RESEARCH AND DEVELOPMENT ON GLAUCOMA DIAGNOSIS SOFTWARE USING A SEMANTIC DIFFERENTIAL METHOD

The visual field test can be used to examine visual field impairment or diagnose the progression of ophthalmologic diseases such as glaucoma. Visual field impairment is related to optic nerve impairment. The doctor's views of optic nerve impairments are based on optic discs and retinal nerve fiber layers. In this research, we developed glaucoma diagnosis software, applied a semantic differential method, and calculated the glaucoma probability using multivariate analysis. The software is capable of receiving perimetric Humphrey perimeter data. Visual field tests were performed on 7 eyes of 7 patients with glaucoma, and we calculated their glaucoma probability. The fundus photography was performed in 6 eyes of 6 healthy persons. We used the software to measure the number of pixels in an image, and it also calculated their cup/disc ratios, the size and area of the disc and cup, and so on. We surveyed the correlation between glaucoma probability and the Collaborative Initial Glaucoma Treatment Study (CIGTS). The correlation coefficient was 0.881, which shows significant correlation between these two factors. The vertical cup/disc ratio was 0.79±0.04, and the horizontal cup/disc ratio 0.75±0.03. The disc area was 28031±4946, and that of the cup was 16075±2383: the average ±standard deviation. We established a questionnaire dialog using the semantic differential method and adopted scrollbars to the questionnaire dialog to reflect the doctor's delicate meanings.

[1]  Tarow Indow,et al.  Multidimensional mapping of visual space with real and simulated stars , 1968 .

[2]  V. Lee,et al.  Retinal nerve fiber layer measurement by nerve fiber analyzer in normal subjects and patients with glaucoma. , 1999, Ophthalmology.

[3]  A Heijl,et al.  Early Manifest Glaucoma Trial: design and baseline data. , 1999, Ophthalmology.

[4]  S. Tsukahara,et al.  Epidemiology of glaucoma in Japan--a nationwide glaucoma survey. , 1991, Japanese journal of ophthalmology.

[5]  E. Chihara,et al.  Retinal nerve fiber layer defect as an early manifestation of diabetic retinopathy. , 1993, Ophthalmology.

[6]  Lotfi A. Zadeh,et al.  The Concepts of a Linguistic Variable and its Application to Approximate Reasoning , 1975 .

[7]  B. Schwartz,et al.  Cupping and pallor of the optic disc. , 1973, Archives of ophthalmology.

[8]  R. Gliklich,et al.  Visual field change in low-tension glaucoma over a five-year follow-up. , 1989, Ophthalmology.

[9]  A. Kandel,et al.  Fuzzy linear regression and its applications to forecasting in uncertain environment , 1985 .

[10]  Drance Sm,et al.  Sector haemorrhage--a probable acute ischaemic disc change in chronic simple glaucoma. , 1970 .

[11]  C. Osgood,et al.  Factor analysis of meaning. , 1955, Journal of experimental psychology.

[12]  C. Osgood,et al.  The Measurement of Meaning , 1958 .

[13]  A C Viswanathan,et al.  Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma , 1999, The British journal of ophthalmology.

[14]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[15]  S. Asrani,et al.  A new method for rapid mapping of the retinal thickness at the posterior pole. , 1996, Investigative ophthalmology & visual science.

[16]  N. Newman,et al.  The earliest observable defect in glaucoma? , 1972, Lancet.

[17]  Uriel Weinreich,et al.  Travels through semantic space , 1958 .

[18]  R. Luce,et al.  On the possible psychophysical laws. , 1959, Psychological review.

[19]  P. Lichter,et al.  The Collaborative Initial Glaucoma Treatment Study: study design, methods, and baseline characteristics of enrolled patients. , 1999, Ophthalmology.

[20]  R. Webb,et al.  Confocal scanning laser ophthalmoscope. , 1987, Applied optics.

[21]  A. Sommer,et al.  The nerve fiber layer in the diagnosis of glaucoma. , 1977, Archives of ophthalmology.

[22]  J. Fujimoto,et al.  Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography. , 2003, Archives of ophthalmology.

[23]  W. Green,et al.  Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. , 1982, Archives of ophthalmology.

[24]  T. Indow,et al.  Multidimensional mapping of Munsell colors varying in hue and chroma. , 1960, Journal of experimental psychology.

[25]  Don A. Dillman,et al.  Contribution of personalization to mail questionnaire response as an element of a previously tested method. , 1974 .

[26]  C. Osgood.  Studies on the generality of affective meaning systems. , 1962 .

[27]  G Zinser,et al.  Reproducibility of topographic measurements of the optic nerve head with laser tomographic scanning. , 1989, Ophthalmology.