Elucidating mechanisms underlying robustness of morphogen gradients.

Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds. We refer to the capacity to buffer fluctuations in gene dosage or environmental conditions as 'robustness'. By theoretical analysis of mechanisms that facilitate robustness, it is possible to unravel the machinery responsible for generating the spatial distribution of morphogens.

[1]  E. L. Ferguson,et al.  Spatially Restricted Activation of the SAX Receptor by SCW Modulates DPP/TKV Signaling in Drosophila Dorsal–Ventral Patterning , 1998, Cell.

[2]  G. Odell,et al.  The segment polarity network is a robust developmental module , 2000, Nature.

[3]  G. Odell,et al.  Design and constraints of the Drosophila segment polarity module: robust spatial patterning emerges from intertwined cell state switches. , 2002, The Journal of experimental zoology.

[4]  Nicholas T Ingolia,et al.  Topology and Robustness in the Drosophila Segment Polarity Network , 2004, PLoS biology.

[5]  C. Waddington.  Canalization of Development and the Inheritance of Acquired Characters , 1942, Nature.

[6]  L Wolpert,et al.  Mechanisms for positional signalling by morphogen transport: a theoretical study. , 1998, Journal of theoretical biology.

[7]  Isabel Guerrero,et al.  Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction , 2004, Development.

[8]  T. Kornberg,et al.  On the range of hedgehog signaling. , 2000, Current opinion in genetics & development.

[9]  L. Wolpert.  Positional information and the spatial pattern of cellular differentiation. , 1969, Journal of theoretical biology.

[10]  Naama Barkai,et al.  Self-enhanced ligand degradation underlies robustness of morphogen gradients. , 2003, Developmental cell.

[11]  K. Struhl,et al.  The gradient morphogen bicoid is a concentration-dependent transcriptional activator , 1989, Cell.

[12]  S. Leibler,et al.  Robustness in simple biochemical networks , 1997, Nature.

[13]  P. Swain,et al.  Stochastic Gene Expression in a Single Cell , 2002, Science.

[14]  Michael Levine,et al.  Local inhibition and long-range enhancement of Dpp signal transduction by Sog , 1999, Nature.

[15]  G. Odell,et al.  Robustness, Flexibility, and the Role of Lateral Inhibition in the Neurogenic Network , 2002, Current Biology.

[16]  L. Raftery,et al.  TGF-beta family signal transduction in Drosophila development: from Mad to Smads. , 1999, Developmental biology.

[17]  N. Barkai,et al.  Robustness of the BMP morphogen gradient in Drosophila embryonic patterning , 2022 .

[18]  E. L. Ferguson,et al.  Morphogen gradients: new insights from DPP. , 1999, Trends in genetics : TIG.

[19]  Yoshiki Sasai,et al.  A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin , 1995, Nature.

[20]  Qing Nie,et al.  Do morphogen gradients arise by diffusion? , 2002, Developmental cell.

[21]  Ken W. Y. Cho,et al.  Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins , 1997, Cell.

[22]  Sangbin Park,et al.  Interpretation of a BMP Activity Gradient in Drosophila Embryos Depends on Synergistic Signaling by Two Type I Receptors, SAX and TKV , 1998, Cell.

[23]  Tetsuya Tabata,et al.  Morphogens, their identification and regulation , 2004, Development.

[24]  S. Leibler,et al.  Establishment of developmental precision and proportions in the early Drosophila embryo , 2002, Nature.

[25]  R. Cerrone,et al.  Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration. , 1997, Development.

[26]  C. Nüsslein-Volhard,et al.  The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner , 1988, Cell.

[27]  Douglas A Lauffenburger,et al.  Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. , 2002, Development.