Immunometabolism in cancer at a glance
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[1] R. Davis,et al. Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy. , 2018, Cell metabolism.
[2] A. Neff,et al. Comparative metabolic analysis in head and neck cancer and the normal gingiva , 2018, Clinical Oral Investigations.
[3] M. Smyth,et al. Targeting immunosuppressive adenosine in cancer , 2017, Nature Reviews Cancer.
[4] David K. Finlay,et al. Srebp-controlled glucose metabolism is essential for NK cell functional responses , 2017, Nature Immunology.
[5] Liqin Zheng,et al. Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells , 2017, Oncoimmunology.
[6] Marc Hennequart,et al. Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance , 2017, Cancer Immunology Research.
[7] Kristie L. Rose,et al. Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation , 2017, PloS one.
[8] W. Rathmell,et al. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. , 2017, JCI insight.
[9] V. Tiriveedhi,et al. Inflammatory role of high salt level in tumor microenvironment (Review). , 2017, International journal of oncology.
[10] David K. Finlay,et al. What Fuels Natural Killers? Metabolism and NK Cell Responses , 2017, Front. Immunol..
[11] E. Tagliabue,et al. Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation. , 2017, Seminars in cancer biology.
[12] Zhi-Yao He,et al. Simultaneous enhancement of cellular and humoral immunity by the high salt formulation of Al(OH)3 adjuvant , 2017, Cell Research.
[13] J. Yu,et al. Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches , 2017, Oncogene.
[14] J. Woodgett,et al. GSK3 is a metabolic checkpoint regulator in B cells , 2016, Nature Immunology.
[15] S. Haferkamp,et al. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. , 2016, Cell metabolism.
[16] P. Carmeliet,et al. Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis. , 2016, Cell metabolism.
[17] P. Massion,et al. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. , 2016, Journal of immunological methods.
[18] M. Warmoes,et al. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression , 2016, Nature Immunology.
[19] J. Rathmell,et al. Nutrients and the microenvironment to feed a T cell army. , 2016, Seminars in immunology.
[20] S. Hanash,et al. The Emerging Role of B Cells in Tumor Immunity. , 2016, Cancer research.
[21] M. Mann,et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity , 2016, Cell.
[22] W. Linehan,et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function , 2016, Nature.
[23] Deborah S. Barkauskas,et al. Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses. , 2016, Cancer cell.
[24] G. Thomas,et al. Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma. , 2016, Cancer research.
[25] A. Richardson,et al. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine , 2016, Cell.
[26] Marcus Schmidt,et al. Feasibility of induced metabolic bioluminescence imaging in advanced ovarian cancer patients: first results of a pilot study , 2016, Journal of Cancer Research and Clinical Oncology.
[27] P. Oefner,et al. Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells , 2016, Oncoimmunology.
[28] V. Tiriveedhi,et al. Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells , 2016, Cell Biochemistry and Biophysics.
[29] R. Gillies,et al. Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy. , 2016, Cancer research.
[30] Ping-Chih Ho,et al. Metabolic communication in tumors: a new layer of immunoregulation for immune evasion , 2016, Journal of Immunotherapy for Cancer.
[31] D. Hafler,et al. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. , 2015, The Journal of clinical investigation.
[32] Caitlyn E. Bowman,et al. Preventing Allograft Rejection by Targeting Immune Metabolism. , 2015, Cell reports.
[33] Philippe A. Robert,et al. Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation , 2015, Science Signaling.
[34] V. De Rosa,et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants , 2015, Nature Immunology.
[35] R. Schreiber,et al. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression , 2015, Cell.
[36] J. Locasale,et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses , 2015, Cell.
[37] P. Oefner,et al. Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2‐deoxy‐glucose affects effector functions , 2015, European journal of immunology.
[38] M. Buck,et al. T cell metabolism drives immunity , 2015, The Journal of experimental medicine.
[39] M. Bui,et al. A phase-1/2 study of adenovirus-p53 transduced dendritic cell vaccine in combination with indoximod in metastatic solid tumors and invasive breast cancer , 2015, Oncotarget.
[40] F. D’Acquisto,et al. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions , 2015, PLoS biology.
