Exercise and Type 2 Diabetes

Although physical activity (PA) is a key element in the prevention and management of type 2 diabetes, many with this chronic disease do not become or remain regularly active. High-quality studies establishing the importance of exercise and fitness in diabetes were lacking until recently, but it is now well established that participation in regular PA improves blood glucose control and can prevent or delay type 2 diabetes, along with positively affecting lipids, blood pressure, cardiovascular events, mortality, and quality of life. Structured interventions combining PA and modest weight loss have been shown to lower type 2 diabetes risk by up to 58% in high-risk populations. Most benefits of PA on diabetes management are realized through acute and chronic improvements in insulin action, accomplished with both aerobic and resistance training. The benefits of physical training are discussed, along with recommendations for varying activities, PA-associated blood glucose management, diabetes prevention, gestational diabetes mellitus, and safe and effective practices for PA with diabetes-related complications.

[1]  P. Skerrett,et al.  Physical activity and all-cause mortality: what is the dose-response relation? , 2001, Medicine and science in sports and exercise.

[2]  G. Nichols,et al.  Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients. , 2007, Clinical therapeutics.

[3]  J. Mayer Exercise and weight control. , 1959, Postgraduate medicine.

[4]  J. Shaw,et al.  Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes. , 2008, Diabetes research and clinical practice.

[5]  J. Seeley,et al.  The diabetes network internet-based physical activity intervention: a randomized pilot study. , 2001, Diabetes care.

[6]  R. Eckel,et al.  Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. , 2003, Diabetes care.

[7]  G. Brinkworth,et al.  Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes , 2008, Diabetes, obesity & metabolism.

[8]  Zygimantas Cepaitis,et al.  Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. , 2005, Diabetes.

[9]  M. Pletcher,et al.  Exercise Tolerance Testing To Screen for Coronary Heart Disease: A Systematic Review for the Technical Support for the U.S. Preventive Services Task Force , 2004, Annals of Internal Medicine.

[10]  S. Yeung,et al.  Interventions for preventing lower limb soft-tissue injuries in runners. , 2001, The Cochrane database of systematic reviews.

[11]  A E Jeukendrup,et al.  Glucose kinetics during prolonged exercise in highly trained human subjects: effect of glucose ingestion , 1999, The Journal of physiology.

[12]  R. DeFronzo,et al.  Increased insulin sensitivity and insulin binding to monocytes after physical training. , 1979, The New England journal of medicine.

[13]  G. Dutton,et al.  Relationship between self-efficacy and physical activity among patients with type 2 diabetes , 2009, Journal of Behavioral Medicine.

[14]  P. Ekkekakis,et al.  The Affective Impact of Exercise Intensity That Slightly Exceeds the Preferred Level , 2008, Journal of health psychology.

[15]  R. Paffenbarger,et al.  Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. , 1991, The New England journal of medicine.

[16]  V. Stefanović,et al.  Effects of Aerobic Exercise on Microalbuminuria and Enzymuria in Type 2 Diabetic Patients , 2007, Renal failure.

[17]  Seppo Lehto,et al.  Retinopathy Predicts Cardiovascular Mortality in Type 2 Diabetic Men and Women , 2007, Diabetes Care.

[18]  David M Williams,et al.  Acute Affective Response to a Moderate-intensity Exercise Stimulus Predicts Physical Activity Participation 6 and 12 Months Later. , 2008, Psychology of sport and exercise.

[19]  J. Tu,et al.  Recent trends in cardiovascular complications among men and women with and without diabetes. , 2006, Diabetes care.

[20]  R. Barnard,et al.  Effects of NIDDM on the glucose transport system in human skeletal muscle. , 1991, Diabetes research.

[21]  H. Galbo,et al.  Effect of training on the dose-response relationship for insulin action in men. , 1989, Journal of applied physiology.

[22]  Bryan K. Smith,et al.  American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. , 2009, Medicine and science in sports and exercise.

[23]  D. Swain,et al.  Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. , 2003, Diabetes care.

[24]  G. Zoppini,et al.  Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. , 2006, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[25]  T. Stellingwerff,et al.  Carbohydrate supplementation during prolonged cycling exercise spares muscle glycogen but does not affect intramyocellular lipid use , 2007, Pflügers Archiv: European Journal of Physiology.

[26]  K. Tokuyama,et al.  Effects of endurance training on gene expression of insulin signal transduction pathway. , 1995, Biochemical and biophysical research communications.

[27]  C. Snehalatha,et al.  The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1) , 2006, Diabetologia.

[28]  M. Staten,et al.  Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. , 2009, American journal of physiology. Endocrinology and metabolism.

[29]  R. Wolfe,et al.  Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. , 1993, The American journal of physiology.

[30]  G. Bray,et al.  Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes , 2007, Diabetes Care.

[31]  J. Halter,et al.  Combined infusion of epinephrine and norepinephrine during moderate exercise reproduces the glucoregulatory response of intense exercise. , 2003, Diabetes.

[32]  J. Brun,et al.  Substrate oxidation during exercise: type 2 diabetes is associated with a decrease in lipid oxidation and an earlier shift towards carbohydrate utilization. , 2006, Diabetes & metabolism.

[33]  Deborah F Tate,et al.  Physical activity and weight loss: does prescribing higher physical activity goals improve outcome? , 2003, The American journal of clinical nutrition.

[34]  G. Pacini,et al.  The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. , 2005, Archives of physical medicine and rehabilitation.

[35]  R. Brownson,et al.  Environmental correlates of physical activity among individuals with diabetes in the rural midwest. , 2005, Diabetes care.

[36]  E. Richter,et al.  Increased muscle glucose uptake during contractions: no need for insulin. , 1984, The American journal of physiology.

[37]  Maria A. Fiatarone Singh,et al.  Battling insulin resistance in elderly obese people with type 2 diabetes: bring on the heavy weights. , 2003, Diabetes care.

[38]  G. Morrell,et al.  Comparison of Combined Aerobic and High-Force Eccentric Resistance Exercise With Aerobic Exercise Only for People With Type 2 Diabetes Mellitus , 2008, Physical Therapy.

[39]  N. Ruderman,et al.  Enhanced muscle glucose metabolism after exercise in the rat: the two phases. , 1984, The American journal of physiology.

[40]  R. Shulman,et al.  NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  D. King,et al.  Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. , 1995, Journal of applied physiology.

[42]  D. O'Gorman,et al.  Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes , 2006, Diabetologia.

