Value, Real Options, and Innovation in Technology‐Intensive Companies , 1999 .

[24]  A. D. Henriksen,et al.  A practical R&D project-selection scoring tool , 1999 .

[25]  Stephen Ward Requirements for an Effective Project Risk Management Process , 1999 .

[26]  B Agnew,et al.  When Pharma Merges, R&D Is the Dowry , 2000, Science.

[27]  Diana I. Angelis,et al.  Capturing the Option Value of R&D , 2000 .