Immunology research: challenges and opportunities in a time of budgetary constraint

There have been enormous advances in the field of immunology over the past 3 decades, and those advances have had a positive effect on many subspecialties of medicine. Opportunities for even more notable advances remain. However, present and projected budget constraints for the National Institutes of Health have created formidable challenges. This commentary addresses the opportunities and challenges for the field of immunology during a period of restricted budgets.

[1]  C. Janeway.  Approaching the asymptote? Evolution and revolution in immunology. , 1989, Cold Spring Harbor symposia on quantitative biology.

[2]  S. Akira,et al.  Mechanism of pathogen‐specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection , 2006, European journal of immunology.

[3]  A. Rudensky,et al.  A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 , 2005, Nature Immunology.

[4]  Mark S. Anderson,et al.  The cellular mechanism of Aire control of T cell tolerance. , 2005, Immunity.

[5]  C. Milstein,et al.  A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody , 1979, European journal of immunology.

[6]  G. DeFriese,et al.  The New York Times , 2020, Publishing for Libraries.

[7]  Zhengfan Jiang,et al.  Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. , 2006, Annual review of immunology.

[8]  M. Cancro,et al.  BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells. , 2006, Seminars in immunology.

[9]  J. Lindenmann,et al.  Virus interference. I. The interferon , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[10]  Ruslan Medzhitov,et al.  Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis , 2004, Cell.

[11]  Richard A Flavell,et al.  Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[12]  C. Coban,et al.  Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells , 2006, Nature Immunology.

[13]  J. Tschopp,et al.  Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. , 2006, Molecular cell.

[14]  T. Fujita.  Sensing Viral RNA Amid Your Own , 2006, Science.

[15]  L. Lefrançois,et al.  Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo. , 2006, Annual review of immunology.

[16]  S. Porcelli,et al.  Recognition of a lipid antigen by GDI-restricted αβ+ T cells , 1994, Nature.

[17]  E. B. Lindblad.  Aluminium adjuvants--in retrospect and prospect. , 2004, Vaccine.

[18]  Gunther Hartmann,et al.  5'-Triphosphate RNA Is the Ligand for RIG-I , 2006, Science.

[19]  A. Lanzavecchia,et al.  Toll‐like receptor stimulation as a third signal required for activation of human naive B cells , 2006, European journal of immunology.

[20]  C. Janeway.  Immunobiology: The Immune System in Health and Disease , 1996 .

[21]  D. Tscharke,et al.  Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy. , 2006, The Journal of general virology.

[22]  D. Dudley,et al.  The immune system in health and disease. , 1992, Bailliere's clinical obstetrics and gynaecology.

[23]  M. Pop,et al.  Metagenomic Analysis of the Human Distal Gut Microbiome , 2006, Science.

[24]  Bali Pulendran,et al.  Translating Innate Immunity into Immunological Memory: Implications for Vaccine Development , 2006, Cell.

[25]  A. Pichlmair,et al.  RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates , 2006, Science.

[26]  Fauci As.  Biomedical research in an era of unlimited aspirations and limited resources. , 1996 .

[27]  S. Mazmanian,et al.  An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System , 2005, Cell.