Comparative Study of the Effectiveness of Ondansetron, Metoclopramide and Low Dose Dexamethasone to Prevent Postoperative Nausea and Vomiting in Females who Undergo Laparoscopic Cholecystectomy

= 32). The patients were assessed for incidence and severity of nausea and vomiting at intervals of 0-1, 1-6, and 6-24 hours after extubation. Results: The incidence of nausea was as follows among patients: 72 (20.8%) in the ondansetron group, 23.6% in the dexamethasone group, 25.0% in the metoclopramide group, and 30.5% in the control group. Vomiting was found in 49 patients with an incidence rate of 8.1%, 16.3%, 36.7% and 38.7%, in ondansetron, dexamethasone and metoclopramid groups, respectively. The highest incidence of the initial nausea symptom occurred at the 1-6 hour interval in all groups (P = 0.034). Only ondansetron (P = 0.005) and dexamethasone (P = 0.019) were effective in preventing nausea at the 0-1 hour interval. The severity of nausea in patients who received dexamethasone was less. Conclusions: Ondansetron was more effective than dexamethasone and metoclopramide in preventing vomiting after laparoscopic cholecystectomy at intervals of 0-1 and 1-6 hours. Ondansetron delayed the interval of the first onset of nausea and vomiting.

[1]  E. Kipnis,et al.  Impact of a prophylactic strategy on the incidence of nausea and vomiting after general surgery. , 2012, Annales francaises d'anesthesie et de reanimation.

[2]  X. Xiong,et al.  Efficacy of ondansetron vs. metoclopramide in prophylaxis of postoperative nausea and vomiting after laparoscopic cholecystectomy: a systematic review and meta-analysis. , 2012, Hepato-gastroenterology.

[3]  Bin Wang,et al.  Effect of prophylactic dexamethasone on nausea and vomiting after laparoscopic gynecological operation: meta-analysis. , 2011, Middle East journal of anaesthesiology.

[4]  C. Hornuss,et al.  Pharmacologic management of postoperative nausea and vomiting , 2011, Expert opinion on pharmacotherapy.

[5]  S. Ho,et al.  Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk. , 2011, Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists.

[6]  S. Kahnamouii,et al.  Comparison of ondansetron and metoclopramide antiemetic prophylaxis in maxillofacial surgery patients. , 2011, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[7]  Subhi M. Alghanem,et al.  Optimization of anesthesia antiemetic measures versus combination therapy using dexamethasone or ondansetron for the prevention of postoperative nausea and vomiting , 2010, Surgical Endoscopy.

[8]  A. Kaki,et al.  Prophylaxis of postoperative nausea and vomiting with ondansetron, metoclopramide, or placebo in total intravenous anesthesia patients undergoing laparoscopic cholecystectomy. , 2008, Saudi medical journal.

[9]  E. Erhan,et al.  Ondansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy , 2008, Surgical Endoscopy.

[10]  A. B. Channa,et al.  Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo. , 1997, Canadian journal of anaesthesia = Journal canadien d'anesthesie.