Clastogenicity of furans found in food.

Cultured Chinese hamster ovary (CHO) cells were exposed for 3 h to furan and 6 furan derivatives (furfural, furfuryl alcohol, 5-methyl furfural, 2-methyl furan, 2,5-dimethyl furan and 2-furyl methyl ketone). Each of the 6 furan derivatives induced a relatively high frequency of chromatid breaks and chromatid exchanges in the absence of a liver microsomal activation preparation. The response of the furans to the addition of an S9 mixture differed. The clastogenic activities of 5-methyl furfural, 2-furyl methyl ketone, furfural and furfuryl alcohol were increased, whereas that of 2-methyl furan and 2,5-dimethyl furan were significantly decreased. Furan itself showed a clastogenic activity only in the presence of an S9 mixture.

[1]  J. Weisburger,et al.  Formation of mutagens in cooked foods. II. Foods with high starch content. , 1980, Cancer letters.

[2]  W. Powrie,et al.  Mutagenic activity of pyrazine derivatives: a comparative study with Salmonella typhimurium, Saccharomyces cerevisiae and Chinese hamster ovary cells. , 1980, Food and cosmetics toxicology.

[3]  M. Lo,et al.  Polycyclic aromatic hydrocarbons (polynuclears) in foods. , 1978, Residue reviews.

[4]  P. S. Dietrich,et al.  Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test: activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources. , 1979, Mutation research.

[5]  J. Gray,et al.  N-Nitrosamides and their precursors in food systems. 1. Formation of N-substituted amides. , 1980, Journal of agricultural and food chemistry.

[6]  M. Umeda,et al.  Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids. , 1980, Mutation research.

[7]  J. Weisburger,et al.  Formation of mutagens in cooked foods. I. Beef. , 1979, Cancer letters.

[8]  E. V. Sydow,et al.  AROMA OF CANNED BEEF: GAS CHROMATOGRAPHIC AND MASS SPECTROMETRIC ANALYSIS OF THE VOLATILES , 1973 .

[9]  T. Shibamoto,et al.  Mutagenicity of products obtained from cysteamine--glucose browning model systems. , 1980, Journal of agricultural and food chemistry.

[10]  W. Powrie,et al.  Clastogenic activity of dried fruits. , 1981, Cancer letters.

[11]  T. Sugimura,et al.  Mutagens in coffee and tea. , 1979, Mutation research.

[12]  H. Stich,et al.  DNA repair and chromatid anomalies in mammalian cells exposed to 4-nitroquinoline 1-oxide , 1970 .

[13]  W. Powrie,et al.  Clastogenic activity of caramel and caramelized sugars. , 1981, Mutation research.

[14]  J. Maga.  Furans in foods. , 1979, CRC critical reviews in food science and nutrition.

[15]  V. Feron.  Respiratory tract tumors in hamsters after intratracheal instillations of benzo(a)pyrene alone and with furfural. , 1972, Cancer research.

[16]  L. Bjeldanes,et al.  Mutagenicity of 1,2-dicarbonyl compounds: maltol, kojic acid, diacetyl and related substances. , 1979, Mutation research.