Epigenomic Consequences of Coding and Noncoding Driver Mutations.

[1]  B. Garcia,et al.  Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape , 2016, Science.

[2]  J. Parker,et al.  An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27 trimethylation throughout the genome , 2016, Nature Medicine.

[3]  Joaquim Bellmunt,et al.  Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles , 2016, Nature Medicine.

[4]  Anushi Shah,et al.  Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes , 2016, Nature.

[5]  S. Horswell,et al.  Mutation of cancer driver MLL2 results in transcription stress and genome instability , 2016, Genes & development.

[6]  Steven J. M. Jones,et al.  Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma , 2016, Cell.

[7]  Roland Eils,et al.  Active medulloblastoma enhancers reveal subgroup-specific cellular origins , 2016, Nature.

[8]  Steven J. M. Jones,et al.  Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. , 2016, The New England journal of medicine.

[9]  Shawn M. Gillespie,et al.  An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma , 2016, Nature Genetics.

[10]  R. Elkon,et al.  Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9 , 2016, Nature Biotechnology.

[11]  Marcin Imielinski,et al.  Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers , 2015, Nature Genetics.

[12]  J. Dick,et al.  MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. , 2015, Cancer cell.

[13]  Shawn M. Gillespie,et al.  Insulator dysfunction and oncogene activation in IDH mutant gliomas , 2015, Nature.

[14]  Jean-Christophe Aude,et al.  Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells , 2015, Nature.

[15]  L. Chin,et al.  Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. , 2015, The Journal of clinical investigation.

[16]  Thomas P. Howard,et al.  SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 , 2015, Nature Medicine.

[17]  Daniel S. Day,et al.  Activation of proto-oncogenes by disruption of chromosome neighborhoods , 2015, Science.

[18]  Webster K. Cavenee,et al.  EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. , 2015, Molecular cell.

[19]  Radhakrishnan Sabarinathan,et al.  Nucleotide excision repair is impaired by binding of transcription factors to DNA , 2015, Nature.

[20]  Timothy E. Reddy,et al.  Highly Specific Epigenome Editing by CRISPR/Cas9 Repressors for Silencing of Distal Regulatory Elements , 2015, Nature Methods.

[21]  Swe Swe Myint,et al.  Genomic landscapes of breast fibroepithelial tumors , 2015, Nature Genetics.

[22]  D. Weitz,et al.  Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state , 2015, Nature Biotechnology.

[23]  David M. Woods,et al.  HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade , 2015, Cancer Immunology Research.

[24]  Cheryl H. Arrowsmith,et al.  Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth , 2015, Nature.

[25]  Shawn M. Gillespie,et al.  Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma. , 2015, Cancer discovery.

[26]  A. Børresen-Dale,et al.  Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells , 2015, Genes & development.

[27]  Niko Välimäki,et al.  CTCF/cohesin-binding sites are frequently mutated in cancer , 2015, Nature Genetics.

[28]  M. Snyder,et al.  Recurrent Somatic Mutations in Regulatory Regions of Human Cancer Genomes , 2015, Nature Genetics.

[29]  Philip A. Ewels,et al.  Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C , 2015, Nature Genetics.

[30]  Christopher M. Vockley,et al.  Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers , 2015, Nature Biotechnology.

[31]  S. Prabhakar,et al.  Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms , 2015, Nature Methods.

[32]  Margaret A. Goodell,et al.  DNMT3A in haematological malignancies , 2015, Nature Reviews Cancer.

[33]  Dylan J. Taatjes,et al.  The Mediator complex: a central integrator of transcription , 2015, Nature Reviews Molecular Cell Biology.

[34]  Benjamin G. Bitler,et al.  Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers , 2015, Nature Medicine.

[35]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[36]  Paz Polak,et al.  Cell-of-origin chromatin organization shapes the mutational landscape of cancer , 2015, Nature.

[37]  Lukas Burger,et al.  Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation , 2015, Nature.

[38]  Stephen C. J. Parker,et al.  Stretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells , 2014, Nature.

[39]  R. Wilson,et al.  Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin , 2014 .

[40]  R. Klose,et al.  Understanding the relationship between DNA methylation and histone lysine methylation , 2014, Biochimica et biophysica acta.

[41]  Shawn M. Gillespie,et al.  EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. , 2014, Cancer cell.

[42]  R. Young,et al.  An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element , 2014, Science.

[43]  Pengyuan Yang,et al.  BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing. , 2014, Molecular cell.

[44]  C. Roberts,et al.  Vulnerabilities of mutant SWI/SNF complexes in cancer. , 2014, Cancer cell.