[41] Juan R. Cubillos-Ruiz,et al. ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis , 2015, Cell.
[42] A. Oxenius,et al. The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration , 2015, Science.
[43] Jeremy J. W. Chen,et al. Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression , 2015, Scientific Reports.
[44] J. Rathmell,et al. T cell metabolic fitness in antitumor immunity. , 2015, Trends in immunology.
[45] David K. Finlay,et al. mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function , 2014, The Journal of Immunology.
[46] M. Smyth,et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. , 2014, Cancer research.
[47] G. Cline,et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.
[48] J. Rathmell,et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.
[49] E. Gilson,et al. The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation , 2014, Nature Immunology.
[50] Jae-Hoon Chang,et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. , 2014, Immunity.
[51] D. Green,et al. Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells , 2014, The Journal of Immunology.
[52] S. Gordon,et al. The M1 and M2 paradigm of macrophage activation: time for reassessment , 2014, F1000prime reports.
[53] M. Mazzone,et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. , 2013, Cancer cell.
[54] Sung Soo Kim,et al. Cancer cell metabolism: implications for therapeutic targets , 2013, Experimental & Molecular Medicine.
[55] T. Maeda,et al. Acidic extracellular microenvironment and cancer , 2013, Cancer Cell International.
[56] M. Smyth,et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors , 2013, Proceedings of the National Academy of Sciences.
[57] B. Faubert,et al. Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.
[58] J. Rathmell,et al. Metabolic regulation of T lymphocytes. , 2013, Annual review of immunology.
[59] J. Licht,et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. , 2013, Immunity.
[60] A. Regev,et al. Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 , 2013, Nature.
[61] Linda V. Sinclair,et al. Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation , 2013, Nature immunology.
[62] Bin Hu,et al. Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c‐Jun activation , 2012, International journal of cancer.
[63] I. Melero,et al. A Phase I Pharmacologic Study of Necitumumab (imc-11f8), a Fully Human Igg1 Monoclonal Antibody the Hif-1␣ Hypoxia Response in Tumor-infi Ltrating T Lymphocytes Induces Functional Cd137 (4-1bb) for Immunotherapy , 2022 .
[64] Hui Yang,et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. , 2012, Genes & development.
[65] Wei Gu,et al. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence , 2012, Cell.
[66] C. Uyttenhove,et al. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase , 2012, Proceedings of the National Academy of Sciences.
[67] Pal Pacher,et al. Adenosine promotes alternative macrophage activation via A2A and A2B receptors , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[68] M. Weller,et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor , 2011, Nature.
[69] G. Semenza,et al. Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 , 2011, Cell.
[70] M. Godejohann,et al. Metabolomics of B to plasma cell differentiation. , 2011, Journal of proteome research.
[71] K. Klotz,et al. Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity , 2011, Cancer Immunology, Immunotherapy.
[72] S. Jakobsen,et al. Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[73] B. Seliger,et al. Warburg phenotype in renal cell carcinoma: High expression of glucose‐transporter 1 (GLUT‐1) correlates with low CD8+ T‐cell infiltration in the tumor , 2011, International journal of cancer.
[74] J. Rathmell,et al. Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets , 2011, The Journal of Immunology.
[75] J. Fechner,et al. An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells , 2010, The Journal of Immunology.
[76] G. Semenza,et al. Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α–Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow , 2009, The Journal of Immunology.
[77] C. MacKenzie,et al. Antimicrobial and immunoregulatory properties of human tryptophan 2,3‐dioxygenase , 2009, European journal of immunology.
[78] Mark S. Sundrud,et al. Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response , 2009, Science.
[79] Jennifer E. Van Eyk,et al. c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2016 .
[80] D. Mougiakakos,et al. Transduction with the Antioxidant Enzyme Catalase Protects Human T Cells against Oxidative Stress1 , 2008, The Journal of Immunology.
[81] Anthony Mancuso,et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction , 2008, Proceedings of the National Academy of Sciences.
[82] T. Gajewski,et al. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells , 2008, European journal of immunology.
[83] J. Mora,et al. Vitamin effects on the immune system: vitamins A and D take centre stage , 2008, Nature Reviews Immunology.
