Classification issues in malformations caused by abnormalities of cortical development.

Malformations caused by abnormalities of cortical development (MCDs) as a group are now widely recognized as a key cause of medically refractory epilepsies, often leading to a consideration of surgical treatment. A practical classification scheme including histopathologic, imaging, and, if possible, clinical-electrographic features of the various different types of MCDs, will be important to the delineation of surgical strategies and anticipation of medical and surgical prognoses. A proposal of such a scheme with emphasis on the focal cortical dysplasias is given in the hopes that it will reopen the debate on the best way to classify these disorders.

[1]  R K Fulbright,et al.  Cerebrospinal fluid cleft with cortical dimple: MR imaging marker for focal cortical dysgenesis. , 2000, Radiology.

[2]  H Staunton,et al.  Microdysgenesis in resected temporal neocortex , 1988, Neurology.

[3]  R. Goodman,et al.  Prospective magnetic resonance imaging identification of focal cortical dysplasia, including the non—balloon cell subtype , 1998, Annals of neurology.

[4]  S Lehéricy,et al.  Hippocampal developmental changes in patients with partial epilepsy: Magnetic resonance imaging and clinical aspects , 1998, Annals of neurology.

[5]  T Metens,et al.  Perisylvian dysgenesis. Clinical, EEG, MRI and glucose metabolism features in 10 patients. , 1998, Brain : a journal of neurology.

[6]  B. Bourgeois,et al.  MRI of focal cortical dysplasia , 1998, Neuroradiology.

[7]  Annette Karmiloff-Smith,et al.  Developmental disorders , 1998 .

[8]  P. Genton,et al.  Multilobar polymicrogyria, intractable drop attack seizures, and sleep-related electrical status epilepticus , 1998, Neurology.

[9]  T. Palmer,et al.  Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  Y. Ben-Ari,et al.  Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[11]  F. Andermann,et al.  Diffuse cortical dysplasia, or the 'double cortex' syndrome , 1991, Neurology.

[12]  G. Holmes,et al.  Consequences of Cortical Dysplasia During Development in Rats , 1999, Epilepsia.

[13]  P. Livrea,et al.  Metabolic Changes in Neuronal Migration Disorders: Evaluation by Combined MRI and Proton MR Spectroscopy , 1999, Epilepsia.

[14]  A. Ito,et al.  A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia , 1999, Human Genetics.

[15]  F Andermann,et al.  Cortical dysplasia , 1998, Neurology.

[16]  D. Spencer,et al.  Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors. , 1997, AJNR. American journal of neuroradiology.

[17]  S. Roper In utero irradiation of rats as a model of human cerebrocortical dysgenesis: a review , 1998, Epilepsy Research.

[18]  J J Kim,et al.  Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. , 1993, Archives of general psychiatry.

[19]  F. Andermann,et al.  STAGES AND PATTERNS OF CENTRIFUGAL ARREST OF DIFFUSE NEURONAL MIGRATION DISORDERS , 1993, Developmental medicine and child neurology.

[20]  D R Fish,et al.  Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. , 1995, Brain : a journal of neurology.

[21]  T. Morioka,et al.  Intrinsic epileptogenicity of focal cortical dysplasia as revealed by magnetoencephalography and electrocorticography , 1999, Epilepsy Research.

[22]  B. Swartz,et al.  Granule cell disorganization in the dentate gyrus: possible alterations of neuronal migration in human temporal lobe epilepsy. , 1992, Epilepsy research. Supplement.

[23]  I. Scheffer,et al.  Characterization of mutations in the gene doublecortin in patients with double cortex syndrome , 1999, Annals of neurology.

[24]  A. Barkovich,et al.  Schizencephaly: correlation of clinical findings with MR characteristics. , 1992, AJNR. American journal of neuroradiology.

[25]  C D Binnie,et al.  Surgical treatment of epilepsy due to cortical dysplasia: clinical and EEG findings. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[26]  D Mattia,et al.  Epileptiform discharges in the human dysplastic neocortex: In vitro physiology and pharmacology , 1999, Annals of neurology.

[27]  H. Lüders,et al.  Histopathological Correlates of Epileptogenicity as Expressed by Electrocorticographic Spiking and Seizure Frequency , 1998, Epilepsia.

[28]  H. Sarnat Disturbances of late neuronal migrations in the perinatal period. , 1987, American journal of diseases of children.

[29]  A. Benabid,et al.  Immunocytochemical investigation on dysplastic human tissue from epileptic patients , 1998, Epilepsy Research.

[30]  E R Laws,et al.  Dysembryoplastic neuroepithelial tumor : a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases , 1988 .

[31]  F Cendes,et al.  Diagnosis of subtle focal dysplastic lesions: Curvilinear reformatting from three‐dimensional magnetic resonance imaging , 1999, Annals of neurology.

[32]  R. Cardini,et al.  Familial schizencephaly associated with EMX2 mutation , 1997, Neurology.

[33]  Y. Ben-Ari,et al.  Cortical Malformations and Epilepsy: New Insights from Animal Models , 1999, Epilepsia.

[34]  A J Barkovich,et al.  Focal transmantle dysplasia: A specific malformation of cortical development , 1997, Neurology.

[35]  C. Lombroso,et al.  Can Early Postnatal Closed Head Injury Induce Cortical Dysplasia? , 2000, Epilepsia.

[36]  William B Dobyns,et al.  Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia , 1998, Neuron.

[37]  N. Barbaro,et al.  Life-threatening focal status epilepticus due to occult cortical dysplasia. , 1993, Archives of neurology.

[38]  F. Andermann,et al.  Operative Strategies for Patients with Cortical Dysplastic Lesions and Intractable Epilepsy , 1994, Epilepsia.

