Engineered antibody fragments and the rise of single domains
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[1] John W. Park,et al. Preclinical Manufacture of Anti‐HER2 Liposome‐Inserting, scFv‐PEG‐Lipid Conjugate. 2. Conjugate Micelle Identity, Purity, Stability, and Potency Analysis , 2008, Biotechnology progress.
[2] H. Rammensee,et al. Supraagonistic, bispecific single‐chain antibody purified from the serum of cloned, transgenic cows induces T‐cell‐mediated killing of glioblastoma cells in vitro and in vivo , 2005, International journal of cancer.
[3] P. D. de Groot,et al. A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B. , 2005, Blood.
[4] H. Kosmehl,et al. Engineered vascular‐targeting antibody‐interferon‐γ fusion protein for cancer therapy , 2005 .
[5] Andreas Plückthun,et al. Engineered proteins as specific binding reagents. , 2005, Current opinion in biotechnology.
[6] L. Wyns,et al. Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH. , 2005, Journal of molecular biology.
[7] S. Gambhir,et al. Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging. , 2005, Cancer research.
[8] Ziding Feng,et al. Optimized Normalization for Antibody Microarrays and Application to Serum-Protein Profiling*S , 2005, Molecular & Cellular Proteomics.
[9] D. Hicklin,et al. A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity* , 2005, Journal of Biological Chemistry.
[10] P. Hoffmann,et al. Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct , 2005, International journal of cancer.
[11] Mengji Lu,et al. Immunization with the Gene Expressing Woodchuck Hepatitis Virus Nucleocapsid Protein Fused to Cytotoxic-T-Lymphocyte-Associated Antigen 4 Leads to Enhanced Specific Immune Responses in Mice and Woodchucks , 2005, Journal of Virology.
[12] G. Vriend,et al. Induced refolding of a temperature denatured llama heavy‐chain antibody fragment by its antigen , 2005, Proteins.
[13] Laurent Chiche,et al. New binding specificities derived from Min-23, a small cystine-stabilized peptidic scaffold. , 2005, Biochemistry.
[14] Michael Wunderlich,et al. Stabilization of the cold shock protein CspB from Bacillus subtilis by evolutionary optimization of Coulombic interactions. , 2005, Journal of molecular biology.
[15] K. Christopher Garcia,et al. Structure of a γδ T Cell Receptor in Complex with the Nonclassical MHC T22 , 2005, Science.
[16] L. Wyns,et al. Strong in Vivo Maturation Compensates for Structurally Restricted H3 Loops in Antibody Repertoires* , 2005, Journal of Biological Chemistry.
[17] S. Shen,et al. Patient-specific dosimetry of pretargeted radioimmunotherapy using CC49 fusion protein in patients with gastrointestinal malignancies. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[18] R. Kimmig,et al. Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct. , 2005, Cancer research.
[19] R. Ober,et al. From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling. , 2005, Molecular biology of the cell.
[20] A. Arnold,et al. T-cell triggering by CD3- and CD28-binding molecules linked to a human virus-modified tumor cell vaccine. , 2005, Vaccine.
[21] Michael P. Levens,et al. Engineering high affinity superantigens by phage display. , 2005, Journal of molecular biology.
[22] W. Wels,et al. A novel bispecific tetravalent antibody fusion protein to target costimulatory activity for T-cell activation to tumor cells overexpressing ErbB2/HER2. , 2005, Journal of molecular biology.
[23] Targeting malignant B‐cell lymphoma with a humanized anti‐CD22 scFv‐angiogenin immunoenzyme ‡ , 2005, British journal of haematology.
[24] M. Flajnik,et al. Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum , 2005, European journal of immunology.
[25] D. Vallera,et al. Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice. , 2005, Leukemia research.
[26] P. Linsley. New look at an old costimulator , 2005, Nature Immunology.
[27] Dan Lu,et al. A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3 , 2005, Molecular Cancer Therapeutics.
[28] Jing Wu,et al. Augmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor , 2005, Cancer biology & therapy.
[29] V. Streltsov,et al. Do sharks have a new antibody lineage? , 2005, Immunology letters.
[30] Mohan Doss,et al. Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody. , 2005, Cancer research.