[43]  F. Dela,et al.  Interaction of sulfonylureas and exercise on glucose homeostasis in type 2 diabetic patients. , 1999, Diabetes care.

[44]  J M Jakicic,et al.  Weight loss treatment influences untreated spouses and the home environment: evidence of a ripple effect , 2008, International Journal of Obesity.

[45]  F. Péronnet,et al.  Table of nonprotein respiratory quotient: an update. , 1991, Canadian journal of sport sciences = Journal canadien des sciences du sport.

[46]  H. Galbo,et al.  Effects of training and detraining on dose-response relationship between glucose and insulin secretion. , 1989, The American journal of physiology.

[47]  F. Giorgino,et al.  Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. , 1995, The Journal of clinical investigation.

[48]  M. Aubertin-Leheudre,et al.  No sustained effect of aerobic or resistance training on insulin sensitivity in nonobese, healthy older women. , 2005, Journal of aging and physical activity.

[49]  V. Basevi Standards of Medical Care in Diabetes—2010 , 2010, Diabetes Care.

[50]  J. Wahren,et al.  Splanchnic regulation of glucose production. , 2007, Annual review of nutrition.

[51]  S. Shott,et al.  The effects of range-of-motion therapy on the plantar pressures of patients with diabetes mellitus. , 2002, Journal of the American Podiatric Medical Association.

[52]  Screening for coronary heart disease: recommendation statement. , 2004, Annals of internal medicine.

[53]  I-Min Lee,et al.  Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. , 2007, Medicine and science in sports and exercise.

[54]  Katrina M Turner,et al.  Patients with Type 2 Diabetes experiences of making multiple lifestyle changes: a qualitative study. , 2009, Patient education and counseling.

[55]  MS G. Caleb Alexander MD,et al.  National Prevalence of Lifestyle Counseling or Referral Among African-Americans and Whites with Diabetes , 2008, Journal of General Internal Medicine.

[56]  K. Khunti,et al.  The role of physical activity in the management of impaired glucose tolerance: a systematic review , 2007, Diabetologia.

[57]  Carmen Castaneda-Sceppa,et al.  Physical activity/exercise and type 2 diabetes. , 2004, Diabetes care.

[58]  P. Heagerty,et al.  Daily weight-bearing activity does not increase the risk of diabetic foot ulcers. , 2003, Medicine and science in sports and exercise.

[59]  D. Eddy,et al.  The metabolic syndrome and cardiovascular risk: implications for clinical practice , 2008, International Journal of Obesity.

[60]  O. Ljungqvist,et al.  AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. , 2001, Diabetes.

[61]  D. Nathan,et al.  Implications of the diabetes prevention program and Look AHEAD clinical trials for lifestyle interventions. , 2008, Journal of the American Dietetic Association.

[62]  Robert Ross,et al.  Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men , 2000, Annals of Internal Medicine.

[63]  Stephen W. Sorensen,et al.  Lifetime risk for diabetes mellitus in the United States. , 2003, JAMA.

[64]  H. Vestergaard,et al.  Pre- and posttranslational upregulation of muscle-specific glycogen synthase in athletes. , 1994, The American journal of physiology.

[65]  A. Baron,et al.  Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles. , 1995, The Journal of clinical endocrinology and metabolism.

[66]  R S Paffenbarger,et al.  Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. , 1995, JAMA.

[67]  W. Kraus,et al.  Effect of the volume and intensity of exercise training on insulin sensitivity. , 2004, Journal of applied physiology.

[68]  Raymond C Browning,et al.  Exploiting Social Networks to Mitigate the Obesity Epidemic , 2009, Obesity.

[69]  B. Zinman,et al.  Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes. , 1981, The American journal of physiology.

[70]  J. Saxton,et al.  Upper- vs lower-limb aerobic exercise rehabilitation in patients with symptomatic peripheral arterial disease: a randomized controlled trial. , 2005, Journal of vascular surgery.

[71]  D. James,et al.  Effects of exercise training on in vivo insulin action in individual tissues of the rat. , 1985, The Journal of clinical investigation.

[72]  D. Armstrong,et al.  Screening techniques to identify people at high risk for diabetic foot ulceration: a prospective multicenter trial. , 2000, Diabetes care.

[73]  Mark G. Kosowski,et al.  Gender-specific care of the patient with diabetes: review and recommendations. , 2006, Gender medicine.

[74]  N. Colabianchi,et al.  A prospective study of cardiorespiratory fitness and risk of type 2 diabetes in women. , 2008, Diabetes care.

[75]  A. Kriska,et al.  Handbook of Exercise in Diabetes , 2004 .

[76]  J. Szewieczek,et al.  Impact of the short-term, intense exercise on postprandial glycemia in type 2 diabetic patients treated with gliclazide. , 2007, Journal of diabetes and its complications.

[77]  L. Sharples,et al.  Cost-effectiveness of functional cardiac testing in the diagnosis and management of coronary artery disease: a randomised controlled trial. The CECaT trial. , 2007, Health technology assessment.

[78]  E. Horton,et al.  Skeletal muscle plasma membrane glucose transport and glucose transporters after exercise. , 1990, Journal of applied physiology.

[79]  R. Robertson,et al.  Effect of Exercise Intensity on Glucose and Insulin Metabolism in Obese Individuals and Obese NIDDM Patients , 1996, Diabetes Care.

[80]  G. Dalsky,et al.  Insulin action and secretion in endurance-trained and untrained humans. , 1987, Journal of applied physiology.

[81]  J. Young,et al.  Exercise intensity and glucose tolerance in trained and nontrained subjects. , 1989, Journal of applied physiology.

[82]  E. Feskens,et al.  Cost-Effectiveness of Lifestyle Modification in Diabetic Patients , 2009, Diabetes Care.

[83]  E. Richter,et al.  Effect of exercise on insulin action in human skeletal muscle. , 1989, Journal of applied physiology.

[84]  J. Simoneau,et al.  Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. , 1994, The Journal of clinical investigation.

[85]  R. Fagard,et al.  Effect of resistance training on resting blood pressure: a meta-analysis of randomized controlled trials , 2005, Journal of hypertension.

[86]  D. Kelley,et al.  Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus. , 1994, Metabolism: clinical and experimental.

[87]  H. Gavras,et al.  Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. , 1987, Metabolism: clinical and experimental.

[88]  J. Soberman,et al.  Prevalence and Predictors of Abnormal Cardiovascular Responses to Exercise Testing Among Individuals With Type 2 Diabetes , 2010, Diabetes Care.

