Transplantation of fetal ventral mesencephalic progenitor cells overexpressing high molecular weight fibroblast growth factor 2 isoforms in 6-hydroxydopamine lesioned rats

[1]  Li-Ru Zhao,et al.  Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism , 2014, Experimental Neurology.

[2]  R. Gibb,et al.  Adult hemiparkinsonian rats do not benefit from tactile stimulation , 2014, Behavioural Brain Research.

[3]  E. Arenas Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. , 2014, Journal of molecular cell biology.

[4]  Y. Li,et al.  Co-Transplantation of GDNF-Overexpressing Neural Stem Cells and Fetal Dopaminergic Neurons Mitigates Motor Symptoms in a Rat Model of Parkinson’s Disease , 2013, PloS one.

[5]  R. Roth,et al.  Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[6]  J. Krauss,et al.  Neuronal firing activity and gene expression changes in the subthalamic nucleus after transplantation of dopamine neurons in hemiparkinsonian rats , 2013, Neurobiology of Disease.

[7]  S. Pluchino,et al.  Uncovering novel actors in astrocyte–neuron crosstalk in Parkinson's disease: the Wnt/β‐catenin signaling cascade as the common final pathway for neuroprotection and self‐repair , 2013, The European journal of neuroscience.

[8]  C. Grothe,et al.  The Colayer Method as an Efficient Way to Genetically Modify Mesencephalic Progenitor Cells Transplanted into 6-OHDA Rat Model of Parkinson's Disease , 2012, Cell transplantation.

[9]  S. Dunnett,et al.  Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates , 2011, Journal of Neuroscience Methods.

[10]  C. Grothe,et al.  FGF-2 Deficiency Does Not Influence FGF Ligand and Receptor Expression during Development of the Nigrostriatal System , 2011, PloS one.

[11]  M. Schumacher,et al.  Wnt/β-Catenin Signaling Is an Essential and Direct Driver of Myelin Gene Expression and Myelinogenesis , 2011, The Journal of Neuroscience.

[12]  Richard J Smeyne,et al.  A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse , 2009, Neuroscience.

[13]  J. Zimmer,et al.  Functional effect of FGF2- and FGF8-expanded ventral mesencephalic precursor cells in a rat model of Parkinson's disease , 2008, Brain Research.

[14]  S. Dunnett,et al.  Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease , 2008, Neuroscience.

[15]  Alain Dagher,et al.  Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years , 2008, Nature Medicine.

[16]  M. Cenci,et al.  Advances in understanding l-DOPA-induced dyskinesia , 2007, Current Opinion in Neurobiology.

[17]  A. Björklund,et al.  The Functional Impact of the Intrastriatal Dopamine Neuron Grafts in Parkinsonian Rats Is Reduced with Advancing Disease , 2007, The Journal of Neuroscience.

[18]  C. Grothe,et al.  The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system , 2007, Brain Research Reviews.

[19]  Esther Lipokatic-Takacs,et al.  Fibroblast Growth Factor (FGF)-2 and FGF Receptor 3 Are Required for the Development of the Substantia Nigra, and FGF-2 Plays a Crucial Role for the Rescue of Dopaminergic Neurons after 6-Hydroxydopamine Lesion , 2007, The Journal of Neuroscience.

[20]  C. Grothe,et al.  Nucleofection Is the Most Efficient Nonviral Transfection Method for Neuronal Stem Cells Derived from Ventral Mesencephali with No Changes in Cell Composition or Dopaminergic Fate , 2006, Stem cells.

[21]  Shinn-Zong Lin,et al.  Bridging Nigrostriatal Pathway with Fibroblast Growth Factor-Primed Peripheral Nerves and Fetal Ventral Mesencephalon Transplant Recuperates from Deficits in Parkinsonian Rats , 2006, Cell transplantation.

[22]  J. Grosskreutz,et al.  Dopaminergic properties and function after grafting of attached neural precursor cultures , 2006, Neurobiology of Disease.

[23]  D. Kirik,et al.  Dissociation between short‐term increased graft survival and long‐term functional improvements in Parkinsonian rats overexpressing glial cell line‐derived neurotrophic factor , 2004, The European journal of neuroscience.

[24]  K. Krieglstein Factors promoting survival of mesencephalic dopaminergic neurons , 2004, Cell and Tissue Research.

[25]  G. Nikkhah,et al.  Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms , 2004, Experimental Neurology.

[26]  P. Claus,et al.  Expression of the fibroblast growth factor-2 isoforms and the FGF receptor 1–4 transcripts in the rat model system of Parkinson's disease , 2004, Neuroscience Letters.

[27]  Vesna Sossi,et al.  A double‐blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease , 2003, Annals of neurology.

