Localized and propagating surface plasmon resonance based fiber optic sensor for the detection of tetracycline using molecular imprinting

In the present study we report a novel approach for the fabrication of localized and propagating surface plasmon resonance based fiber optic sensor for the detection of tetracycline using molecular imprinting (MIP) technique. The sensor is fabricated by coating layers of silver film, silver nanoparticles and MIP film prepared using tetracycline molecule as template over an unclad core of the multimode optical fiber. Nanoparticles of sizes in the range 10–30 nm are synthesized by hydrothermal process. A polychromatic light source is used to launch the light from one end of the fiber and the absorption spectrum for a given concentration of the tetracycline solution around the probe is measured at the other end of the fiber using a spectrometer interfaced with a computer. The absorption spectra are recorded for the concentration range of tetracycline from 10−8 M to 10−5 M. A shift of 102 nm in peak absorbance wavelength is obtained for this concentration range. The sensor works in the promising concentration range of tetracycline found in foods etc. The sensor has various advantages such as high sensitivity, low cost, fast response and capability of online monitoring and remote sensing. Further, the sensitivity of the sensor is about double the sensor based on localized surface plasmon resonance and molecular imprinting.

[1]  Banshi D Gupta,et al.  Surface plasmon resonance based fiber optic pH sensor utilizing Ag/ITO/Al/hydrogel layers. , 2013, The Analyst.

[2]  Y. Ci,et al.  Spectrofluorimetric determination of tetracycline and anhydrotetracycline in serum and urine. , 1992, The Analyst.

[3]  정원조.  Molecular imprinted polymers for separation science: A review of reviews , 2013 .

[4]  S. Schwarz,et al.  Use of antimicrobials in veterinary medicine and mechanisms of resistance. , 2001, Veterinary research.

[5]  Seema B. Sharma,et al.  Green Synthesis of Silver Nanoparticles Using Extracts of Ananas comosus , 2012 .

[6]  Li‐Ping Yu,et al.  A molecularly imprinted photonic polymer sensor with high selectivity for tetracyclines analysis in food. , 2012, The Analyst.

[7]  Banshi D. Gupta,et al.  Surface plasmon resonance based fiber optic hydrogen sulphide gas sensor utilizing nickel oxide doped ITO thin film , 2014 .

[8]  J. Homola.  Present and future of surface plasmon resonance biosensors , 2003, Analytical and bioanalytical chemistry.

[9]  Faiz Ali,et al.  Molecular imprinted polymers for separation science: a review of reviews. , 2013, Journal of separation science.

[10]  D. Barceló,et al.  Determination of tetracycline antibiotic residues in edible swine tissues by liquid chromatography with spectrofluorometric detection and confirmation by mass spectrometry. , 2007, Journal of agricultural and food chemistry.

[11]  Kiyotaka Sakai,et al.  Influence of solvents on chiral discriminative gate effect of molecularly imprinted poly(ethylene glycol dimethacrylate-co-methacrylic acid) , 2007 .

[12]  Zhiyong Guo,et al.  Development of an ultrasensitive electrochemiluminescence inhibition method for the determination of tetracyclines. , 2011, Analytica chimica acta.

[13]  G McHale,et al.  Molecular-imprinted, polymer-coated quartz crystal microbalances for the detection of terpenes. , 2001, Analytical chemistry.

[14]  F. Salinas,et al.  Determination of oxytetracycline and doxycycline in pharmaceutical compounds, urine and honey by derivative spectrophotometry. , 1989, The Analyst.

[15]  E. Stobberingh,et al.  Epidemiology of resistance to antibiotics. Links between animals and humans. , 2000, International journal of antimicrobial agents.

[16]  S. S. Badawy,et al.  Determination of tetracycline and related compounds using plastic membrane ion-selective electrodes , 1987 .

[17]  Jonathan M. Slater,et al.  The determination of tetracycline residues in food using a disposable screen-printed gold electrode (SPGE) , 2007 .

[18]  J. Hafner,et al.  Localized surface plasmon resonance sensors. , 2011, Chemical reviews.

[19]  D. Djozan,et al.  Preparation of new solid phase micro extraction fiber on the basis of atrazine-molecular imprinted polymer: application for GC and GC/MS screening of triazine herbicides in water, rice and onion. , 2008, Analytica chimica acta.

[20]  B. D. Gupta,et al.  Surface plasmon resonance based fiber optic sensor for the IR region using a conducting metal oxide film. , 2010, Journal of the Optical Society of America. A, Optics, image science, and vision.

[21]  Banshi D. Gupta,et al.  Surface plasmon resonance based fiber optic sensor for the detection of CrO42− using Ag/ITO/hydrogel layers , 2014 .

[22]  L. Yong-qing,et al.  Electrostatic field effects on three-dimensional topological insulators , 2013 .

[23]  Banshi D. Gupta,et al.  Absorption-based fiber optic surface plasmon resonance sensor: a theoretical evaluation , 2004 .

[24]  Roli Verma,et al.  Optical fiber sensor for the detection of tetracycline using surface plasmon resonance and molecular imprinting. , 2013, The Analyst.

[25]  Juan Zou,et al.  Controlled growth of silver nanoparticles in a hydrothermal process , 2007 .

[26]  W. A. Moats.  Determination of tetracycline antibiotics in tissues and blood serum of cattle and swine by high-performance liquid chromatography. , 1986, Journal of chromatography.

[27]  S. Yee,et al.  A fiber-optic chemical sensor based on surface plasmon resonance , 1993 .