[31] I. Pastan,et al. HA22 (R490A) Is a Recombinant Immunotoxin with Increased Antitumor Activity without an Increase in Animal Toxicity , 2005, Clinical Cancer Research.
[32] D. Stuart,et al. Crystal structure of a soluble CD28-Fab complex , 2005, Nature Immunology.
[33] Ross S Chambers,et al. High-throughput antibody production. , 2005, Current opinion in chemical biology.
[34] S. Batra,et al. The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs. , 2005, Nuclear medicine and biology.
[35] Renate Kunert,et al. Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. , 2005, Immunity.
[36] C. James,et al. Rescue and propagation of fully retargeted oncolytic measles viruses , 2005, Nature Biotechnology.
[37] D. Lauffenburger,et al. Integrating cell-level kinetic modeling into the design of engineered protein therapeutics , 2005, Nature Biotechnology.
[38] S. Gambhir,et al. Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics , 2005, Science.
[39] Sanjiv S Gambhir,et al. Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments. , 2005, Cancer research.
[40] R. Begent,et al. Sustained tumor regression of human colorectal cancer xenografts using a multifunctional mannosylated fusion protein in antibody-directed enzyme prodrug therapy. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[41] G. Vriend,et al. Isolation of Llama Antibody Fragments for Prevention of Dandruff by Phage Display in Shampoo , 2005, Applied and Environmental Microbiology.
[42] B. Shen,et al. A new format of bispecific antibody: highly efficient heterodimerization, expression and tumor cell lysis. , 2005, Journal of immunological methods.
[43] E. Adams,et al. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. , 2005, Science.
[44] H. Kosmehl,et al. Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy. , 2005, International journal of cancer.
[45] D. Goldenberg,et al. Perspectives on cancer therapy with radiolabeled monoclonal antibodies. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[46] David W. Colby,et al. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[47] S. Rybak,et al. Antigen binding and stability properties of non‐covalently linked anti‐CD22 single‐chain Fv dimers , 2004, FEBS letters.
[48] L. Wyns,et al. Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody* , 2004, Journal of Biological Chemistry.
[49] Serge Muyldermans,et al. Single Domain Antibodies Derived from Dromedary Lymph Node and Peripheral Blood Lymphocytes Sensing Conformational Variants of Prostate-specific Antigen* , 2004, Journal of Biological Chemistry.
[50] T. Lüscher,et al. Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody Against the Extra-Domain B of Fibronectin , 2004, Circulation research.
[51] K. Chester,et al. Engineered single chain antibody fragments for radioimmunotherapy. , 2004, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....
[52] A L Ghindilis,et al. Immunoassays based on electrochemical detection using microelectrode arrays. , 2004, Biosensors & bioelectronics.
[53] R. Jordan,et al. Pharmacodynamic enhancement of the anti-platelet antibody Fab abciximab by site-specific pegylation , 2004, Platelets.
[54] Uwe Karsten,et al. Multivalent scFv display of phagemid repertoires for the selection of carbohydrate-specific antibodies and its application to the Thomsen-Friedenreich antigen. , 2004, Journal of molecular biology.
[55] B Tidor,et al. Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody. , 2004, Journal of molecular biology.
[56] H. Goldschmidt,et al. Combined effect of recombinant CD19×CD16 diabody and thalidomide in a preclinical model of human B cell lymphoma , 2004, Anti-cancer drugs.
[57] G. Winter,et al. Selection of optical biosensors from chemisynthetic antibody libraries. , 2004, Protein engineering, design & selection : PEDS.
[58] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[59] K Dane Wittrup,et al. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. , 2004, Journal of molecular biology.
[60] I. Wilson,et al. Crystal Structure of a Shark Single-Domain Antibody V Region in Complex with Lysozyme , 2004, Science.
[61] P. Parren,et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. , 2004, Blood.
[62] M. Brechbiel,et al. A Single Treatment of Yttrium-90-labeled CHX-A″–C6.5 Diabody Inhibits the Growth of Established Human Tumor Xenografts in Immunodeficient Mice , 2004, Cancer Research.
[63] Dennis R. Burton,et al. Identification and Characterization of a New Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody , 2022 .