[89]  W. Saris,et al.  Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery , 2006, Diabetologia.

[90]  L. Groop,et al.  Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. , 1989, The Journal of clinical investigation.

[91]  I. Shrier,et al.  Stretching before exercise does not reduce the risk of local muscle injury: a critical review of the clinical and basic science literature. , 1999, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[92]  P. García-Rovés,et al.  Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise. , 2003, American journal of physiology. Endocrinology and metabolism.

[93]  Gimeno Orna Ja,et al.  Microalbuminuria and clinical proteinuria as the main predictive factors of cardiovascular morbidity and mortality in patients with type 2 diabetes , 2003 .

[94]  W. Sacco,et al.  Effect of a brief, regular telephone intervention by paraprofessionals for type 2 diabetes , 2009, Journal of Behavioral Medicine.

[95]  William Hollingworth,et al.  BMC Public Health BioMed Central Study protocol , 2004 .

[96]  J. Levine,et al.  The Role of Free-Living Daily Walking in Human Weight Gain and Obesity , 2008, Diabetes.

[97]  R. Klein,et al.  Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study , 2006, British Journal of Ophthalmology.

[98]  D. Lowenthal,et al.  Resistance Exercise and Physical Performance in Adults Aged 60 to 83 , 2002, Journal of the American Geriatrics Society.

[99]  F. Dela,et al.  Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. , 2004, Diabetes.

[100]  M. Lauer,et al.  Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. , 2003, Diabetes care.

[101]  W. Steffee,et al.  Exercise as an adjunct to weight loss and maintenance in moderately obese subjects. , 1989, The American journal of clinical nutrition.

[102]  P. Ritz,et al.  Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[103]  M. Izquierdo,et al.  Lower muscle strength gains in older men with type 2 diabetes after resistance training. , 2008, Journal of diabetes and its complications.

[104]  Lorraine Avery,et al.  Effects of a tailored lifestyle self-management intervention in patients with type 2 diabetes. , 2004, British journal of health psychology.

[105]  J. Cohen,et al.  Exercise training in individuals with diabetic retinopathy and blindness. , 1989, Archives of physical medicine and rehabilitation.

[106]  J. Zierath,et al.  Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. , 1989, The American journal of physiology.

[107]  H. Vincent,et al.  The Influence of Yoga-Based Programs on Risk Profiles in Adults with Type 2 Diabetes Mellitus: A Systematic Review , 2006, Evidence-based complementary and alternative medicine : eCAM.

[108]  B. Goodpaster,et al.  Exercise training increases intramyocellular lipid and oxidative capacity in older adults. , 2004, American journal of physiology. Endocrinology and metabolism.

[109]  M. Clark,et al.  Interindividual Variation in Posture Allocation: Possible Role in Human Obesity , 2005, Science.

[110]  P. Björntorp,et al.  Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM , 1994, Diabetes Care.

[111]  R. J. Shephard,et al.  Breaks in Sedentary Time: Beneficial associations with metabolic risk , 2010 .

[112]  E. McAuley,et al.  Self‐Efficacy Determinants and Consequences of Physical Activity , 2000, Exercise and sport sciences reviews.

[113]  C. Castaneda,et al.  A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. , 2002, Diabetes care.

[114]  N. Mutrie,et al.  Interventions to promote walking: systematic review , 2007, BMJ : British Medical Journal.

[115]  R. Berria,et al.  Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. , 2004, Metabolism: clinical and experimental.

[116]  Stephen Sutton,et al.  Efficacy of a theory-based behavioural intervention to increase physical activity in an at-risk group in primary care (ProActive UK): a randomised trial , 2008, The Lancet.

[117]  Steven Blair,et al.  Low Cardiorespiratory Fitness and Physical Inactivity as Predictors of Mortality in Men with Type 2 Diabetes , 2000, Annals of Internal Medicine.

[118]  B. Ainsworth,et al.  A randomized trial of an intervention to improve self-care behaviors of African-American women with type 2 diabetes: impact on physical activity. , 2002, Diabetes care.

[119]  C. Tudor-Locke,et al.  Controlled outcome evaluation of the First Step Program: a daily physical activity intervention for individuals with type II diabetes , 2004, International Journal of Obesity.

[120]  T. Izawa,et al.  Effect of insulin on adipocyte lipolysis in exercise-trained rats. , 1993, Journal of applied physiology.

[121]  R. DeFronzo,et al.  Exercise in the treatment of type II diabetes , 1983 .

[122]  G. Dalsky,et al.  Glucose tolerance in young and older athletes and sedentary men. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[123]  K. Min,et al.  The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women , 2010, Korean diabetes journal.

[124]  Barbara E K Klein,et al.  Epidemiology of Proliferative Diabetic Retinopathy , 1992, Diabetes Care.

[125]  J. Wahren,et al.  Splanchnic and muscle metabolism during exercise in NIDDM patients. , 1995, The American journal of physiology.

[126]  E. Richter,et al.  Effect of increased plasma free fatty acid concentrations on muscle metabolism in exercising men. , 1991, Journal of applied physiology.

[127]  J. Kuch,et al.  [Factors influencing cardiac complications in patients with type-2 diabetes mellitus and silent myocardial ischaemia: five-year follow-up]. , 2004, Polskie Archiwum Medycyny Wewnetrznej.

[128]  A. Bauman,et al.  Randomized trial of three strategies to promote physical activity in general practice. , 2009, Preventive medicine.

[129]  M. Ory,et al.  Mexican Americans With Type 2 Diabetes: Perspectives on Definitions, Motivators, and Programs of Physical Activity , 2007, Preventing chronic disease.

[130]  K. Stewart Role of exercise training on cardiovascular disease in persons who have type 2 diabetes and hypertension. , 2004, Cardiology clinics.

[131]  K. Asimakopoulou,et al.  Assessment of the transtheoretical model as used by dietitians in promoting physical activity in people with type 2 diabetes. , 2007, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[132]  N. Graves,et al.  The Logan Healthy Living Program: a cluster randomized trial of a telephone-delivered physical activity and dietary behavior intervention for primary care patients with type 2 diabetes or hypertension from a socially disadvantaged community--rationale, design and recruitment. , 2008, Contemporary clinical trials.

[133]  S. Blair,et al.  Exercise capacity and body composition as predictors of mortality among men with diabetes. , 2004, Diabetes care.

