Genetic analysis of circadian clocks.

The goals of this review are twofold. The opening section introduces the tools and concepts of the genetic approach to understanding circadian rhythms. The following sections review the pertinent literature with an emphasis on those studies and approaches that appear most likely to lead to new answers to old questions concerning the mechanism(s) of circadian rhythmicity. This survey has been made somewhat simpler due the series of excellent reviews on clocks that have appeared over the past five years (35, 36, 38, 39, 42,63,64,65,66,67,68,84,96, 107, 1 18,153, 183, 184, 189). The length of this list reflects, in part, both a maturing of the genetics and molecular genetics of circadian clocks as a field, and an increasing interest and appreciation of the strengths of genetics in offering a different set of tools and a different way of thinking about the problems that circadian biologists have been considering for several decades.

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