Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

[1]  Terje Johansen,et al.  p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death , 2005, The Journal of cell biology.

[2]  N. Mizushima.  The pleiotropic role of autophagy: from protein metabolism to bactericide , 2005, Cell Death and Differentiation.

[3]  Atsushi Iwata,et al.  Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Masaaki Komatsu,et al.  Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice , 2005, The Journal of cell biology.

[5]  N. Heintz,et al.  Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair , 2005, Autophagy.

[6]  D. Klionsky.  The molecular machinery of autophagy: unanswered questions , 2005, Journal of Cell Science.

[7]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[8]  Mark R. Segal,et al.  Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death , 2004, Nature.

[9]  A. Yoshimura,et al.  Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity , 2004, Nature Medicine.

[10]  Francesco Scaravilli,et al.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease , 2004, Nature Genetics.

[11]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[12]  Takeshi Iwatsubo,et al.  Aggresomes Formed by α-Synuclein and Synphilin-1 Are Cytoprotective* , 2004, Journal of Biological Chemistry.

[13]  A. Cuervo.  Autophagy: in sickness and in health. , 2004, Trends in cell biology.

[14]  T. Kikuchi,et al.  Axonal degeneration of ascending sensory neurons in gracile axonal dystrophy mutant mouse , 2004, Acta Neuropathologica.

[15]  L. Notterpek,et al.  Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells , 2003, The Journal of Neuroscience.

[16]  Fumiaki Tanaka,et al.  Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. , 2003, Human molecular genetics.

[17]  L. Lossi,et al.  Synapse-independent and synapse-dependent apoptosis of cerebellar granule cells in postnatal rabbits occur at two subsequent but partly overlapping developmental stages , 2002, Neuroscience.

[18]  Rainer Duden,et al.  Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. , 2002, Human molecular genetics.

[19]  Takeshi Tokuhisa,et al.  Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells , 2001, The Journal of cell biology.

[20]  R. Kopito,et al.  Aggresomes, inclusion bodies and protein aggregation. , 2000, Trends in cell biology.

[21]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[22]  S. Hersch,et al.  Huntingtin aggregates may not predict neuronal death in Huntington's disease , 1999 .

[23]  S. Hersch,et al.  Huntington aggregates may not predict neuronal death in Huntington's disease. , 1999, Annals of neurology.

[24]  Steven Finkbeiner,et al.  Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions , 1998, Cell.

[25]  J. Miyazaki,et al.  A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. , 1997, Biochemical and biophysical research communications.

[26]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[27]  Werner Müller,et al.  Bypass of lethality with mosaic mice generated by Cre–loxP-mediated recombination , 1996, Current Biology.

[28]  M Aguet,et al.  Inducible gene targeting in mice , 1995, Science.

[29]  J. Julien,et al.  Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis , 1993, Cell.

[30]  K. Mikoshiba,et al.  Stacks of flattened smooth endoplasmic reticulum highly enriched in inositol 1,4,5-trisphosphate (InsP3) receptor in mouse cerebellar Purkinje cells. , 1991, Cell structure and function.

[31]  C. Sotelo.  Axonal abnormalities in cerebellar Purkinje cells of the ‘hyperspiny Purkinje cell’ mutant mouse , 1990, Journal of neurocytology.

[32]  A. Vinokur,et al.  "In Sickness and in Health" , 1990 .