[134]  P. Schrauwen,et al.  Validation of the [1,2‐13C]acetate recovery factor for correction of [U‐13C]palmitate oxidation rates in humans , 1998, The Journal of physiology.

[135]  S. Fraser,et al.  Resistance training improves metabolic health in type 2 diabetes: a systematic review. , 2009, Diabetes research and clinical practice.

[136]  I-Min Lee,et al.  Prospective study of gestational diabetes mellitus risk in relation to maternal recreational physical activity before and during pregnancy. , 2004, American journal of epidemiology.

[137]  L. M. L. Arnal,et al.  Microalbuminuria y proteinuria clínica como principales predictores de morbimortalidad cardiovascular en pacientes con diabetes tipo 2 , 2003 .

[138]  F. Merletti,et al.  Renal damage in patients with Type 2 diabetes: a strong predictor of mortality , 2005, Diabetic medicine : a journal of the British Diabetic Association.

[139]  T. Wadden,et al.  The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It , 2006, Obesity.

[140]  N. Mutrie,et al.  A randomized trial investigating the 12‐month changes in physical activity and health outcomes following a physical activity consultation delivered by a person or in written form in Type 2 diabetes: Time2Act , 2009, Diabetic medicine : a journal of the British Diabetic Association.

[141]  S. Blair,et al.  Associations of Cardiorespiratory Fitness and Obesity With Risks of Impaired Fasting Glucose and Type 2 Diabetes in Men , 2009, Diabetes Care.

[142]  G. Dohm,et al.  Seven days of exercise increase GLUT-4 protein content in human skeletal muscle. , 1995, Journal of applied physiology.

[143]  J. Mourad,et al.  Contrôle tensionnel, facteurs de risque et pronostic cardiovasculaire du patient diabétique: 30 ans de progrès , 2008 .

[144]  J. Manson,et al.  Physical activity and incidence of non-insulin-dependent diabetes mellitus in women , 1991, The Lancet.

[145]  A. King,et al.  Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. , 2007, Medicine and science in sports and exercise.

[146]  Hideo Ayame,et al.  [The Da Qing IGT and Diabetes study]. , 2005, Nihon rinsho. Japanese journal of clinical medicine.

[147]  T. Valle,et al.  Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. , 2001, The New England journal of medicine.

[148]  R. Klein,et al.  Prevalence of Microalbuminuria in Older-Onset Diabetes , 1993, Diabetes Care.

[149]  V. Basevi Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[150]  Frank M. Perna,et al.  The Benefits of Exercise for the Clinically Depressed. , 2004, Primary care companion to the Journal of clinical psychiatry.

[151]  P. Painter,et al.  Low-functioning hemodialysis patients improve with exercise training. , 2000, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[152]  A. Consoli Role of Liver in Pathophysiology of NIDDM , 1992, Diabetes Care.

[153]  J. McNeill,et al.  Quantitative methods for measuring the insulin-regulatable glucose transporter (Glut4). , 1997, Journal of pharmacological and toxicological methods.

[154]  Ronald C Plotnikoff,et al.  International Journal of Behavioral Nutrition and Physical Activity Diabetes Netplay: a Physical Activity Website and Linked Email Counselling Randomized Intervention for Individuals with Type 2 Diabetes , 2022 .

[155]  M. Fiatarone Singh,et al.  Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review , 2009, Diabetes/metabolism research and reviews.

[156]  E Goyder,et al.  A review and critique of modelling in prioritising and designing screening programmes. , 2007, Health technology assessment.

[157]  R. Berria,et al.  Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action. , 2003, Journal of applied physiology.

[158]  J. Glatz,et al.  Modulation of fatty-acid-binding protein content of rat heart and skeletal muscle by endurance training and testosterone treatment , 1992, Pflügers Archiv.

[159]  S. Blair,et al.  Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. , 2005, Archives of internal medicine.

[160]  N. Ruderman,et al.  Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin. , 1982, The Journal of clinical investigation.

[161]  D. Moller,et al.  Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. , 1996, The American journal of physiology.

[162]  J. Parkkari,et al.  Effect of long-term endurance and strength training on metabolic control and arterial elasticity in patients with type 2 diabetes mellitus. , 2009, The American journal of cardiology.

[163]  M. Sclavo [Physical activity and risk for cardiovascular events in diabetic women]. , 2001, Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.

[164]  N. Ruderman,et al.  Studies on the mechanism of improved glucose control during regular exercise in Type 2 (non-insulin-dependent) diabetes , 1984, Diabetologia.

[165]  M. Pfeffer,et al.  AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. , 2006, Circulation.

[166]  M. Müller,et al.  Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis. , 2003, Endocrinology.

[167]  J. A. Gimeno Orna,et al.  [Microalbuminuria and clinical proteinuria as the main predictive factors of cardiovascular morbidity and mortality in patients with type 2 diabetes]. , 2003, Revista clinica espanola.

[168]  G. Dutton,et al.  A tailored print-based physical activity intervention for patients with type 2 diabetes. , 2008, Preventive medicine.

[169]  R. Ross,et al.  Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. , 2004, Obesity research.

[170]  J. Hawley,et al.  Carbohydrate and exercise. , 1999, Current opinion in clinical nutrition and metabolic care.

[171]  P. Low,et al.  The sympathetic nervous system in diabetic neuropathy. A clinical and pathological study. , 1975, Brain : a journal of neurology.

[172]  D. Ewing,et al.  Diabetic Autonomic Neuropathy: Present Insights and Future Prospects , 1986, Diabetes Care.

[173]  H. Lithell,et al.  Physical training as treatment for Type 2 (non-insulin-dependent) diabetes in elderly men. A feasibility study over 2 years , 1987, Diabetologia.

[174]  M. Trovati,et al.  Influence of Physical Training on Blood Glucose Control, Glucose Tolerance, Insulin Secretion, and Insulin Action in Non-insulin-dependent Diabetic Patients , 1984, Diabetes Care.

[175]  M. Staten,et al.  Insulin Resistance in Aging Is Related to Abdominal Obesity , 1993, Diabetes.

[176]  H. Tildesley,et al.  Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. , 2003, Diabetes care.

[177]  D A Schoeller,et al.  How much physical activity is needed to minimize weight gain in previously obese women? , 1997, The American journal of clinical nutrition.

[178]  T. Ishii,et al.  Resistance Training Improves Insulin Sensitivity in NIDDM Subjects Without Altering Maximal Oxygen Uptake , 1998, Diabetes Care.

[179]  W. Tamborlane,et al.  Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes , 2007, Pediatric diabetes.