[64] J. Varghese,et al. Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[65] Carolyn R. Bertozzi,et al. Chemical remodelling of cell surfaces in living animals , 2004, Nature.
[66] G. Winter,et al. Aggregation-resistant domain antibodies selected on phage by heat denaturation , 2004, Nature Biotechnology.
[67] L. Dinkelborg,et al. Molecular targeting of angiogenesis for imaging and therapy , 2004, European Journal of Nuclear Medicine and Molecular Imaging.
[68] T. Allen,et al. Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs. , 2004, Journal of the National Cancer Institute.
[69] Paul J Yazaki,et al. Pilot Trial Evaluating an 123I-Labeled 80-Kilodalton Engineered Anticarcinoembryonic Antigen Antibody Fragment (cT84.66 Minibody) in Patients with Colorectal Cancer , 2004, Clinical Cancer Research.
[70] T. Rabbitts,et al. Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules. , 2004, Current molecular medicine.
[71] D. Burton,et al. Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[72] C. Demangel,et al. Targeting Dendritic Cells with Antigen-Containing Liposomes , 2004, Cancer Research.
[73] Yan Li,et al. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy , 2004, Nature.
[74] R. Kontermann,et al. Recombinant bispecific antibodies for the targeting of adenoviruses to CEA‐expressing tumour cells: a comparative analysis of bacterially expressed single‐chain diabody and tandem scFv , 2004, The journal of gene medicine.
[75] S. Sharma,et al. Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT) , 2004, British Journal of Cancer.
[76] S. Muyldermans,et al. An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostate-specific antigen by surface plasmon resonance technology. , 2004, Bioconjugate chemistry.
[77] Serge Muyldermans,et al. Efficient cancer therapy with a nanobody-based conjugate. , 2004, Cancer research.
[78] L. James,et al. Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold. , 2004, Journal of molecular biology.
[79] Jinha M. Park,et al. Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting. , 2004, Protein engineering, design & selection : PEDS.
[80] M. Foley,et al. Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1 , 2004, Proteins.
[81] M. Little,et al. Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody. , 2004, Protein engineering, design & selection : PEDS.
[82] F. Legall,et al. Recent advances in the generation of bispecific antibodies for tumor immunotherapy. , 2004 .
[83] S. Russell,et al. Antibody-targeted cell fusion , 2004, Nature Biotechnology.
[84] L. Álvarez-Vallina,et al. Antibodies and gene therapy: teaching old 'magic bullets' new tricks. , 2004, Trends in immunology.
[85] Dennis R. Burton,et al. Human antibody–Fc receptor interactions illuminated by crystal structures , 2004, Nature Reviews Immunology.
[86] T. Dottorini,et al. Crystal structure of a human VH: requirements for maintaining a monomeric fragment. , 2004, Biochemistry.
[87] L. Wyns,et al. Efficient Targeting of Conserved Cryptic Epitopes of Infectious Agents by Single Domain Antibodies , 2004, Journal of Biological Chemistry.
[88] T. L. Brown,et al. MTS-conjugated-antiactive caspase 3 antibodies inhibit actinomycin D-induced apoptosis , 2003, Apoptosis.
[89] K. Medzihradszky,et al. Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein. , 2003, Glycobiology.
[90] S. Kipriyanov,et al. Recent advances in the generation of bispecific antibodies for tumor immunotherapy. , 2004, Current opinion in drug discovery & development.
[91] S. Gambhir,et al. Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications. , 2004, Protein engineering, design & selection : PEDS.
[92] W. Mcbride,et al. Reagents and methods for PET using bispecific antibody pretargeting and 68Ga-radiolabeled bivalent hapten-peptide-chelate conjugates. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[93] P. Rosenthal,et al. Structure of an influenza neuraminidase-diabody complex by electron cryomicroscopy and image analysis. , 2003, Journal of molecular biology.
[94] Sanjiv S Gambhir,et al. 124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[95] Junho Chung,et al. Intradiabodies, Bispecific, Tetravalent Antibodies for the Simultaneous Functional Knockout of Two Cell Surface Receptors* , 2003, Journal of Biological Chemistry.
