A review of diabetic retinopathy: Datasets, approaches, evaluation metrics and future trends

Abstract Diabetic Retinopathy (DR) is the condition caused due to uncontrolled diabetes that can lead to vision impairment. It greatly affects the retinal blood vessels and diminishes the fundus light-sensitive inner coating. Early diagnosis and regular screening of this disease are essential for prompt processing through artificial intelligence techniques. This paper targets assessing the latest techniques for screening and diagnosing DR, including 94 articles based on the Detection and grading of DR. For every analyzed approach, tables are summarized detailing imaging procedure used, datasets, performance metrics used. The research gaps are also highlighted in this paper. Despite the consistent progression and methods actualized in this field, a couple of issues actually should be centered on. The noise and contrast of the image in Image enhancement are still in the infancy stage for high resolution. This study covers a review of existing image techniques, the gold standard and private datasets available, performance measures used for detection and grading of DR. Now the future research focuses on the amalgamation of the dataset as well as techniques to make the generalized technique for detecting the lesion in DR through an automated system. Moreover, various research gaps have also been taken into account for further research. This review is beneficial to the researchers working in the field of medical imaging to screen and diagnose diseases.

[1]  Romany F Mansour,et al.  Deep-learning-based automatic computer-aided diagnosis system for diabetic retinopathy , 2017, Biomedical Engineering Letters.

[2]  M. Akiyama,et al.  Microaneurysm Imaging Using Multiple En Face OCT Angiography Image Averaging: Morphology and Visualization. , 2019, Ophthalmology. Retina.

[3]  Hwa Liang Leo,et al.  The 16th International Conference on Biomedical Engineering , 2017 .

[4]  Hossein Rabbani,et al.  Diabetic Retinopathy Grading by Digital Curvelet Transform , 2012, Comput. Math. Methods Medicine.

[5]  Patrick Horain,et al.  Deep CNN frameworks comparison for malaria diagnosis , 2019, ArXiv.

[6]  Nigel M. Bolster,et al.  A review of feature-based retinal image analysis , 2017 .

[7]  Xiyu Liu,et al.  Deep membrane systems for multitask segmentation in diabetic retinopathy , 2019, Knowl. Based Syst..

[8]  Santi P. Maity,et al.  Automatic Detection of Retinal Lesions for Screening of Diabetic Retinopathy , 2018, IEEE Transactions on Biomedical Engineering.

[9]  S. Kumar,et al.  Automated lesion detectors in retinal fundus images , 2015, Comput. Biol. Medicine.

[10]  J. Forrester,et al.  Epidemiology of diabetic retinopathy and macular oedema: a systematic review , 2004, Eye.

[11]  Arunkumar Rajendran,et al.  Multi-retinal disease classification by reduced deep learning features , 2017, Neural Computing and Applications.

[12]  Behzad Aliahmad,et al.  Fundus images analysis using deep features for detection of exudates, hemorrhages and microaneurysms , 2018, BMC Ophthalmology.

[13]  Matthew B. Blaschko,et al.  An ensemble deep learning based approach for red lesion detection in fundus images , 2017, Comput. Methods Programs Biomed..

[14]  Mong-Li Lee,et al.  An effective approach to detect lesions in color retinal images , 2000, Proceedings IEEE Conference on Computer Vision and Pattern Recognition. CVPR 2000 (Cat. No.PR00662).

[15]  Selim Demir,et al.  Detection of hemorrhage in retinal images using linear classifiers and iterative thresholding approaches based on firefly and particle swarm optimization algorithms , 2019, Turkish J. Electr. Eng. Comput. Sci..

[16]  Mona Leeza,et al.  Detection of severity level of diabetic retinopathy using Bag of features model , 2019, IET Comput. Vis..

[17]  S. Tamil Selvi,et al.  A novel automated system of discriminating Microaneurysms in fundus images , 2020, Biomed. Signal Process. Control..

[18]  Malay Kishore Dutta,et al.  A robust zero-watermarking scheme for tele-ophthalmological applications , 2017, J. King Saud Univ. Comput. Inf. Sci..

[19]  Lei Zhang,et al.  Multi-level deep supervised networks for retinal vessel segmentation , 2017, International Journal of Computer Assisted Radiology and Surgery.