[180]  N. Mutrie,et al.  Promoting and maintaining physical activity in people with type 2 diabetes. , 2004, American journal of preventive medicine.

[181]  B. Braun,et al.  Effects of insulin resistance on substrate utilization during exercise in overweight women. , 2004, Journal of applied physiology.

[182]  Michael J. Mueller,et al.  Effect of Weight-Bearing Activity on Foot Ulcer Incidence in People With Diabetic Peripheral Neuropathy: Feet First Randomized Controlled Trial , 2008, Physical Therapy.

[183]  Sheri R. Colberg,et al.  Balance Training Reduces Falls Risk in Older Individuals With Type 2 Diabetes , 2010, Diabetes Care.

[184]  J. Holloszy,et al.  Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle. , 1994, The Journal of biological chemistry.

[185]  J. Lavoie,et al.  Increased insulin suppression of plasma free fatty acid concentration in exercise-trained rats. , 1993, Journal of applied physiology.

[186]  L. Egede,et al.  Independent factors associated with major depressive disorder in a national sample of individuals with diabetes. , 2003, Diabetes care.

[187]  Andrew D. Williams,et al.  Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study. , 2010, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[188]  Glen P. Kenny,et al.  Effects of Exercise on Glycemic Control and Body Mass in Type 2 Diabetes Mellitus: A Meta-analysis of Controlled Clinical Trials , 2001 .

[189]  K. Borch-Johnsen,et al.  Albuminuria reflects widespread vascular damage , 1989, Diabetologia.

[190]  A. Vinik,et al.  Effects of 8 weeks of flexibility and resistance training in older adults with type 2 diabetes. , 2004, Diabetes care.

[191]  U. Plöckinger,et al.  Risk of exercise-induced hypoglycaemia in patients with type 2 diabetes on intensive insulin therapy: comparison of insulin glargine with NPH insulin as basal insulin supplement. , 2008, Diabetes research and clinical practice.

[192]  Tracey D. Matthews,et al.  Influence Of Body Fat Percentage On Agility, Strength, And Endurance Performance: 2784 , 2009 .

[193]  R. Hoogenveen,et al.  Lifestyle Interventions Are Cost-Effective in People With Different Levels of Diabetes Risk , 2007, Diabetes Care.

[194]  T. Ferro,et al.  Disappearance of microalbuminuria in a patient with type 2 diabetes and the metabolic syndrome in the setting of an intense exercise and dietary program with sustained weight reduction. , 2004, Diabetes care.

[195]  H. Huikuri,et al.  Exercise training improves baroreflex sensitivity in type 2 diabetes. , 2003, Diabetes.

[196]  E. Richter,et al.  Increased Muscle Glucose Uptake After Exercise: No Need for Insulin During Exercise , 1985, Diabetes.

[197]  Martyn Standage,et al.  The effects of exercise interventions on quality of life in clinical and healthy populations; a meta-analysis. , 2009, Social science & medicine.

[198]  I‐Min Lee,et al.  A case-control study of maternal recreational physical activity and risk of gestational diabetes mellitus. , 2004, Diabetes research and clinical practice.

[199]  G. Brooks,et al.  Evaluation of exercise and training on muscle lipid metabolism. , 1999, American journal of physiology. Endocrinology and metabolism.

[200]  David M Williams Exercise, affect, and adherence: an integrated model and a case for self-paced exercise. , 2008, Journal of sport & exercise psychology.

[201]  J. Shaw,et al.  High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. , 2002, Diabetes care.

[202]  L. Spriet,et al.  Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man , 2002, The Journal of physiology.

[203]  J. Mourad,et al.  Blood pressure control, risk factors and cardiovascular prognosis in patients with diabetes: 30 years of progress. , 2008, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[204]  F. Leonetti,et al.  Exercise training can modify the natural history of diabetic peripheral neuropathy. , 2005, Journal of diabetes and its complications.

[205]  W. Garvey,et al.  New insights into the metabolic regulation of insulin action and insulin resistance: role of glucose and amino acids , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[206]  G. Kelley,et al.  Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. , 2007, Public health.

[207]  J A Romijn,et al.  Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. , 1993, The American journal of physiology.

[208]  S. Fowler,et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. , 2002 .

[209]  L. Goodyear,et al.  Exercise, glucose transport, and insulin sensitivity. , 1998, Annual review of medicine.

[210]  W. Kraus,et al.  Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation. , 2009, Journal of applied physiology.

[211]  Oluf Pedersen,et al.  Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. , 2003, The New England journal of medicine.

[212]  Ying Zhang,et al.  Effects of 14-week Tai Ji Quan exercise on metabolic control in women with type 2 diabetes. , 2008, The American journal of Chinese medicine.

[213]  M. Palacín,et al.  The insulin-sensitive GLUT4 storage compartment is a postendocytic and heterogeneous population recruited by acute exercise. , 2001, Biochemical and biophysical research communications.

[214]  J. Lindström,et al.  Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study , 2006, The Lancet.

[215]  J. Blumenthal,et al.  Cardiac rehabilitation as secondary prevention. Agency for Health Care Policy and Research and National Heart, Lung, and Blood Institute. , 1995, Clinical practice guideline. Quick reference guide for clinicians.

[216]  J. Brun,et al.  Fuel oxidation during exercise in middle-aged men: role of training and glucose disposal. , 2002, Medicine and science in sports and exercise.

[217]  E. Amsterdam,et al.  Effects of high resistance training in coronary artery disease. , 1989, The American journal of cardiology.

[218]  J. Singleton,et al.  Impaired Glucose Tolerance and Neuropathy , 2008, The neurologist.

[219]  E. Morrison,et al.  Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes , 2008, BMC complementary and alternative medicine.

[220]  David M Nathan,et al.  Psychological predictors of physical activity in the diabetes prevention program. , 2006, Journal of the American Dietetic Association.

[221]  M. Boulvain,et al.  Exercise for diabetic pregnant women. , 2006, The Cochrane database of systematic reviews.

[222]  R. Shephard Interventions to promote walking: systematic review , 2008 .

[223]  A. Kanagasabapathy,et al.  Rate of Progression of Albuminuria in Type II Diabetes: Five-year prospective study from South India , 1994, Diabetes Care.

[224]  G. Kelley,et al.  Aerobic exercise and resting blood pressure in older adults: a meta-analytic review of randomized controlled trials. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[225]  B. Goodpaster,et al.  Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. , 2003, Diabetes.