[84] Silvia Maggini,et al. Contribution of Selected Vitamins and Trace Elements to Immune Function , 2007, Annals of Nutrition and Metabolism.
[85] Gregor Rothe,et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. , 2007, Blood.
[86] T. Gallart,et al. Role of glutamate on T-cell mediated immunity , 2007, Journal of Neuroimmunology.
[87] D. Quiceno,et al. L-arginine availability regulates T-lymphocyte cell-cycle progression. , 2007, Blood.
[88] F. Ciruela,et al. Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation1 , 2006, The Journal of Immunology.
[89] R. Wenger,et al. Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes , 2006, The Journal of Immunology.
[90] U. Grohmann,et al. The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 , 2006, The Journal of Immunology.
[91] G. Semenza,et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.
[92] J. Pollard,et al. Distinct role of macrophages in different tumor microenvironments. , 2006, Cancer research.
[93] Craig Murdoch,et al. Macrophage migration and gene expression in response to tumor hypoxia , 2005, International journal of cancer.
[94] B. Freedman,et al. Hypoxia inducible factor 1α regulates T cell receptor signal transduction , 2005 .
[95] B. Baban,et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. , 2005, Immunity.
[96] F. Ciruela,et al. Group I Metabotropic Glutamate Receptors Mediate a Dual Role of Glutamate in T Cell Activation* , 2004, Journal of Biological Chemistry.
[97] S. Tsugane,et al. Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women , 2004, British Journal of Cancer.
[98] S. Saccani,et al. Regulation of the Chemokine Receptor CXCR4 by Hypoxia , 2003, The Journal of experimental medicine.
[99] C. Uyttenhove,et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase , 2003, Nature Medicine.
[100] C. Lewis,et al. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. , 2003, The American journal of pathology.
[101] S. Colgan,et al. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. , 2002, The Journal of clinical investigation.
[102] C. Thompson,et al. The CD28 signaling pathway regulates glucose metabolism. , 2002, Immunity.
[103] A. Ohta,et al. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage , 2001, Nature.
[104] W. Sly,et al. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. , 2001, The American journal of pathology.
[105] W. Kreutz,et al. Acidic pH inhibits non-MHC-restricted killer cell functions. , 2000, Clinical immunology.
[106] W. Kreutz,et al. An Acidic Microenvironment Inhibits Antitumoral Non–Major Histocompatibility Complex-Restricted Cytotoxicity: Implications for Cancer Immunotherapy , 2000, Journal of immunotherapy.
[107] W. Kreutz,et al. An acidic microenvironment impairs the generation of non‐major histocompatibility complex‐restricted killer cells , 2000, Immunology.
[108] Steve Huang,et al. Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion , 1997 .
[109] J. Blay,et al. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. , 1997, Cancer research.
[110] G. Semenza,et al. Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1* , 1996, The Journal of Biological Chemistry.
[111] G. Semenza,et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.
[112] P. Anderson,et al. Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity , 1996, European journal of immunology.
[113] J. Crawford,et al. The essential role of L‐glutamine in lymphocyte differentiation in vitro , 1985, Journal of cellular physiology.
[114] Otto Warburn,et al. THE METABOLISM OF TUMORS , 1931 .
[115] O. Warburg,et al. THE METABOLISM OF TUMORS IN THE BODY , 1927, The Journal of general physiology.
[116] Marc Hennequart,et al. Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. , 2017, Cancer immunology research.
[117] Benjamin G. Gowen,et al. Recognition of tumors by the innate immune system and natural killer cells. , 2014, Advances in immunology.
[118] S. Colgan,et al. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. , 2009, Blood.
[119] H. Arimochi,et al. High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase , 2007, Journal of Molecular Neuroscience.
[120] M. Dewhirst,et al. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. , 2001, International journal of radiation oncology, biology, physics.
[121] Wei Liu,et al. Distinct involvement of NF‐κB and p38 mitogen‐activated protein kinase pathways in serum deprivation‐mediated stimulation of inducible nitric oxide synthase and its inhibition by 4‐hydroxynonenal , 2001, Journal of cellular biochemistry.