The Continuum of Metadata Quality: Defining, Expressing, Exploiting

9 alpha ,15 alpha -Dihydroxy-11 alpha ,12 alpha -difluoromethylene-prosta-13-trans-enoic acid and 5-cis-13-transdienoic acid, 9-keto-11 alpha ,12 alpha -difluoromethylene-15 alpha -hydroxyprosta-13-trans-enoic acid and 5-cis-13-trans-dienoic acid, the 11 beta ,12 beta -difluoromethylene-12-epi compounds, as well as the pharmaceutically acceptable, non-toxic esters and salts thereof, process for the production of same and intermediates obtained by this process. These compounds possess prostaglandin-like activity and thus are useful in the treatment of mammals, where prostaglandins are indicated.