Protein turnover in the failing heart: an ever‐changing landscape

1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 2Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, MI, USA; 3Duke Clinical Research Institute, Durham, NC, USA; 4Division of Cardiology, Duke University Medical Center, Durham, NC, USA; and 5Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

[1]  L. Ji.  Faculty Opinions recommendation of Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[2]  H. Granzier,et al.  Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction , 2016, Circulation.

[3]  K. Otsu,et al.  Receptor-mediated mitophagy. , 2016, Journal of molecular and cellular cardiology.

[4]  Sanjiv J. Shah,et al.  Developing New Treatments for Heart Failure: Focus on the Heart , 2016, Circulation. Heart failure.

[5]  R. Garten,et al.  Evidence of microvascular dysfunction in heart failure with preserved ejection fraction , 2015, Heart.

[6]  Andrew J. Sauer,et al.  "Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection Fraction. , 2015, JACC. Heart failure.

[7]  S. Tyagi,et al.  Resuscitation of a dead cardiomyocyte , 2015, Heart Failure Reviews.

[8]  K. Otsu,et al.  Degradation systems in heart failure. , 2015, Journal of molecular and cellular cardiology.

[9]  M. Gheorghiade,et al.  Molecular and Cellular Basis of Viable Dysfunctional Myocardium , 2014, Circulation. Heart failure.

[10]  B. Udd,et al.  Gene Expression Profiling in Tibial Muscular Dystrophy Reveals Unfolded Protein Response and Altered Autophagy , 2014, PloS one.

[11]  Y. Ohsumi.  Historical landmarks of autophagy research , 2013, Cell Research.

[12]  W. Paulus,et al.  A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. , 2013, Journal of the American College of Cardiology.

[13]  A. Ciechanover.  Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. , 2013, Bioorganic & medicinal chemistry.

[14]  M. Gheorghiade,et al.  Mitochondria as a therapeutic target in heart failure. , 2013, Journal of the American College of Cardiology.

[15]  Yugang Dong,et al.  Proteasome inhibition attenuates heart failure during the late stages of pressure overload through alterations in collagen expression. , 2013, Biochemical pharmacology.

[16]  W. Paulus,et al.  Molecular and Cellular Basis for Diastolic Dysfunction , 2012, Current Heart Failure Reports.

[17]  Yugang Dong,et al.  MG132 treatment attenuates cardiac remodeling and dysfunction following aortic banding in rats via the NF-κB/TGFβ1 pathway. , 2011, Biochemical Pharmacology.

[18]  M. Muckenthaler,et al.  Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. , 2011, European heart journal.

[19]  W. Paulus,et al.  Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. , 2011, European heart journal.

[20]  K. Lindsten,et al.  Stressing the ubiquitin-proteasome system. , 2010, Cardiovascular research.

[21]  G. Fonarow,et al.  Micronutrient deficiencies an unmet need in heart failure. , 2009, Journal of the American College of Cardiology.

[22]  M. Gheorghiade,et al.  More than bricks and mortar: comments on protein and amino acid metabolism in the heart. , 2008, The American journal of cardiology.

[23]  S. Powell.  The ubiquitin-proteasome system in cardiac physiology and pathology. , 2006, American journal of physiology. Heart and circulatory physiology.

[24]  P. Razeghi,et al.  Cardiac remodeling: UPS lost in transit. , 2005, Circulation research.

[25]  D. Wolf,et al.  Endoplasmic reticulum-associated protein degradation--one model fits all? , 2004, Biochimica et biophysica acta.

[26]  J. Schaper,et al.  Myocytes Die by Multiple Mechanisms in Failing Human Hearts , 2003, Circulation research.

[27]  T. Levine,et al.  Abnormalities of contractile structures in viable myocytes of the failing heart. , 1994, International journal of cardiology.

[28]  M. Rath,et al.  Myocardial energetics and the role of micronutrients in heart failure: a critical review. , 2016, American journal of cardiovascular disease.

[29]  R. El-SherifNLazzara.  Negative Diastolic Pressure in the Intact Canine Right Ventricle , 1981 .