Fracture prevention by femoroplasty—cement augmentation of the proximal femur

The prevention of hip fractures is a desirable goal to reduce morbidity, mortality, and socio‐economic burden. We evaluated the influence on femoral strength of different clinically applicable cementing techniques as “femoroplasty.” Twenty‐eight human cadaveric femora were augmented by means of four clinically applicable percutaneous cementing techniques and then tested biomechanically against their native contralateral control to determine fracture strength in an established biomechanical model mimicking a fall on the greater trochanter. The energy applied until fracture could be significantly increased by two of the methods by 160% (53.1 Nm vs. 20.4 Nm, p < 0.001) and 164% (47.1 Nm vs. 17.8 Nm, p = 0.008), respectively. The peak load to failure was significantly increased by three of the methods by 23% (3818.3 N vs. 3095.7 N, p = 0.003), 35% (3698.4 N vs. 2737.5 N, p = 0.007), and 12% (3056.8 N vs. 2742.8 N, p = 0.005), respectively. The femora augmented with cemented double drill holes had a lower fracture strength than the single drilled ones. Experimental femoroplasty is a technically feasible procedure for the prophylactic reinforcement of the osteoporotic proximal femur and, hence, could be an auxiliary treatment option to protect the proximal femur against osteoporotic fractures. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1753–1758, 2011

[1]  P. Cripton,et al.  During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures. , 2009, Journal of biomechanics.

[2]  W. C. Hayes,et al.  Effects of loading rate on strength of the proximal femur , 1994, Calcified Tissue International.

[3]  A. Gafni,et al.  Do hip protectors decrease the risk of hip fracture in institutional and community-dwelling elderly? A systematic review and meta-analysis of randomized controlled trials , 2005, Osteoporosis International.

[4]  O Johnell,et al.  The socioeconomic burden of fractures: today and in the 21st century. , 1997, The American journal of medicine.

[5]  H. Barden,et al.  Femur strength index predicts hip fracture independent of bone density and hip axis length , 2005, Osteoporosis International.

[6]  L. Forsén Survival after hip fracture , 2006, Osteoporosis International.

[7]  J A Stevens,et al.  Reducing falls and resulting hip fractures among older women. , 2000, Home care provider.

[8]  Douglas P Kiel,et al.  Second hip fracture in older men and women: the Framingham Study. , 2007, Archives of internal medicine.

[9]  M L Bouxsein,et al.  Effect of local density changes on the failure load of the proximal femur , 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  H K Genant,et al.  Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. , 1990, JAMA.

[11]  Christoph Fankhauser,et al.  Femoroplasty-augmentation of mechanical properties in the osteoporotic proximal femur: a biomechanical investigation of PMMA reinforcement in cadaver bones. , 2004, Clinical biomechanics.

[12]  Stephen M Belkoff,et al.  A Biomechanical Evaluation of Femoroplasty Under Simulated Fall Conditions , 2010, Journal of orthopaedic trauma.

[13]  E. Barrett-Connor,et al.  Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. , 2001, JAMA.

[14]  W C Hayes,et al.  Age-related reductions in the strength of the femur tested in a fall-loading configuration. , 1995, The Journal of bone and joint surgery. American volume.

[15]  W. C. Hayes,et al.  Impact direction from a fall influences the failure load of the proximal femur as much as age-related bone loss , 1996, Calcified Tissue International.

[16]  T. J. van der Steenhoven,et al.  Augmentation with silicone stabilizes proximal femur fractures: an in vitro biomechanical study. , 2009, Clinical biomechanics.

[17]  P. Ell,et al.  Variation between femurs as measured by dual energy X-ray absorptiometry (DEXA) , 2004, European Journal of Nuclear Medicine.

[18]  R. Sulkava,et al.  Incidence of second hip fractures. A population-based study , 2007, Osteoporosis International.

[19]  J. L. Melton,et al.  Perspectives: How many women have osteoporosis now? , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  D. Felsenberg,et al.  Epidemiology, treatment and costs of osteoporosis in Germany—the BoneEVA Study , 2006, Osteoporosis International.

[21]  W C Hayes,et al.  The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. , 1990, The Journal of bone and joint surgery. American volume.

[22]  Eve Donnelly,et al.  The assessment of fracture risk. , 2010, The Journal of bone and joint surgery. American volume.

[23]  S. Cummings,et al.  The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. , 1990, Clinical orthopaedics and related research.

[24]  C Zacker,et al.  An Economic Evaluation of Energy-Absorbing Flooring to Prevent Hip Fractures , 1998, International Journal of Technology Assessment in Health Care.

[25]  M. Maravic,et al.  Incidence and cost of osteoporotic fractures in France during 2001. A methodological approach by the national hospital database , 2005, Osteoporosis International.

[26]  V. Wiwanitkit Is prophylactic fixation a cost-effective method to prevent a future contralateral fragility hip fracture? , 2010, Journal of orthopaedic trauma.

[27]  Harry K. Genant,et al.  Appendicular Bone Density and Age Predict Hip Fracture in Women , 1990 .

[28]  Paul D. Miller,et al.  Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: Results from the national osteoporosis risk assessment , 2002 .

[29]  J. Magaziner,et al.  Hip fracture: Risk factors and outcomes , 2003, Current osteoporosis reports.

[30]  P. Delmas,et al.  Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study , 2005, Osteoporosis International.

[31]  Volker Kuhn,et al.  Reproducibility and Side Differences of Mechanical Tests for Determining the Structural Strength of the Proximal Femur , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  P Kannus,et al.  Prevention of hip fracture in elderly people with use of a hip protector. , 2000, The New England journal of medicine.

[33]  W A Ray,et al.  A randomized trial of a consultation service to reduce falls in nursing homes. , 1997, JAMA.

[34]  S. Cummings,et al.  Bone mineral density and the risk of incident nonspinal fractures in black and white women. , 2005, JAMA.

[35]  S J Ferguson,et al.  Femoroplasty--augmentation of the proximal femur with a composite bone cement--feasibility, biomechanical properties and osteosynthesis potential. , 2007, Medical engineering & physics.

[36]  L. Elffors ARE OSTEOPOROTIC FRACTURES DUE TO OSTEOPOROSIS? IMPACTS OF A FRAILTY PANDEMIC IN AN AGING WORLD , 1998 .