Structures of calcineurin and its complexes with immunophilins-immunosuppressants.

[1]  Rick B. Vega,et al.  The role of modulatory calcineurin-interacting proteins in calcineurin signaling. , 2003, Trends in cardiovascular medicine.

[2]  S. Schiaffino,et al.  Calcineurin signaling and neural control of skeletal muscle fiber type and size. , 2002, Trends in pharmacological sciences.

[3]  Lei Guo,et al.  Calreticulin in cardiac development and pathology. , 2002, Biochimica et biophysica acta.

[4]  S. Harrison,et al.  Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Hwa-Young Kim,et al.  Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Molkentin,et al.  Calcineurin and cardiac hypertrophy: Where have we been? Where are we going? , 2002, The Journal of physiology.

[7]  M. Periasamy Calcineurin and the heartbeat, an evolving story. , 2002, Journal of molecular and cellular cardiology.

[8]  P. Doevendans,et al.  Calcineurin and hypertrophic heart disease: novel insights and remaining questions. , 2002, Cardiovascular research.

[9]  Weiguo Zhang Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy. , 2002, Cardiovascular research.

[10]  C. Klee,et al.  There is communication between all four Ca(2+)-bindings sites of calcineurin B. , 2001, Biochemistry.

[11]  J. Heitman,et al.  Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans , 2001, Molecular microbiology.

[12]  G. Crabtree Calcium, Calcineurin, and the Control of Transcription* , 2001, The Journal of Biological Chemistry.

[13]  C. Klee,et al.  Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A. , 2000, Biochemistry.

[14]  A. Rosenzweig,et al.  Structure of the bacteriophage lambda Ser/Thr protein phosphatase with sulfate ion bound in two coordination modes. , 2000, Biochemistry.

[15]  Rick B. Vega,et al.  A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling* , 2000, The Journal of Biological Chemistry.

[16]  C. Page,et al.  Airway nerves and protein phosphatases. , 1999, General pharmacology.

[17]  J. Heitman,et al.  Calcineurin , 2007, Cell Biochemistry and Biophysics.

[18]  M. Hoekstra,et al.  AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region* , 1998, The Journal of Biological Chemistry.

[19]  J. Heitman,et al.  Signal-transduction cascades as targets for therapeutic intervention by natural products. , 1998, Trends in biotechnology.

[20]  H. Okamura,et al.  Two-site Interaction of Nuclear Factor of Activated T Cells with Activated Calcineurin* , 1998, The Journal of Biological Chemistry.

[21]  S. Snyder,et al.  Cain, A Novel Physiologic Protein Inhibitor of Calcineurin* , 1998, The Journal of Biological Chemistry.

[22]  S. Izumo,et al.  Calcineurin—the missing link in cardiac hypertrophy , 1998, Nature Medicine.

[23]  Hao Ren,et al.  Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin* , 1998, The Journal of Biological Chemistry.

[24]  Jeffrey Robbins,et al.  A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy , 1998, Cell.

[25]  G. Nolan Cardiac development: Transcription and the broken heart , 1998, Nature.

[26]  Eric R Kandel,et al.  Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory , 1998, Cell.

[27]  E. Kandel,et al.  Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin , 1998, Cell.

[28]  G. Fink,et al.  Calcium control of adenylyl cyclase: the calcineurin connection. , 1998, Advances in second messenger and phosphoprotein research.

[29]  J. Tumlin Expression and function of calcineurin in the mammalian nephron: physiological roles, receptor signaling, and ion transport. , 1997, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[30]  P. Cohen,et al.  Novel protein serine/threonine phosphatases: variety is the spice of life. , 1997, Trends in biochemical sciences.

[31]  D. Barford,et al.  Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. , 1996, The EMBO journal.

[32]  D. Barford Molecular mechanisms of the protein serine/threonine phosphatases. , 1996, Trends in biochemical sciences.

[33]  J. Heitman,et al.  Calcineurin mutants render T lymphocytes resistant to cyclosporin A. , 1996, Molecular Pharmacology.

[34]  R. Fröhlich,et al.  Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures. , 1996, Journal of molecular biology.

[35]  A. Means,et al.  Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation. , 1996, Progress in cell cycle research.

[36]  Anna Tempczyk,et al.  Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex , 1995, Nature.

[37]  R. Kincaid The role of calcineurin in immune system responses. , 1995, The Journal of allergy and clinical immunology.

[38]  J. Dixon,et al.  Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1. , 1995, Structure.

[39]  Paul Greengard,et al.  Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1 , 1995, Nature.

[40]  P. Caron,et al.  X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex , 1995, Cell.

[41]  P. Tucker,et al.  Crystal structure of a purple acid phosphatase containing a dinuclear Fe(III)-Zn(II) active site. , 1995, Science.

[42]  R. S. Muir,et al.  Targets of immunophilin‐immunosuppressant complexes are distinct highly conserved regions of calcineurin A. , 1995, The EMBO journal.

[43]  L. Langeberg,et al.  Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. , 1995, Science.

[44]  J. C. Clemens,et al.  Mutational analysis of a Ser/Thr phosphatase. Identification of residues important in phosphoesterase substrate binding and catalysis. , 1994, The Journal of biological chemistry.

[45]  S. Schreiber,et al.  Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. , 1994, Structure.

[46]  William Arbuthnot Sir Lane,et al.  Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. , 1993, Science.

[47]  T. Curran,et al.  The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun , 1993, Nature.

[48]  C. Sander,et al.  Protein structure comparison by alignment of distance matrices. , 1993, Journal of molecular biology.

[49]  M. Walkinshaw,et al.  X-ray structure of a decameric cyclophilin-cyclosporin crystal complex , 1993, Nature.

[50]  Y. Thériault,et al.  Solution structure of the cyclosporin A/cyclophilin complex by NMR , 1993, Nature.

[51]  R. Kincaid Calmodulin-dependent protein phosphatases from microorganisms to man. A study in structural conservatism and biological diversity. , 1993, Advances in second messenger and phosphoprotein research.

[52]  S. Schreiber Immunophilin-sensitive protein phosphatase action in cell signaling pathways , 1992, Cell.

[53]  G. Crabtree,et al.  Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation , 1992, Nature.

[54]  E. A. O'neill,et al.  FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin , 1992, Nature.

[55]  C. Walsh,et al.  Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[56]  J. Friedman,et al.  Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA , 1991, Cell.

[57]  Stuart L. Schreiber,et al.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes , 1991, Cell.

[58]  R F Standaert,et al.  Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex , 1991, Science.

[59]  T. Takeda,et al.  The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A. , 1989, Biochemical and biophysical research communications.

[60]  M. King,et al.  The calmodulin-dependent activation and deactivation of the phosphoprotein phosphatase, calcineurin, and the effect of nucleotides, pyrophosphate, and divalent metal ions. Identification of calcineurin as a Zn and Fe metalloenzyme. , 1984, The Journal of biological chemistry.