Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

A genetic and pharmacological approach reveals novel insights into how changes in gut microbiota can subvert genetically predetermined phenotypes from lean to obese.

[1]  Ruth Ley,et al.  Unravelling the effects of the environment and host genotype on the gut microbiome , 2011, Nature Reviews Microbiology.

[2]  James Versalovic,et al.  Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll‐like receptor 2‐knockout mice , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  L. Putignani,et al.  Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. , 2010, Endocrine reviews.

[4]  S. Rabot,et al.  Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  H. Ellingsgaard,et al.  Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet , 2010, Diabetologia.

[6]  C. Smith,et al.  Tlr2 is critical for diet‐induced metabolic syndrome in a murine model , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  U. Boelsterli,et al.  Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[8]  M. Manco.  Endotoxin as a missed link among all the metabolic abnormalities in the metabolic syndrome. , 2009, Atherosclerosis.

[9]  T. Kaisho,et al.  Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model , 2009, British journal of pharmacology.

[10]  Philippe Froguel,et al.  The genetic contribution to non-syndromic human obesity , 2009, Nature Reviews Genetics.

[11]  G. La Torre,et al.  Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease , 2009, Hepatology.

[12]  T. van de Wiele,et al.  Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability , 2009, Gut.

[13]  I. Adlerberth,et al.  Establishment of the gut microbiota in Western infants , 2009, Acta paediatrica.

[14]  M. Myers,et al.  Endoplasmic reticulum stress plays a central role in development of leptin resistance. , 2009, Cell metabolism.

[15]  M. Patti,et al.  The emerging genetic architecture of type 2 diabetes. , 2008, Cell metabolism.

[16]  Ali Keshavarzian,et al.  Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. , 2008, Alcohol.

[17]  R. Bibiloni,et al.  Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice , 2008, Diabetes.

[18]  T. Nomura,et al.  Regulatory T Cells and Immune Tolerance , 2008, Cell.

[19]  M. Membrez,et al.  Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  Eliana P Araújo,et al.  Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. , 2007, Endocrinology.

[21]  J. Carvalheira,et al.  Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance , 2007, Diabetes.

[22]  J. Ferrières,et al.  Metabolic Endotoxemia Initiates Obesity and Insulin Resistance , 2007, Diabetes.

[23]  A. Rudensky,et al.  Foxp3 in control of the regulatory T cell lineage , 2007, Nature Immunology.

[24]  G Gerken,et al.  Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. , 2007, Gastroenterology.

[25]  S Kumar,et al.  Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. , 2007, American journal of physiology. Endocrinology and metabolism.

[26]  Christophe Benoist,et al.  Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. , 2007, Arthritis and rheumatism.

[27]  Parvez Hossain,et al.  Obesity and diabetes in the developing world--a growing challenge. , 2007, The New England journal of medicine.

[28]  Jeffrey I. Gordon,et al.  Mechanisms underlying the resistance to diet-induced obesity in germ-free mice , 2007, Proceedings of the National Academy of Sciences.

[29]  P. Turnbaugh,et al.  Microbial ecology: Human gut microbes associated with obesity , 2006, Nature.

[30]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[31]  Soonkyu Chung,et al.  Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. , 2006, Endocrinology.

[32]  J. Flier,et al.  TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.

[33]  Shuzhong Guo,et al.  The role of bifidobacteria in gut barrier function after thermal injury in rats. , 2006, The Journal of trauma.

[34]  J. B. Kim,et al.  Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. , 2006, Biochemical and biophysical research communications.

[35]  Claude Bouchard,et al.  The Human Obesity Gene Map: The 2005 Update , 2006, Obesity.

[36]  L. Joosten,et al.  Toll-like receptor 2 controls expansion and function of regulatory T cells. , 2006, The Journal of clinical investigation.

[37]  H. S. Warren,et al.  Toll-like receptors. , 2005, Critical care medicine.