[39]  W Paulus,et al.  Temporal lobe microdysgenesis in epilepsy versus control brains. , 1999, Journal of neuropathology and experimental neurology.

[40]  M. Akil,et al.  Cytoarchitecture of the entorhinal cortex in schizophrenia. , 1997, The American journal of psychiatry.

[41]  F. Andermann,et al.  Neuronal Migration Disorders: A Contribution of Modern Neuroimaging to the Etiologic Diagnosis of Epilepsy , 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[42]  N. Geschwind,et al.  Developmental dyslexia: Four consecutive patients with cortical anomalies , 1985, Annals of neurology.

[43]  M. Calcagnotto,et al.  Neuropatologia das epilepsias de difícil controle: estudo de 300 casos consecutivos , 1999 .

[44]  F Andermann,et al.  Focal neuronal migration disorders and intractable partial epilepsy: Results of surgical treatment , 1991, Annals of neurology.

[45]  D. Norman,et al.  MR of neuronal migration anomalies. , 1987, AJR. American journal of roentgenology.

[46]  I. Tuxhorn,et al.  Paediatric Epilepsy Syndromes and their Surgical Treatment , 1999, Seizure.

[47]  F Andermann,et al.  Focal neuronal migration disorders and intractable partial epilepsy: A study of 30 patients , 1991, Annals of neurology.

[48]  A. Palmini,et al.  Disorders of cortical development. , 2000, Current opinion in neurology.

[49]  Vincent de Paul,et al.  HEMIMEGALENCEPHALY: A CLINICOPATHOLOGICAL STUDY OF FOUR CASES , 1988, Neuropathology and applied neurobiology.

[50]  D. Arnold,et al.  Neuronal metabolic dysfunction in patients with cortical developmental malformations , 1998, Neurology.

[51]  H. Otsubo,et al.  Early forms of microtubule-associated protein are strongly expressed in cortical dysplasia , 1998, Acta Neuropathologica.

[52]  D. Janz,et al.  The Significance of Microdysgenesia in Primary Generalized Epilepsy: An Answer to the Considerations of Lyon and Gastaut , 1985, Epilepsia.

[53]  F. Andermann,et al.  Prenatal Events and Genetic Factors in Epileptic Patients with Neuronal Migration Disorders , 1994, Epilepsia.

[54]  H. Vinters,et al.  Neuropathologic findings in surgically treated hemimegalencephaly: immunohistochemical, morphometric, and ultrastructural study , 2004, Acta Neuropathologica.

[55]  Frederick Andermann,et al.  Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results , 1995, Annals of neurology.

[56]  P Evrard,et al.  A classification scheme for malformations of cortical development. , 1996, Neuropediatrics.

[57]  L F Quesney,et al.  Usefulness of focal rhythmic discharges on scalp EEG of patients with focal cortical dysplasia and intractable epilepsy. , 1996, Electroencephalography and clinical neurophysiology.

[58]  M. Luca,et al.  Altered connections between neocortical and heterotopic areas in methylazoxymethanol-treated rat , 1998, Epilepsy Research.

[59]  M A Falconer,et al.  Focal dysplasia of the cerebral cortex in epilepsy , 1971, Journal of neurology, neurosurgery, and psychiatry.

[60]  R. Guerrini Dysplasias of cerebral cortex and epilepsy , 1996 .

[61]  S. Potkin,et al.  New morphological and neuropathological findings in schizophrenia: a neurodevelopmental perspective. , 1995, Clinical neuroscience.

[62]  Eric Courchesne,et al.  Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism , 1997, Current Opinion in Neurobiology.

[63]  T. Kemper,et al.  Hippocampus in autism: a Golgi analysis , 1995, Acta Neuropathologica.

[64]  Rita Garbelli,et al.  Taylor's Cortical Dysplasia: A Confocal and Ultrastructural Immunohistochemical Study , 1999, Brain pathology.

[65]  N. Fejerman,et al.  A Particular Type of Epilepsy in Children with Congenital Hemiparesis Associated with Unilateral Polymicrogyria , 1999, Epilepsia.

[66]  T. Babb,et al.  Epileptogenicity Correlated with Increased N‐Methyl‐d‐Aspartate Receptor Subunit NR2A/B in Human Focal Cortical Dysplasia , 2000, Epilepsia.

[67]  R. Kuzniecky,et al.  Cortical dysplasia in temporal lobe epilepsy: Magnetic resonance imaging correlations , 1991, Annals of neurology.

[68]  P. Mischel,et al.  Cerebral Cortical Dysplasia Associated with Pediatric Epilepsy. Review of Neuropathologic Features and Proposal for a Grading System , 1995, Journal of neuropathology and experimental neurology.

[69]  C. Adamsbaum,et al.  Focal cortical dysplasia and hemimegalencephaly: histological and neuroimaging correlations , 1998, Pediatric Radiology.

[70]  S Lehéricy,et al.  Developmental abnormalities of the medial temporal lobe in patients with temporal lobe epilepsy. , 1995, AJNR. American journal of neuroradiology.

[71]  D. Keene,et al.  Cortical Microdysplasia and Surgical Outcome in Refractory Epilepsy of Childhood , 1998, Pediatric Neurosurgery.

[72]  M. Avoli,et al.  The significance of electrocorticographic findings in focal cortical dysplasia: a review of their clinical, electrophysiological and neurochemical characteristics. , 1998, Electroencephalography and clinical neurophysiology. Supplement.

[73]  M. Pineda,et al.  Abnormal local-circuit neurons in epilepsia partialis continua associated with focal cortical dysplasia , 2004, Acta Neuropathologica.