[45]  R. Johnstone,et al.  Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders , 2015, Nature Reviews Drug Discovery.

[46]  Swe Swe Myint,et al.  Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma , 2014, Nature Genetics.

[47]  Bin Tean Teh,et al.  Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements , 2014, Nature Communications.

[48]  Steven J. M. Jones,et al.  Comprehensive molecular profiling of lung adenocarcinoma , 2014, Nature.

[49]  Gary D Bader,et al.  Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma , 2014, Nature.

[50]  A. Losada,et al.  Cohesin in cancer: chromosome segregation and beyond , 2014, Nature Reviews Cancer.

[51]  I. Shmulevich,et al.  CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. , 2014, Cell reports.

[52]  Christopher A. Miller,et al.  The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. , 2014, Cancer cell.

[53]  Christopher M. Weber,et al.  Histone variants: dynamic punctuation in transcription , 2014, Genes & development.

[54]  P. Black Frequent truncating mutations of STAG2 in bladder cancer. , 2014, Urology.

[55]  S. Armstrong,et al.  Mutations in epigenetic regulators including SETD2 are gained during relapse in pediatric acute lymphoblastic leukemia , 2014, Nature Communications.

[56]  Min Gyu Lee,et al.  UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. , 2014, Cancer research.

[57]  G. Almouzni,et al.  Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX. , 2014, Molecular cell.

[58]  S. Mi,et al.  Identification of functional cooperative mutations of SETD2 in human acute leukemia , 2014, Nature Genetics.

[59]  P. A. Futreal,et al.  Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing , 2014, Nature Genetics.

[60]  Steven J. M. Jones,et al.  Comprehensive molecular characterization of urothelial bladder carcinoma , 2014, Nature.

[61]  Martin J. Aryee,et al.  Epigenome-wide association studies without the need for cell-type composition , 2014, Nature Methods.

[62]  M. Gobbi,et al.  Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment , 2014, Nature Genetics.

[63]  M. Lupien,et al.  Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits , 2014, Genome research.

[64]  Mark I. McCarthy,et al.  Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants , 2013, Nature Genetics.

[65]  M. Calaminici,et al.  Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma , 2013, Nature Genetics.

[66]  J. Stamatoyannopoulos,et al.  Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair , 2013, Nature Biotechnology.

[67]  Weiqun Peng,et al.  H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation , 2013, eLife.

[68]  C. Taylor,et al.  Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes , 2013, Human molecular genetics.

[69]  David T. W. Jones,et al.  Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. , 2013, Cancer cell.

[70]  R. Young,et al.  Super-Enhancers in the Control of Cell Identity and Disease , 2013, Cell.

[71]  L. Staudt,et al.  EZH2 mutations are frequent and represent an early event in follicular lymphoma. , 2013, Blood.

[72]  M. Stratton,et al.  Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone , 2013, Nature Genetics.

[73]  Kristian Helin,et al.  Chromatin proteins and modifications as drug targets , 2013, Nature.

[74]  Yan Li,et al.  A high-resolution map of three-dimensional chromatin interactome in human cells , 2013, Nature.

[75]  Benjamin J. Raphael,et al.  Mutational landscape and significance across 12 major cancer types , 2013, Nature.

[76]  Stephen C. J. Parker,et al.  Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants , 2013, Proceedings of the National Academy of Sciences.

[77]  C. Plass,et al.  Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer , 2013, Nature Reviews Genetics.

[78]  Howard Y. Chang,et al.  Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position , 2013, Nature Methods.

[79]  A. Shilatifard,et al.  The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers , 2013, Molecular and Cellular Biology.

[80]  J. Stender,et al.  Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. , 2013, Molecular cell.

[81]  T. Holland-Letz,et al.  ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis , 2013, Acta Neuropathologica.

[82]  Martha L. Bulyk,et al.  Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos , 2013, Nature Methods.

[83]  Laurence Amar,et al.  SDH mutations establish a hypermethylator phenotype in paraganglioma. , 2013, Cancer cell.

[84]  Peter J. Park,et al.  Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters , 2013, Proceedings of the National Academy of Sciences.

[85]  Benjamin J. Raphael,et al.  Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. , 2013, The New England journal of medicine.

[86]  B. Garcia,et al.  Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma , 2013, Science.

[87]  Fang Wang,et al.  An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells , 2013, Science.

[88]  Fang Wang,et al.  Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation , 2013, Science.

[89]  A. Ashworth,et al.  Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN. , 2013, Cancer discovery.

[90]  Steven J. M. Jones,et al.  Integrated genomic characterization of endometrial carcinoma , 2013, Nature.

[91]  Wei Yang,et al.  The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα , 2013, Cell.

