论文信息 - Airway Smooth Muscle Mechanics, Remodeling and Proliferation: Effects of Aicar and Metformin

Airway Smooth Muscle Mechanics, Remodeling and Proliferation: Effects of Aicar and Metformin

Obesity is a risk factor for asthma. The purpose of this study was to determine whether metformin, an agent used in the treatment of another obesity-related condition, type II diabetes, might have therapeutic potential for airway smooth muscle (ASM) function in obesity.

[1] S. Shore,et al. Obesity and asthma: directions for research. , 2004, American journal of respiratory and critical care medicine.

[2] Shailendra Giri,et al. 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase* , 2005, Journal of Biological Chemistry.

[3] J. Fredberg,et al. Obesity, smooth muscle, and airway hyperresponsiveness. , 2005, The Journal of allergy and clinical immunology.

[4] J. Fredberg,et al. Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell. , 2004, Journal of applied physiology.

[5] D. Hardie. Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0982 Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status , 2022 .

[6] Ben Fabry,et al. Cytoskeletal remodelling and slow dynamics in the living cell , 2005, Nature materials.

[7] R. Takeda,et al. AMP-Activated Protein Kinase Inhibits Angiotensin II– Stimulated Vascular Smooth Muscle Cell Proliferation , 2004, Circulation.