[226]  Thomas Reinhold,et al.  Long-term effectiveness of interventions promoting physical activity: a systematic review. , 2008, Preventive medicine.

[227]  A. Rissanen,et al.  How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement , 2003, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[228]  R. Dishman,et al.  Activity Wheel Running Reduces Escape Latency and Alters Brain Monoamine Levels After Footshock , 1997, Brain Research Bulletin.

[229]  K. Kelley,et al.  Aerobic exercise and resting blood pressure: a meta-analytic review of randomized, controlled trials. , 2001, Preventive cardiology.

[230]  Bo Zhang,et al.  The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study , 2008, The Lancet.

[231]  P. Björntorp,et al.  Muscle tissue in obesity with different distribution of adipose tissue. Effects of physical training. , 1986, International journal of obesity.

[232]  H. Galbo,et al.  Responses to acute exercise in type 2 diabetes, with an emphasis on metabolism and interaction with oral hypoglycemic agents and food intake. , 2007, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[233]  N. Ruderman,et al.  Ten-Year Experience with an Exercise-Based Outpatient Life-Style Modification Program in the Treatment of Diabetes Mellitus , 1992, Diabetes Care.

[234]  R. Pate,et al.  Does physical activity during pregnancy reduce the risk of gestational diabetes among previously inactive women? , 2008, Birth.

[235]  M. Pencina,et al.  Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study , 2008, Diabetes Care.

[236]  H. Galbo,et al.  Effect of physical exercise on sensitivity and responsiveness to insulin in humans. , 1988, The American journal of physiology.

[237]  P. Thompson,et al.  Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise. , 1996, Journal of applied physiology.

[238]  R P Tonino,et al.  Effect of physical training on the insulin resistance of aging. , 1989, The American journal of physiology.

[239]  E. Coyle,et al.  Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[240]  M Peyrot,et al.  The Impact of Barriers and Self-Efficacy on Self-Care Behaviors in Type 2 Diabetes , 2001, The Diabetes educator.

[241]  B. Saltin,et al.  Free fatty acids and exercise. , 1993, The American journal of clinical nutrition.

[242]  G A Colditz,et al.  Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. , 1999, JAMA.

[243]  R. Sigal,et al.  Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus , 2003, Diabetologia.

[244]  P. Whelton,et al.  The Prevalence of Nontraditional Risk Factors for Coronary Heart Disease in Patients with Chronic Kidney Disease , 2004, Annals of Internal Medicine.

[245]  P. Painter,et al.  Physical functioning and health-related quality-of-life changes with exercise training in hemodialysis patients. , 2000, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[246]  J. Manson,et al.  Physical activity and gestational diabetes mellitus among Hispanic women. , 2008, Journal of women's health.

[247]  M. White,et al.  Participants' perspective on maintaining behaviour change: a qualitative study within the European Diabetes Prevention Study , 2008, BMC public health.

[248]  Luigi Ferrucci,et al.  Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial. , 2009, JAMA.

[249]  C. Bouchard,et al.  Impact of exercise intensity on body fatness and skeletal muscle metabolism. , 1994, Metabolism: clinical and experimental.

[250]  S. Kivelä,et al.  The effects of physical exercise on depressive symptoms among the aged: a systematic review , 2006, International journal of geriatric psychiatry.

[251]  Jing Wang Effects of Tai Chi exercise on patients with type 2 diabetes. , 2008, Medicine and sport science.

[252]  A. Nicolucci,et al.  Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). , 2010, Archives of internal medicine.

[253]  R. Giorgino,et al.  Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity , 1997, European journal of clinical investigation.

[254]  E. Richter,et al.  Exercise-induced increase in glucose transport, GLUT-4, and VAMP-2 in plasma membrane from human muscle. , 1996, The American journal of physiology.

[255]  A. Kriska,et al.  American College of Sports Medicine position stand. Exercise and type 2 diabetes. , 2000, Medicine and science in sports and exercise.

[256]  J. Shaw,et al.  Objectively Measured Sedentary Time, Physical Activity, and Metabolic Risk , 2007, Diabetes Care.

[257]  M. Cerqueira,et al.  Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. , 1990, The American journal of physiology.

[258]  M. Mueckler,et al.  Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. , 1993, The Journal of biological chemistry.

[259]  J. Kampert,et al.  The Association between Cardiorespiratory Fitness and Impaired Fasting Glucose and Type 2 Diabetes Mellitus in Men , 1999, Annals of Internal Medicine.

[260]  Glen P. Kenny,et al.  Physical Activity/Exercise and Type 2 Diabetes , 2006, Diabetes Care.

[261]  R. Barnard,et al.  The Effects of an Intensive Diet and Exercise Program on Patients With Non-Insulin-Dependent Diabetes Mellitus and Hypertension , 1992 .

[262]  D. Panagiotakos,et al.  Exercise Capacity and All-Cause Mortality in African American and Caucasian Men With Type 2 Diabetes , 2009, Diabetes Care.

[263]  L. Groop,et al.  Contribution of muscle and liver to glucose-fatty acid cycle in humans. , 1993, The American journal of physiology.

[264]  H. Vestergaard,et al.  GLUT-4 content in plasma membrane of muscle from patients with non-insulin-dependent diabetes mellitus. , 1993, The American journal of physiology.

[265]  D. Schuster,et al.  Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. , 2008, The Journal of clinical endocrinology and metabolism.

[266]  James P. Boyle,et al.  Impact of Recent Increase in Incidence on Future Diabetes Burden , 2006, Diabetes Care.

[267]  K. Chad,et al.  Preventing NIDDM among aboriginal people: is exercise the answer? Description of a pilot project using exercise to prevent gestational diabetes. , 1998, International journal of circumpolar health.

[268]  N. Christakis,et al.  The Spread of Obesity in a Large Social Network Over 32 Years , 2007, The New England journal of medicine.

[269]  Will G. Hopkins,et al.  Effects of Different Modes of Exercise Training on Glucose Control and Risk Factors for Complications in Type 2 Diabetic Patients: a Meta-Analysis , 2007, Diabetes Care.

[270]  D. Williamson,et al.  Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. , 2009, Archives of internal medicine.

[271]  Alison Kirk,et al.  Effects of a 12-month physical activity counselling intervention on glycaemic control and on the status of cardiovascular risk factors in people with Type 2 diabetes , 2004, Diabetologia.

