Review: Anti-infectives Advances in tetracycline antibiotics

The patent status of tetracycline research for the period of 1991 to 1995 is presented. Topics covered include new tetracyclines with intrinsic antibacterial activity against tetracycline-resistant bacteria or which potentiate the activity of the older tetracyclines, new natural products, new chemical methods, and non-infectious disease uses for tetracyclines.

[1]  Y. Gluzman,et al.  Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines , 1994, Antimicrobial Agents and Chemotherapy.

[2]  S. Tanida,et al.  New naphthacenecarboxamide antibiotics, TAN-1518 A and B, have inhibitory activity against mammalian DNA topoisomerase I. , 1994, The Journal of antibiotics.

[3]  S. Levy,et al.  Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria. , 1994, Journal of medicinal chemistry.

[4]  F. Tally,et al.  Synthesis of novel tetracycline derivatives with substitution at the C-8 position , 1994 .

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[6]  J. S. Wells,et al.  Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity. , 1992, The Journal of antibiotics.

[7]  A. Salyers,et al.  Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance , 1992, Clinical Microbiology Reviews.

[8]  I. Chopra,et al.  Tetracyclines, molecular and clinical aspects. , 1992, The Journal of antimicrobial chemotherapy.

[9]  M. Hatsu,et al.  A new tetracycline antibiotic with antitumor activity. II. The structural elucidation of SF2575. , 1992, The Journal of antibiotics.

[10]  L. Golub,et al.  Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. , 1991, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[11]  J. Waitz,et al.  A novel tetracycline from Actinomadura brunnea. Fermentation, isolation and structure elucidation. , 1987, The Journal of antibiotics.