[38]  C. Cherbut,et al.  Neonatal antibiotic treatment alters gastrointestinal tract developmental gene expression and intestinal barrier transcriptome. , 2005, Physiological genomics.

[39]  F. Bäckhed,et al.  Obesity alters gut microbial ecology. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[40]  K. Wellen,et al.  Inflammation, stress, and diabetes. , 2005, The Journal of clinical investigation.

[41]  E. Cario.  BACTERIAL INTERACTIONS WITH CELLS OF THE INTESTINAL MUCOSA: TOLL-LIKE RECEPTORS AND NOD2 , 2005, Gut.

[42]  T. Macdonald,et al.  Immunity, Inflammation, and Allergy in the Gut , 2005, Science.

[43]  M. Lazar,et al.  How Obesity Causes Diabetes: Not a Tall Tale , 2005, Science.

[44]  Gerene M Denning,et al.  Potential role of endotoxin as a proinflammatory mediator of atherosclerosis. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[45]  B. Fagerberg,et al.  Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance , 2004, Diabetologia.

[46]  Ting Wang,et al.  The gut microbiota as an environmental factor that regulates fat storage. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[47]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[48]  B. Beutler,et al.  Inferences, questions and possibilities in Toll-like receptor signalling , 2004, Nature.

[49]  L. Duffy,et al.  In Vivo Effects of Bifidobacteria and Lactoferrin on Gut Endotoxin Concentration and Mucosal Immunity in Balb/c Mice , 2004, Digestive Diseases and Sciences.

[50]  I. C. Almeida,et al.  Role of Toll-Like Receptor 4 in Induction of Cell-Mediated Immunity and Resistance to Brucella abortus Infection in Mice , 2004, Infection and Immunity.

[51]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[52]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[53]  R. Landmann,et al.  Cooperation between toll‐like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram‐negative and gram‐positive bacteria , 2003, European journal of immunology.

[54]  Nigel J. Saunders,et al.  CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms , 2003, The Journal of experimental medicine.

[55]  C. Kahn,et al.  Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.

[56]  I. Roberts-Thomson,et al.  The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis , 2001, Gut.

[57]  S. Akira,et al.  Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. , 1999, Immunity.

[58]  C. Roberts,et al.  Diet-induced insulin resistance precedes other aspects of the metabolic syndrome. , 1998, Journal of applied physiology.

[59]  J. Dong,et al.  Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[60]  E. Bezirtzoglou.  The intestinal microflora during the first weeks of life. , 1997, Anaerobe.

[61]  B. Spiegelman,et al.  IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance , 1996, Science.

[62]  E. Van Obberghen,et al.  Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. , 1994, The Biochemical journal.

[63]  E. Van Obberghen,et al.  Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. , 1994, The Journal of biological chemistry.

[64]  R. Barnard,et al.  Effects of a high-fat, sucrose diet on serum insulin and related atherosclerotic risk factors in rats. , 1993, Atherosclerosis.

[65]  Susumu Tonegawa,et al.  RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.

[66]  G. Freeman,et al.  Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. , 1991, Cellular immunology.

[67]  R. Sartor,et al.  Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. , 1991, Gastroenterology.

[68]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[69]  S. O'farrell,et al.  The origin of O serotypes of Escherichia coli in babies after normal delivery , 1974, Journal of Hygiene.

[70]  J. Stockman,et al.  Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 , 2012 .

[71]  Y. Tsai,et al.  Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse , 2010, Diabetologia.

[72]  W. Frankel,et al.  Increased colonic luminal synthesis of butyric acid is associated with lowered colonic cell proliferation in piglets. , 2006, The Journal of nutrition.

[73]  A. Vercesi,et al.  Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. , 2006, Biochimica et biophysica acta.

[74]  A. Hevener,et al.  IKK-beta links inflammation to obesity-induced insulin resistance. , 2005, Nature medicine.

[75]  Andreas Wilke,et al.  phylogenetic and functional analysis of metagenomes , 2022 .