[92]  P. Meltzer,et al.  Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. , 2013, Cancer discovery.

[93]  David A. Orlando,et al.  Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.

[94]  David A. Orlando,et al.  Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers , 2013, Cell.

[95]  K. Kinzler,et al.  Cancer Genome Landscapes , 2013, Science.

[96]  Łukasz M. Boryń,et al.  Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq , 2013, Science.

[97]  D. Schadendorf,et al.  TERT Promoter Mutations in Familial and Sporadic Melanoma , 2013, Science.

[98]  Lynda Chin,et al.  Highly Recurrent TERT Promoter Mutations in Human Melanoma , 2013, Science.

[99]  David T. W. Jones,et al.  Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas , 2013, Acta Neuropathologica.

[100]  N. Yoo,et al.  Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers , 2013, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[101]  Gangning Liang,et al.  Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules , 2012, Genome research.

[102]  Masao Nagasaki,et al.  Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms , 2012, Nature Genetics.

[103]  Yan Liu,et al.  EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations , 2012, Nature.

[104]  Data production leads,et al.  An integrated encyclopedia of DNA elements in the human genome , 2012 .

[105]  K. Cibulskis,et al.  Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer , 2012, Nature Genetics.

[106]  Xiao-Jun Feng,et al.  Expression and prognostic significance of centromere protein A in human lung adenocarcinoma. , 2012, Lung cancer.

[107]  B. Schuster-Böckler,et al.  Chromatin organization is a major influence on regional mutation rates in human cancer cells , 2012, Nature.

[108]  A. Sivachenko,et al.  A Landscape of Driver Mutations in Melanoma , 2012, Cell.

[109]  Hui Yang,et al.  Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. , 2012, Genes & development.

[110]  Keith A. Boroevich,et al.  Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators , 2012, Nature Genetics.

[111]  Jason H. Moore,et al.  Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer , 2012, Science.

[112]  C. Bountra,et al.  Epigenetic protein families: a new frontier for drug discovery , 2012, Nature Reviews Drug Discovery.

[113]  Jesse R. Dixon,et al.  Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin Interactions , 2012, Nature.

[114]  Bin Tean Teh,et al.  Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes , 2012, Nature Genetics.

[115]  Z. Yakhini,et al.  Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters , 2012, Nature Biotechnology.

[116]  S. Berger,et al.  IDH mutation impairs histone demethylation and results in a block to cell differentiation , 2012, Nature.

[117]  A. Viale,et al.  IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype , 2012, Nature.

[118]  I. Tomlinson,et al.  Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression , 2012, Nature Genetics.

[119]  Yong Jiang,et al.  Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) , 2012, Proceedings of the National Academy of Sciences.

[120]  J. Issa,et al.  Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia , 2012, Epigenetics.

[121]  David T. W. Jones,et al.  Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma , 2012, Nature.

[122]  P. Giresi,et al.  Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA , 2012, Nature Protocols.

[123]  B. Pugh,et al.  Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution , 2011, Cell.

[124]  J. Berg,et al.  Dnmt3a is essential for hematopoietic stem cell differentiation , 2011, Nature Genetics.

[125]  M. J. Mendiburo,et al.  Drosophila CENH3 Is Sufficient for Centromere Formation , 2011, Science.

[126]  L. Aaltonen,et al.  MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas , 2011, Science.

[127]  Huanming Yang,et al.  Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder , 2011, Nature Genetics.

[128]  S. Dimitrov,et al.  Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin. , 2011, Genome research.

[129]  Yang Wang,et al.  Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA , 2011, Science.

[130]  Steven J. M. Jones,et al.  Frequent mutation of histone modifying genes in non-Hodgkin lymphoma , 2011, Nature.

[131]  B. E. Black,et al.  HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore , 2011, The Journal of cell biology.

[132]  R. McLendon,et al.  Altered Telomeres in Tumors with ATRX and DAXX Mutations , 2011, Science.

[133]  Lars Bullinger,et al.  MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. , 2011, Cancer cell.

[134]  Yonghong Xiao,et al.  Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. , 2011, Cancer cell.

[135]  Song Tan,et al.  Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms , 2011, Nucleic acids research.

[136]  C. Roberts,et al.  SWI/SNF nucleosome remodellers and cancer , 2011, Nature Reviews Cancer.

[137]  Chee Seng Chan,et al.  CTCF-Mediated Functional Chromatin Interactome in Pluripotent Cells , 2011, Nature Genetics.

[138]  Matthew D. Young,et al.  ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity , 2011, Nucleic acids research.

[139]  R. Klose,et al.  The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases , 2011, EMBO reports.

