Semen endocannabinoids are correlated to sperm quality in a cohort of 200 young Swiss men

A role for endocannabinoids in the male and female reproductive systems has been highlighted during the recent decades. Some of these compounds bind the cannabinoid CB1 receptor, which is abundantly expressed in the central nervous system but also present in the reproductive system, while others act as ‘entourage compounds’ modulators.

[1]  L. Priskorn,et al.  Semen quality of young men in Switzerland: a nationwide cross‐sectional population‐based study , 2019, Andrology.

[2]  J. Hotaling,et al.  Cannabis and Male Fertility: A Systematic Review. , 2019, The Journal of urology.

[3]  S. Rudaz,et al.  Steroid profiles in both blood serum and seminal plasma are not correlated and do not reflect sperm quality: Study on the male reproductive health of fifty young Swiss men. , 2018, Clinical biochemistry.

[4]  J. Crippa,et al.  A column switching ultrahigh-performance liquid chromatography-tandem mass spectrometry method to determine anandamide and 2-arachidonoylglycerol in plasma samples , 2017, Analytical and Bioanalytical Chemistry.

[5]  A. Agarwal,et al.  Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility , 2015, Journal of Assisted Reproduction and Genetics.

[6]  Mauro Maccarrone,et al.  Endocannabinoids, Related Compounds and Their Metabolic Routes , 2014, Molecules.

[7]  M. Maccarrone,et al.  The role of endocannabinoids in gonadal function and fertility along the evolutionary axis , 2012, Molecular and Cellular Endocrinology.

[8]  T. Toth,et al.  Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. , 2010, Reproductive toxicology.

[9]  A. Ambrosini,et al.  Endocannabinoids and Human Sperm Cells , 2010, Pharmaceuticals.

[10]  A. Meinhardt.  Andrology 3rd edition-E. Nieschlag, H.M. Behre, S. Nieschlag （eds） , 2010 .

[11]  G D Adamson,et al.  International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. , 2009, Fertility and sterility.

[12]  B. Barboni,et al.  Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability. , 2009, Endocrinology.

[13]  K. Verhoeckx,et al.  Development and validation of a quantitative method for the determination of 12 endocannabinoids and related compounds in human plasma using liquid chromatography-tandem mass spectrometry. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[14]  Aurélien Thomas,et al.  Quantitative and qualitative profiling of endocannabinoids in human plasma using a triple quadrupole linear ion trap mass spectrometer with liquid chromatography. , 2009, Rapid communications in mass spectrometry : RCM.

[15]  S. Bell,et al.  The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy. , 2007, Human reproduction update.

[16]  S. Dey,et al.  Jekyll and Hyde : Two Faces of Cannabinoid Signaling in Male and Female Fertility , 2006 .

[17]  E. Bertoli,et al.  Oleoylethanolamide Protects Human Sperm Cells from Oxidation Stress: Studies on Cases of Idiopathic Infertility1 , 2006, Biology of reproduction.

[18]  E. Bertoli,et al.  Idiopathic infertility: effect of palmitoylethanolamide (a homologue of anandamide) on hyperactivated sperm cell motility and Ca2+ influx. , 2005, Journal of andrology.

[19]  D Stewart Irvine,et al.  How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? , 2004, BMJ : British Medical Journal.

[20]  M. Maccarrone,et al.  The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis , 2003, Cell Death and Differentiation.

[21]  D. Piomelli,et al.  N-Acylethanolamines in human reproductive fluids. , 2002, Chemistry and physics of lipids.

[22]  A. Makriyannis,et al.  Evidence that anandamide‐signaling regulates human sperm functions required for fertilization , 2002, Molecular reproduction and development.

[23]  C. Fowler,et al.  The palmitoylethanolamide family: a new class of anti-inflammatory agents? , 2002, Current medicinal chemistry.

[24]  C. Ledent,et al.  The central cannabinoid receptor inactivation suppresses endocrine reproductive functions. , 2001, Biochemical and biophysical research communications.

[25]  H. Hansen,et al.  N-Acylethanolamines and precursor phospholipids - relation to cell injury. , 2000, Chemistry and physics of lipids.

[26]  A. D. Vethaak,et al.  Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation , 2000, Critical reviews in toxicology.

[27]  R. Kolodny,et al.  Depression of plasma testosterone levels after chronic intensive marihuana use. , 1974, The New England journal of medicine.

[28]  Organización Mundial de la Salud.  WHO laboratory manual for the examination and processing of human semen , 2010 .

[29]  A. Bartke,et al.  In vitro effects of psychoactive and non-psychoactive cannabinoids on immature rat Sertoli cell function. , 1993, Life sciences.