[96] W. Gibson. Faculty Opinions recommendation of Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. , 2003 .
[97] R. Klemenz,et al. Single-chain antibody and its derivatives directed against vascular endothelial growth factor: application for antiangiogenic gene therapy , 2003, Gene Therapy.
[98] P. Hudson,et al. Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70. , 2003, European journal of biochemistry.
[99] T. Rabbitts,et al. Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies. , 2003, Journal of molecular biology.
[100] R. Vile,et al. Induction of Human T Lymphocyte Cytotoxicity and Inhibition of Tumor Growth by Tumor-Specific Diabody-Based Molecules Secreted from Gene-Modified Bystander Cells1 , 2003, The Journal of Immunology.
[101] Carl W. Miller,et al. Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells. , 2003, Cancer letters.
[102] J. Rizo,et al. Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice , 2003, Nature Biotechnology.
[103] T. Rabbitts,et al. De novo production of diverse intracellular antibody libraries. , 2003, Nucleic acids research.
[104] Dan S. Tawfik,et al. Antibody Multispecificity Mediated by Conformational Diversity , 2003, Science.
[105] A. Wu,et al. The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility. , 2003, Journal of molecular biology.
[106] Olan Dolezal,et al. Single-chain Fv multimers of the anti-neuraminidase antibody NC10: the residue at position 15 in the V(L) domain of the scFv-0 (V(L)-V(H)) molecule is primarily responsible for formation of a tetramer-trimer equilibrium. , 2003, Protein engineering.
[107] A. Kortt,et al. Generation of recombinant multimeric antibody fragments for tumor diagnosis and therapy. , 2003, Methods in molecular biology.
[108] P. Hudson,et al. Engineered antibodies , 2003, Nature Medicine.
[109] Dan S. Tawfik,et al. Microbead display by in vitro compartmentalisation: selection for binding using flow cytometry , 2002, FEBS Letters.
[110] A. Nesbitt,et al. Formatting antibody fragments to mediate specific therapeutic functions. , 2002, Biochemical Society transactions.
[111] T. Waldmann,et al. Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213. , 2002, Blood.
[112] Jennifer L Ong,et al. Isolation of receptor–ligand pairs by capture of long-lived multivalent interaction complexes , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[113] L. Hope-Stone,et al. Tumour targeting of humanised cross-linked divalent-fab′ antibody fragments: a clinical phase I/II study , 2002, British Journal of Cancer.
[114] C. Halin,et al. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature , 2002, Nature Biotechnology.
[115] M. Dohlsten,et al. Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen , 2001, British Journal of Cancer.
[116] P. Carter,et al. Bispecific human IgG by design. , 2001, Journal of immunological methods.
[117] U. Nielsen,et al. Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. , 2000, Cancer research.
[118] V. Diehl,et al. Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins. , 1999, Cancer research.
[119] T. Orntoft,et al. Clinical aspects of altered glycosylation of glycoproteins in cancer , 1999, Electrophoresis.
[120] A. Murzin,et al. The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[121] G. Winter,et al. Retargeting serum immunoglobulin with bispecific diabodies , 1997, Nature Biotechnology.
[122] P. Iliades,et al. Triabodies: single chain Fv fragments without a linker form trivalent trimers , 1997, FEBS letters.
[123] L. Presta,et al. Remodeling domain interfaces to enhance heterodimer formation , 1997, Protein science : a publication of the Protein Society.
[124] P. McCarthy,et al. A clinical phase I/II study of recombinant human interleukin-1 receptor in glucocorticoid-resistant graft-versus-host disease. , 1996, Transplantation.
[125] T Prospero,et al. "Diabodies": small bivalent and bispecific antibody fragments. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[126] K. Fujimori,et al. Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: the radiation dose distribution. , 1991, Cancer research.
[127] P. T. Jones,et al. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli , 1989, Nature.
[128] R K Jain,et al. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. , 1988, Cancer research.
[129] K. D. Hardman,et al. Single-chain antigen-binding proteins. , 1988, Science.
[130] R. Bruccoleri,et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[131] R. R. Robinson,et al. Escherichia coli secretion of an active chimeric antibody fragment. , 1988, Science.