[140]  Yong-mei Zhu,et al.  Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia , 2011, Nature Genetics.

[141]  Li Ding,et al.  Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes , 2011, Leukemia.

[142]  Kenneth H. Buetow,et al.  CREBBP mutations in relapsed acute lymphoblastic leukaemia , 2011, Nature.

[143]  Michael A. Choti,et al.  DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors , 2011, Science.

[144]  Ryan D. Morin,et al.  Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. , 2011, Blood.

[145]  Zev A. Binder,et al.  The Genetic Landscape of the Childhood Cancer Medulloblastoma , 2011, Science.

[146]  Bin Wang,et al.  Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. , 2011, Cancer cell.

[147]  J. Licht,et al.  Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. , 2010, Cancer cell.

[148]  L. Aravind,et al.  Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 , 2010, Nature.

[149]  P. A. Futreal,et al.  Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma , 2010, Nature.

[150]  R. Copeland,et al.  Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas , 2010, Proceedings of the National Academy of Sciences.

[151]  Richard A. Moore,et al.  ARID1A mutations in endometriosis-associated ovarian carcinomas. , 2010, The New England journal of medicine.

[152]  Tian-Li Wang,et al.  Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma , 2010, Science.

[153]  J. Reyes,et al.  BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivo , 2010, EMBO reports.

[154]  William B. Smith,et al.  Selective inhibition of BET bromodomains , 2010, Nature.

[155]  Andrew J. Bannister,et al.  Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3 , 2010, Nature Cell Biology.

[156]  H. Drexler,et al.  Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders , 2010, Nature Genetics.

[157]  David A. Orlando,et al.  Mediator and Cohesin Connect Gene Expression and Chromatin Architecture , 2010, Nature.

[158]  C. Allis,et al.  Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres , 2010, Proceedings of the National Academy of Sciences.

[159]  Albert Jeltsch,et al.  The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation* , 2010, The Journal of Biological Chemistry.

[160]  M. Caligiuri,et al.  IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[161]  Jian-Bing Fan,et al.  Genome‐wide DNA methylation profiling , 2010, Wiley interdisciplinary reviews. Systems biology and medicine.

[162]  Laura Lentini,et al.  CENPA overexpression promotes genome instability in pRb-depleted human cells , 2009, Molecular Cancer.

[163]  L. Liau,et al.  Cancer-associated IDH1 mutations produce 2-hydroxyglutarate , 2009, Nature.

[164]  R. McLendon,et al.  IDH1 and IDH2 mutations in gliomas. , 2009, The New England journal of medicine.

[165]  Lee E. Edsall,et al.  Human DNA methylomes at base resolution show widespread epigenomic differences , 2009, Nature.

[166]  Gurpreet W. Tang,et al.  Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes , 2009, Nature.

[167]  I. Amit,et al.  Comprehensive mapping of long range interactions reveals folding principles of the human genome , 2011 .

[168]  P. Park ChIP–seq: advantages and challenges of a maturing technology , 2009, Nature Reviews Genetics.

[169]  K. Gunderson,et al.  Genome-wide DNA methylation profiling using Infinium® assay. , 2009, Epigenomics.

[170]  E. Liu,et al.  An Oestrogen Receptor α-bound Human Chromatin Interactome , 2009, Nature.

[171]  Ken Chen,et al.  Recurring mutations found by sequencing an acute myeloid leukemia genome. , 2009, The New England journal of medicine.

[172]  R. Levine,et al.  Mutation in TET2 in myeloid cancers. , 2009, The New England journal of medicine.

[173]  H. Cedar,et al.  Linking DNA methylation and histone modification: patterns and paradigms , 2009, Nature Reviews Genetics.

[174]  Bin Tean Teh,et al.  Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer , 2009, Nature Genetics.

[175]  Angela Tam,et al.  Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells. , 2008, Genome research.

[176]  Jun Yokota,et al.  Frequent BRG1/SMARCA4–inactivating mutations in human lung cancer cell lines , 2008, Human mutation.

[177]  H. Hibshoosh,et al.  BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. , 2008, Cancer research.

[178]  Dustin E. Schones,et al.  Dynamic Regulation of Nucleosome Positioning in the Human Genome , 2008, Cell.

[179]  Z. Weng,et al.  High-Resolution Mapping and Characterization of Open Chromatin across the Genome , 2008, Cell.

[180]  A. Sparks,et al.  The Genomic Landscapes of Human Breast and Colorectal Cancers , 2007, Science.

[181]  Min Gyu Lee,et al.  Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination , 2007, Science.

[182]  I. Issaeva,et al.  UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development , 2007, Nature.