[272]  Bo Fernhall,et al.  Endurance training improves post-exercise cardiac autonomic modulation in obese women with and without type 2 diabetes , 2007, European Journal of Applied Physiology.

[273]  A. Tremblay,et al.  Prior meal enhances the plasma glucose lowering effect of exercise in type 2 diabetes. , 2001, Medicine and science in sports and exercise.

[274]  Maria A. Fiatarone Singh,et al.  Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial. , 2008, Age and ageing.

[275]  J. Szewieczek,et al.  Normal insulin response to short-term intense exercise is abolished in Type 2 diabetic patients treated with gliclazide. , 2009, Journal of diabetes and its complications.

[276]  S. Coccheri Approaches to Prevention of Cardiovascular Complications and Events in Diabetes Mellitus , 2012, Drugs.

[277]  P. Björntorp,et al.  The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and Type 2 (non-insulin-dependent) diabetes mellitus , 1985, Diabetologia.

[278]  P. Swan,et al.  Effects of Intensity and Volume on Insulin Sensitivity During Acute Bouts of Resistance Training , 2010, Journal of strength and conditioning research.

[279]  L. Nolte,et al.  Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise. , 1998, Journal of applied physiology.

[280]  B. Howard,et al.  Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes Study , 1997, Diabetes Care.

[281]  L. Stehno-Bittel,et al.  Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes , 2009, Diabetology & metabolic syndrome.

[282]  R. Dyck,et al.  A comparison of rates, risk factors, and outcomes of gestational diabetes between aboriginal and non-aboriginal women in the Saskatoon health district. , 2002, Diabetes care.

[283]  T. Ohkuwa,et al.  Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. , 1990, The American journal of physiology.

[284]  E. Feldman,et al.  Microvascular complications of impaired glucose tolerance. , 2003, Diabetes.

[285]  U. Goldbourt,et al.  High blood pressure and diabetes mellitus: are all antihypertensive drugs created equal? , 2000, Archives of Internal Medicine.

[286]  I. Olkin,et al.  Using pedometers to increase physical activity and improve health: a systematic review. , 2007, JAMA.

[287]  M. Røder,et al.  Enzyme immunoassay for intact human insulin in serum or plasma. , 1993, Clinical chemistry.

[288]  R. Stevens,et al.  UKPDS 60: Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine , 2002, Stroke.

[289]  J. Shaw,et al.  Home-based resistance training is not sufficient to maintain improved glycemic control following supervised training in older individuals with type 2 diabetes. , 2005, Diabetes care.

[290]  A. Wagenmakers,et al.  Substrate utilization in non-obese Type II diabetic patients at rest and during exercise. , 2002, Clinical science.

[291]  T. Valle,et al.  Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland Study design and 1-year interim report on the feasibility of the lifestyle intervention programme , 1999, Diabetologia.

[292]  A. Klip,et al.  Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM , 1996, Diabetologia.

[293]  F. Dela,et al.  The effect of intense exercise on postprandial glucose homeostasis in Type II diabetic patients , 1999, Diabetologia.

[294]  N. Zwar,et al.  Improving glycaemic and BP control in type 2 diabetes. The effectiveness of tai chi. , 2008, Australian family physician.

[295]  P. Ridker,et al.  Polymorphisms in the Advanced Glycosylation End Product–Specific Receptor Gene and Risk of Incident Myocardial Infarction or Ischemic Stroke , 2006, Stroke.

[296]  A. Scheen,et al.  Assessment of insulin resistance in vivo: application to the study of type 2 diabetes. , 1992, Hormone research.

[297]  M. Kohzuki,et al.  Combination of exercise and losartan enhances renoprotective and peripheral effects in spontaneously type 2 diabetes mellitus rats with nephropathy , 2008, Journal of hypertension.

[298]  R. Robertson,et al.  Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM. , 1999, Medicine and science in sports and exercise.

[299]  E. Amsterdam,et al.  Physiologic responses to weight lifting in coronary artery disease. , 1993, The American journal of cardiology.

[300]  Ruth M. Franklin,et al.  Effect of a single vs multiple bouts of exercise on glucose control in women with type 2 diabetes. , 2005, Metabolism: clinical and experimental.

[301]  J. George,et al.  Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss , 2009, Hepatology.

[302]  B. Hurley,et al.  Endurance training in older men and women. I. Cardiovascular responses to exercise. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[303]  U. P. S. T. Force Screening for Coronary Heart Disease: Recommendation Statement , 2004, Annals of Internal Medicine.

[304]  D. Warburton,et al.  Characteristics of Physical Activity Guidelines and their Effect on Adherence , 2009, Sports medicine.

[305]  A. Marette,et al.  Exercise induces the translocation of GLUT4 to transverse tubules from an intracellular pool in rat skeletal muscle. , 1996, Biochemical and biophysical research communications.

[306]  Alanna Kulchak Rahm,et al.  Randomized effectiveness trial of a computer-assisted intervention to improve diabetes care. , 2005, Diabetes care.

[307]  N. Kretchmer,et al.  Effects of exercise intensity on insulin sensitivity in women with non-insulin-dependent diabetes mellitus. , 1995, Journal of applied physiology.

[308]  C. Bouchard,et al.  Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. , 2005, Diabetes care.

[309]  E. Kang,et al.  Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus. , 2006, Metabolism: clinical and experimental.

[310]  K. Khunti,et al.  Rationale, design and baseline data from the Pre-diabetes Risk Education and Physical Activity Recommendation and Encouragement (PREPARE) programme study: a randomized controlled trial. , 2008, Patient education and counseling.

[311]  H. Wyatt,et al.  Are health care professionals advising patients with diabetes or at risk for developing diabetes to exercise more? , 2006, Diabetes care.

[312]  E. Horton,et al.  Glucose transporter number, activity, and isoform content in plasma membranes of red and white skeletal muscle. , 1991, The American journal of physiology.

[313]  J. Ivy,et al.  Persistent increase in glucose uptake by rat skeletal muscle following exercise. , 1981, The American journal of physiology.

[314]  F. Hu,et al.  Physical Activity of Moderate Intensity and Risk of Type 2 Diabetes , 2007, Diabetes Care.

[315]  M. Aubertin-Leheudre,et al.  Aerobic training improves insulin sensitivity 72–120 h after the last exercise session in younger but not in older women , 2005, European Journal of Applied Physiology.

[316]  D. Green,et al.  Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes. , 2002, Diabetes research and clinical practice.

[317]  G. Kelley,et al.  Progressive resistance exercise and resting blood pressure : A meta-analysis of randomized controlled trials. , 2000, Hypertension.