[20]  Greg Russell,et al.  DR HAGIS—a fundus image database for the automatic extraction of retinal surface vessels from diabetic patients , 2017, Journal of medical imaging.

[21]  Jaskirat Kaur,et al.  A generalized method for the segmentation of exudates from pathological retinal fundus images , 2018 .

[22]  Yuan Luo,et al.  Automated Diabetic Retinopathy Detection Based on Binocular Siamese-Like Convolutional Neural Network , 2019, IEEE Access.

[23]  Qaisar Abbas,et al.  Automatic recognition of severity level for diagnosis of diabetic retinopathy using deep visual features , 2017, Medical & Biological Engineering & Computing.

[24]  Bart M. ter Haar Romeny,et al.  Retinal Microaneurysms Detection Using Local Convergence Index Features , 2017, IEEE Transactions on Image Processing.

[25]  Muhammad Rafiq Mufti,et al.  Diabetic retinopathy detection and classification using hybrid feature set , 2018, Microscopy research and technique.

[26]  Brian C. Capell,et al.  The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. , 2016, The Journal of investigative dermatology.

[27]  S Sivaprasad,et al.  The unmet need for better risk stratification of non‐proliferative diabetic retinopathy , 2018, Diabetic medicine : a journal of the British Diabetic Association.

[28]  Enrique J. Carmona,et al.  Fast detection of the main anatomical structures in digital retinal images based on intra- and inter-structure relational knowledge , 2017, Comput. Methods Programs Biomed..

[29]  Lin Li,et al.  Microaneurysm Detection Using Principal Component Analysis and Machine Learning Methods , 2018, IEEE Transactions on NanoBioscience.

[30]  Yanjun Peng,et al.  BSCN: bidirectional symmetric cascade network for retinal vessel segmentation , 2020, BMC Medical Imaging.

[31]  Mustafa Mumtaz,et al.  Automatic detection of retinal hemorrhages by exploiting image processing techniques for screening retinal diseases in diabetic patients , 2017, International Journal of Diabetes in Developing Countries.

[32]  Jacques Wainer,et al.  A data-driven approach to referable diabetic retinopathy detection , 2019, Artif. Intell. Medicine.

[33]  Bin Xia,et al.  Feasibility of Diagnosing Both Severity and Features of Diabetic Retinopathy in Fundus Photography , 2019, IEEE Access.

[34]  Rishab Gargeya,et al.  Automated Identification of Diabetic Retinopathy Using Deep Learning. , 2017, Ophthalmology.

[35]  Andreas Holzinger,et al.  Detection of Diabetic Retinopathy and Maculopathy in Eye Fundus Images Using Deep Learning and Image Augmentation , 2019, CD-MAKE.

[36]  Manoranjan Paul,et al.  Computerised approaches for the detection of diabetic retinopathy using retinal fundus images: a survey , 2017, Pattern Analysis and Applications.

[37]  M. Usman Akram,et al.  Automated system for the detection of hypertensive retinopathy , 2014, 2014 4th International Conference on Image Processing Theory, Tools and Applications (IPTA).

[38]  B. Dhillon,et al.  Imaging in Diabetic Retinopathy: A Review of Current and Future Techniques. , 2016, Current diabetes reviews.

[39]  Chandan Chakraborty,et al.  Detection of Hard Exudates in Retinal Fundus Images Using Deep Learning , 2018, 2018 IEEE International Conference on System, Computation, Automation and Networking (ICSCA).

[40]  Kenneth W. Tobin,et al.  Exudate-based diabetic macular edema detection in fundus images using publicly available datasets , 2012, Medical Image Anal..

[41]  Mario Molinara,et al.  A multi-context CNN ensemble for small lesion detection , 2020, Artif. Intell. Medicine.

[42]  Somshubra Majumdar,et al.  Microaneurysm detection using fully convolutional neural networks , 2018, Comput. Methods Programs Biomed..

[43]  Konstantina S. Nikita,et al.  Automatic retinal image registration scheme using global optimization techniques , 1999, IEEE Transactions on Information Technology in Biomedicine.

[44]  B. M. Patre,et al.  A clustering approach for exudates detection in screening of diabetic retinopathy , 2016, 2016 International Conference on Signal and Information Processing (IConSIP).

[45]  David A Mackey,et al.  Current state and future prospects of artificial intelligence in ophthalmology: a review , 2018, Clinical & experimental ophthalmology.

