A systematic study of the pharmacological activities of dopamine antagonists.

Abstract The so-called dopamine (DA)-antagonists possess a wide variety of pharmacological activities. The present paper analyses some comparative data that were obtained in the Janssen Research Laboratories, using a large series of DA-antagonists in a representative set of pharmacological tests. This study illustrates the relative importance of the different pharmacological properties of these compounds, provides a tool for further meaningful pharmacological and biochemical research in this area, and discusses the therapeutic potential of these drugs.

[1]  J. Leysen,et al.  Is the low incidence of extrapyramidal side‐effects of antipsychotics associated with antimuscarinic properties? , 1978, The Journal of pharmacy and pharmacology.

[2]  M. Singh,et al.  THERAPEUTIC REVERSAL WITH BENZTROPINE IN SCHIZOPHRENICS: PRACTICAL AND THEORETICAL SIGNIFICANCE , 1975, The Journal of nervous and mental disease.

[3]  M. Singh,et al.  REVERSAL OF SOME THERAPEUTIC EFFECTS OF AN ANTIPSYCHOTIC AGENT BY AN ANTIPARKINSONISM DRUG , 1973, The Journal of nervous and mental disease.

[4]  V. J. Lotti,et al.  INDOLEAMINE ANTAGONISTS: RELATIVE POTENCIES AS INHIBITORS OF TRYPTAMINE‐ AND 5‐HYDROXYTRYPTOPHAN‐EVOKED RESPONSES , 1974, British journal of pharmacology.

[5]  A. Parlow,et al.  Human pituitary prolactin (hPRL): the entire linear amino acid sequence. , 1977, The Journal of clinical endocrinology and metabolism.

[6]  J. Leysen,et al.  A serotonergic component of neuroleptic receptors. , 1977, Archives internationales de pharmacodynamie et de therapie.

[7]  P. Bradley,et al.  Drugs and Central Synaptic Transmission , 1976 .

[8]  A. Weissman.  Penfluridol blockade of apomorphine: dependence of duration on species and endpoint. , 1975, European journal of pharmacology.

[9]  C. Niemegeers,et al.  Investigations on drug produced and subjectively experienced discriminative stimuli. I. The fentanyl cue, a tool to investigate subjectively experience narcotic drug actions. , 1975, Life sciences.

[10]  P. Borenstein,et al.  [Clinical and electroencephalographic effects of methoclopramide in psychiatry]. , 1965, Therapie.

[11]  D. H. Tedeschi,et al.  The effects of tryptamine on the central nervous system, including a pharmacological procedure for the evaluation of iproniazidlike drugs. , 1959, The Journal of pharmacology and experimental therapeutics.

[12]  J. Leysen,et al.  Apomorphine: chemistry, pharmacology, biochemistry. , 1976, International review of neurobiology.

[13]  A. Wauquier.  The influence of psychoactive drugs on brain self-stimulation behaviour , 1976 .

[14]  D. A. Greenberg,et al.  Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain , 1977, Neuropharmacology.

[15]  C J Niemegeers,et al.  The pharmacology of penfluridol (R 16341) a new potent and orally long-acting neuroleptic drug. , 1970, European journal of pharmacology.

[16]  J. Vereecken,et al.  Sleep disorders in patients with severe mental depression: Double‐blind placebo‐controlled evaluation of the value of pipamperone (Dipiperon®) , 1977, Acta psychiatrica Scandinavica.

[17]  A new technique for studying the inhibitory effects of drugs on discriminatory avoidance-escape behaviour in rats , 1962 .