论文信息 - A dLight-ful New View of Neuromodulation

A dLight-ful New View of Neuromodulation

Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

Talia N. Lerner | Caitlin V. Cosme | Gates K. Palissery | Talia N. Lerner

[1] S. Cragg,et al. Striatal dopamine neurotransmission: regulation of release and uptake. , 2016, Basal ganglia.

[2] M. Howe,et al. Rapid signaling in distinct dopaminergic axons during locomotion and reward , 2016, Nature.

[3] Anatol C. Kreitzer,et al. A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice , 2018, Cell.

[4] A. Gordus,et al. Sensitive red protein calcium indicators for imaging neural activity , 2016, bioRxiv.

[5] Aaron M. Streets,et al. Ultralarge Modulation of Single Wall Carbon Nanotube Fluorescence Mediated by Neuromodulators Adsorbed on Arrays of Oligonucleotide Rings , 2018, bioRxiv.

[6] Arif Hamid,et al. Forebrain dopamine value signals arise independently from midbrain dopamine cell firing , 2018, bioRxiv.

[7] A. Nimmerjahn,et al. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors , 2018, Science.

[8] Stefan R. Pulver,et al. Independent Optical Excitation of Distinct Neural Populations , 2014, Nature Methods.

[9] Stefan R. Pulver,et al. Ultra-sensitive fluorescent proteins for imaging neuronal activity , 2013, Nature.