[183]  Howard Y. Chang,et al.  A histone H3 lysine 27 demethylase regulates animal posterior development , 2007, Nature.

[184]  M. Fraga,et al.  The Polycomb group protein EZH2 directly controls DNA methylation , 2007, Nature.

[185]  F. Baas,et al.  Germline mutation of INI1/SMARCB1 in familial schwannomatosis. , 2007, American journal of human genetics.

[186]  Nathaniel D. Heintzman,et al.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome , 2007, Nature Genetics.

[187]  C. Croce,et al.  Knockdown of ALR (MLL2) Reveals ALR Target Genes and Leads to Alterations in Cell Adhesion and Growth , 2006, Molecular and Cellular Biology.

[188]  K. Sandhu,et al.  Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions , 2006, Nature Genetics.

[189]  G. Parmigiani,et al.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers , 2006, Science.

[190]  A. Riggs,et al.  The Histone Methyltransferase SETDB1 and the DNA Methyltransferase DNMT3A Interact Directly and Localize to Promoters Silenced in Cancer Cells* , 2006, Journal of Biological Chemistry.

[191]  M. Pazin,et al.  Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions , 2006, Science.

[192]  S. Henikoff,et al.  Genome-scale profiling of histone H3.3 replacement patterns , 2005, Nature Genetics.

[193]  K. Robertson DNA methylation and human disease , 2005, Nature Reviews Genetics.

[194]  W. Lam,et al.  Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells , 2005, Nature Genetics.

[195]  Silvana Pilotti,et al.  SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. , 2005, Cancer research.

[196]  Eric S. Lander,et al.  Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse , 2005, Cell.

[197]  C. Peterson,et al.  Histones and histone modifications , 2004, Current Biology.

[198]  G. Almouzni,et al.  Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis , 2004, Cell.

[199]  R. Penzel,et al.  CTCF Gene Mutations in Invasive Ductal Breast Cancer , 2003, Breast Cancer Research and Treatment.

[200]  En Li,et al.  Suv 39 h-Mediated Histone H 3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin , 2003 .

[201]  T. Tomonaga,et al.  Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. , 2003, Cancer research.

[202]  T. Kouzarides,et al.  The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. , 2003, Nucleic acids research.

[203]  R. Salunga,et al.  Gene expression profiles of human breast cancer progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[204]  S. Dhanasekaran,et al.  The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.

[205]  J. P. Jackson,et al.  Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase , 2002, Nature.

[206]  J. Dekker,et al.  Capturing Chromosome Conformation , 2002, Science.

[207]  E. Selker,et al.  A histone H3 methyltransferase controls DNA methylation in Neurospora crassa , 2001, Nature.

[208]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[209]  C. Roberts,et al.  Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[210]  J. Jurka,et al.  Microsatellites in different eukaryotic genomes: survey and analysis. , 2000, Genome research.

[211]  Carlos Caldas,et al.  Mutations truncating the EP300 acetylase in human cancers , 2000, Nature Genetics.

[212]  Olivier Delattre,et al.  Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer , 1998, Nature.

[213]  C. Wills,et al.  Abundant microsatellite polymorphism in Saccharomyces cerevisiae, and the different distributions of microsatellites in eight prokaryotes and S. cerevisiae, result from strong mutation pressures and a variety of selective forces. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[214]  G. Schroth,et al.  Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA. , 1993, The Journal of biological chemistry.

[215]  H. Alder,et al.  The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene , 1992, Cell.

[216]  Michael L. Cleary,et al.  Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias , 1992, Cell.

[217]  G. Evans,et al.  A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias , 1992, Nature Genetics.

[218]  L. Kedes,et al.  Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family. , 1987, Nucleic acids research.

[219]  L. Kedes,et al.  Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[220]  O. Blau DNMT3A mutations in acute myeloid leukemia , 2016 .

[221]  L. Pasqualucci Diffuse Large B-Cell Lymphoma , 2013 .

[222]  J. Uhm IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype , 2012 .

[223]  S. Daignault,et al.  TET2 and DNMT3A Mutations in Human T-Cell Lymphoma , 2012 .

[224]  C. Galambos Small Cell Undifferentiated Variant of Hepatoblastoma: Adverse Clinical and Molecular Features Similar to Rhabdoid Tumors , 2010 .

[225]  M. Mann,et al.  A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements. , 2009, Genome research.

[226]  J. Uhm An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2009 .

[227]  A. Bird DNA methylation patterns and epigenetic memory. , 2002, Genes & development.

[228]  D. Metzgar,et al.  Selection against frameshift mutations limits microsatellite expansion in coding DNA. , 2000, Genome research.