[46]  Rangaraj M. Rangayyan,et al.  Development of a screening tool for staging of diabetic retinopathy in fundus images , 2015, Medical Imaging.

[47]  Subhashini Venugopalan,et al.  Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs. , 2016, JAMA.

[48]  U. Rajendra Acharya,et al.  Computer-aided diagnosis of diabetic retinopathy: A review , 2013, Comput. Biol. Medicine.

[49]  Bin Sheng,et al.  Clinical Report Guided Retinal Microaneurysm Detection With Multi-Sieving Deep Learning , 2018, IEEE Transactions on Medical Imaging.

[50]  F. Arcadu,et al.  Deep learning algorithm predicts diabetic retinopathy progression in individual patients , 2019, npj Digital Medicine.

[51]  J. Oleszczuk,et al.  Advances in retinal imaging modalities: Challenges and opportunities , 2016 .

[52]  T. Bek Fine structure in diabetic retinopathy lesions as observed by adaptive optics imaging. A qualitative study , 2014, Acta ophthalmologica.

[53]  Pascale Massin,et al.  A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina , 2002, IEEE Transactions on Medical Imaging.

[54]  Frans Coenen,et al.  Convolutional Neural Networks for Diabetic Retinopathy , 2016, MIUA.

[55]  Andreas Holzinger,et al.  Fuzzy Image Processing and Deep Learning for Microaneurysms Detection , 2020, AI and ML for Digital Pathology.

[56]  Hamidreza Pourreza,et al.  Microaneurysm detection in fundus images using a two-step convolutional neural network , 2019, BioMedical Engineering OnLine.

[57]  Manoranjan Paul,et al.  Deep Learning Models for Retinal Blood Vessels Segmentation: A Review , 2019, IEEE Access.

[58]  Sven Loncaric,et al.  Detection of exudates in fundus photographs using deep neural networks and anatomical landmark detection fusion , 2016, Comput. Methods Programs Biomed..

[59]  Shahaboddin Shamshirband,et al.  A Deep Learning Ensemble Approach for Diabetic Retinopathy Detection , 2019, IEEE Access.

[60]  Baocai Yin,et al.  IDRiD: Diabetic Retinopathy - Segmentation and Grading Challenge. , 2020, Medical image analysis.

[61]  Farida Cheriet,et al.  Red Lesion Detection Using Dynamic Shape Features for Diabetic Retinopathy Screening , 2016, IEEE Transactions on Medical Imaging.

[62]  Tien Yin Wong,et al.  Deep learning in estimating prevalence and systemic risk factors for diabetic retinopathy: a multi-ethnic study , 2019, npj Digital Medicine.

[63]  Paul W. Fieguth,et al.  A new concordant partial AUC and partial c statistic for imbalanced data in the evaluation of machine learning algorithms , 2020, BMC Medical Informatics and Decision Making.

[64]  Yan Liang,et al.  Deep convolutional neural networks for diabetic retinopathy detection by image classification , 2018, Comput. Electr. Eng..

[65]  A. Witkin,et al.  Imaging in Diabetic Retinopathy , 2015, Middle East African journal of ophthalmology.

[66]  Zhang Yi,et al.  Diagnosis of Diabetic Retinopathy Using Deep Neural Networks , 2019, IEEE Access.

[67]  Georgios Leontidis,et al.  A new unified framework for the early detection of the progression to diabetic retinopathy from fundus images , 2017, Comput. Biol. Medicine.

[68]  R. S. Sabeenian,et al.  Modified Alexnet architecture for classification of diabetic retinopathy images , 2019, Comput. Electr. Eng..

[69]  Pan Lin,et al.  An Effective Approach to Detect Hard Exudates in Color Retinal Image , 2012 .

[70]  Yung-Hui Li,et al.  Computer-Assisted Diagnosis for Diabetic Retinopathy Based on Fundus Images Using Deep Convolutional Neural Network , 2019, Mob. Inf. Syst..

[71]  Junhao Wen,et al.  Automatic Detection of Diabetic Retinopathy: A Review on Datasets, Methods and Evaluation Metrics , 2020, IEEE Access.

[72]  Giri Babu Kande,et al.  Automatic Detection of Microaneurysms and Hemorrhages in Digital Fundus Images , 2010, Journal of Digital Imaging.