[28]  P. Claus,et al.  Differential Intranuclear Localization of Fibroblast Growth Factor-2 Isoforms and Specific Interaction with the Survival of Motoneuron Protein* , 2003, The Journal of Biological Chemistry.

[29]  K. Wolff,et al.  Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells* , 2002, The Journal of Biological Chemistry.

[30]  A. Cools,et al.  Effects of fibroblast growth factor and glial-derived neurotrophic factor on akinesia, F-DOPA uptake and dopamine cells in parkinsonian primates. , 2002, Parkinsonism & related disorders.

[31]  A. Björklund,et al.  Growth and Functional Efficacy of Intrastriatal Nigral Transplants Depend on the Extent of Nigrostriatal Degeneration , 2001, The Journal of Neuroscience.

[32]  J Q Trojanowski,et al.  Transplantation of embryonic dopamine neurons for severe Parkinson's disease. , 2001, The New England journal of medicine.

[33]  C. Grothe,et al.  The high molecular weight fibroblast growth factor-2 isoforms (21,000mol. wt and 23,000mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro , 2000, Neuroscience.

[34]  Jenny Karlsson,et al.  Improving the Survival of Grafted Dopaminergic Neurons: A Review over Current Approaches , 2000, Cell transplantation.

[35]  D. Rifkin,et al.  Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals. , 1999, Molecular biology of the cell.

[36]  C. Olanow,et al.  Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. , 1999, Archives of neurology.

[37]  A. Björklund,et al.  Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts. , 1996, Neuroscience.

[38]  J. Fawcett,et al.  The Time Course of Loss of Dopaminergic Neurons and the Gliotic Reaction Surrounding Grafts of Embryonic Mesencephalon to the Striatum , 1996, Experimental Neurology.

[39]  C. Mytilineou,et al.  Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  K. Beck Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons , 1994, Progress in Neurobiology.

[41]  G. Nikkhah,et al.  A microtransplantation approach for cell suspension grafting in the rat parkinson model: A detailed account of the methodology , 1994, Neuroscience.

[42]  B. Doble,et al.  Over-expression of CUG- or AUG-initiated forms of basic fibroblast growth factor in cardiac myocytes results in similar effects on mitosis and protein synthesis but distinct nuclear morphologies. , 1994, Journal of molecular and cellular cardiology.

[43]  G. Nikkhah,et al.  Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat parkinson model , 1993, Neuroscience.

[44]  J. Fawcett,et al.  Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons—II. Effects on nigral transplantsin vivo , 1993, Neuroscience.

[45]  J. Fawcett,et al.  Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons—i. Effectsin vitro , 1993, Neuroscience.

[46]  I. Tooyama,et al.  High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain , 1992, Brain Research.

[47]  A. Björklund Dopaminergic transplants in experimental parkinsonism: cellular mechanisms of graft-induced functional recovery , 1992, Current Opinion in Neurobiology.

[48]  P. Bédard,et al.  Decrease of behavioral and biochemical denervation supersensitivity of rat striatum by nigral transplants , 1991, Neuroscience.

[49]  Yamamura Ken-ichi,et al.  Efficient selection for high-expression transfectants with a novel eukaryotic vector , 1991 .

[50]  H. Niwa,et al.  Efficient selection for high-expression transfectants with a novel eukaryotic vector. , 1991, Gene.

[51]  T. Hökfelt,et al.  Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Engele,et al.  The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685] , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[53]  G. Yancopoulos,et al.  BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra , 1991, Nature.

[54]  G. Ferrari,et al.  Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture. , 1989, Developmental biology.

[55]  A. Björklund,et al.  Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum , 1987, Trends in Neurosciences.

[56]  A. Bjo¨rklund,et al.  Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival , 1985, Brain Research.

[57]  W. Freed,et al.  Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: Long‐term behavioral, biochemical, and histochemical studies , 1980, Annals of neurology.

[58]  A. Björklund,et al.  Reinnervation of the denervated striatum by substantia nigra transplants: Functional consequences as revealed by pharmacological and sensorimotor testing , 1980, Brain Research.

[59]  U. Ungerstedt,et al.  Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. , 1970, Brain research.

[60]  M. Abercrombie Estimation of nuclear population from microtome sections , 1946, The Anatomical record.

[61]  O. Lindvall,et al.  Clinical observations after neural transplantation in Parkinson's disease. , 2000, Progress in brain research.

[62]  A. Björklund,et al.  Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement. , 2000, Progress in brain research.

[63]  F. Gage,et al.  Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease , 1995, Nature Medicine.

[64]  R. Florkiewicz,et al.  Multiple forms of bFGF: differential nuclear and cell surface localization. , 1991, Growth factors.

[65]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[66]  S B Dunnett,et al.  Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation. , 1983, Acta physiologica Scandinavica. Supplementum.