[318]  G. Hunter,et al.  Free-living activity energy expenditure in women successful and unsuccessful at maintaining a normal body weight. , 2002, The American journal of clinical nutrition.

[319]  M. Khazaei,et al.  Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. , 2009, American journal of physiology. Renal physiology.

[320]  J. Halter,et al.  Glucoregulation during and after intense exercise: effects of beta-blockade. , 1994, The Journal of clinical endocrinology and metabolism.

[321]  E. Horton,et al.  Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. , 1992, The Journal of clinical investigation.

[322]  M. Vranic,et al.  Intense exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes. , 2002, Diabetes.

[323]  Exercise during pregnancy and the postpartum period , 1994, Clinical obstetrics and gynecology.

[324]  D. Perrea,et al.  The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus , 2007, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[325]  J. McGavock,et al.  Physical activity for the prevention and management of youth-onset type 2 diabetes mellitus: focus on cardiovascular complications , 2007, Diabetes & vascular disease research.

[326]  F. Liebold,et al.  Diminished insulin response in highly trained athletes. , 1978, Metabolism: clinical and experimental.

[327]  B. Marcus,et al.  Effect of exercise duration and intensity on weight loss in overweight, sedentary women: a randomized trial. , 2003, JAMA.

[328]  J. Simoneau,et al.  Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. , 1997, Journal of applied physiology.

[329]  C. Graham,et al.  Exercise Options for Persons With Diabetic Complications , 1990, The Diabetes educator.

[330]  A. Vinik,et al.  Decreased Exercise Heart Rate and Blood Pressure Response in Diabetic Subjects With Cardiac Autonomic Neuropathy , 1986, Diabetes Care.

[331]  R. Holman,et al.  The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56). , 2001, Clinical science.

[332]  K. Jacobs,et al.  Regulation of blood glucose homeostasis during prolonged exercise. , 2007, Molecules and cells.

[333]  E. Barrett,et al.  Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. , 2009, JAMA.

[334]  A. Vinik,et al.  Diabetic Cardiovascular Autonomic Neuropathy , 2007, Circulation.

[335]  C. Bogardus,et al.  Multiple disturbances of free fatty acid metabolism in noninsulin-dependent diabetes. Effect of oral hypoglycemic therapy. , 1985, The Journal of clinical investigation.

[336]  E. Horton,et al.  Contractile activity increases plasma membrane glucose transporters in absence of insulin. , 1990, The American journal of physiology.

[337]  B. Hurley,et al.  Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. , 1984, JAMA.

[338]  JoAnn Gleeson-Kreig Social Support and Physical Activity in Type 2 Diabetes A Social-Ecologic Approach , 2008, The Diabetes educator.

[339]  C. Vella,et al.  Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. , 2006, Metabolism: clinical and experimental.

[340]  N. Ruderman,et al.  The health professional's guide to diabetes and exercise , 1995 .

[341]  M. Izquierdo,et al.  Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. , 2005, Diabetes care.

[342]  Lippincott Williams Wilkins,et al.  National High Blood Pressure Education Program Working Group Report on Hypertension in Diabetes , 1994, Hypertension.

[343]  T. Rönnemaa,et al.  Effects of long-term physical exercise on serum lipids, lipoproteins and lipid metabolizing enzymes in type 2 (non-insulin-dependent) diabetic patients. , 1988, Diabetes research.

[344]  K. Kosaka,et al.  Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males. , 2005, Diabetes research and clinical practice.

[345]  J. Rosenstock,et al.  Repaglinide versus nateglinide monotherapy: a randomized, multicenter study. , 2004, Diabetes care.

[346]  Simon C Watkins,et al.  The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. , 1996, The Journal of clinical investigation.

[347]  E. Reimann,et al.  Glycogen synthase activation in human skeletal muscle: effects of diet and exercise. , 1979, The American journal of physiology.

[348]  R S Paffenbarger,et al.  The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. , 1993, The New England journal of medicine.

[349]  F. A. Gries,et al.  The Epidemiology of Diabetic Neuropathy , 1993 .

[350]  E. Evans,et al.  Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds. , 2005, Journal of applied physiology.

[351]  M. Spüler,et al.  The epidemiology of diabetic neuropathy. Diabetic Cardiovascular Autonomic Neuropathy Multicenter Study Group. , 1992, Journal of diabetes and its complications.

[352]  J. Manson,et al.  A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus. , 2006, Archives of internal medicine.

[353]  G A Naughton,et al.  Exercise for type 2 diabetes mellitus. , 2006, The Cochrane database of systematic reviews.

[354]  A Schabmann,et al.  Effects of physical training on heart rate variability in diabetic patients with various degrees of cardiovascular autonomic neuropathy. , 1997, Cardiovascular research.

[355]  E. Horton,et al.  Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. , 1999, Diabetes.

[356]  J. Ivy,et al.  Regulation of GLUT4 protein and glycogen synthase during muscle glycogen synthesis after exercise. , 1998, Acta physiologica Scandinavica.

[357]  Jenny S. Radesky,et al.  Associations of Physical Activity and Inactivity Before and During Pregnancy With Glucose Tolerance , 2006, Obstetrics and gynecology.

[358]  R. Holly,et al.  Response of Non-insulin-dependent Diabetic Patients to an Intensive Program of Diet and Exercise , 1982, Diabetes Care.

[359]  E. Carmeli,et al.  Effects of Low-Intensity Exercise on Patients with Peripheral Artery Disease , 2009, The Physician and sportsmedicine.

[360]  R. DeFronzo,et al.  The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man. , 1980, Metabolism: clinical and experimental.

[361]  A. Bigard,et al.  Mobilization of Visceral Adipose Tissue Related to the Improvement in Insulin Sensitivity in Response to Physical Training in NIDDM: Effects of branched-chain amino acid supplements , 1997, Diabetes Care.

[362]  K. Mandroukas,et al.  Heart rate variability modifications following exercise training in type 2 diabetic patients with definite cardiac autonomic neuropathy , 2007, British Journal of Sports Medicine.

[363]  B. Saltin,et al.  Physical Training and Glucose Tolerance in Middle-aged Men with Chemical Diabetes , 1979, Diabetes.

[364]  K. Lie,et al.  Safety and efficacy of beta-blockers in the treatment of stable angina pectoris. , 1990, Journal of cardiovascular pharmacology.

[365]  J. Durnin,et al.  Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years , 1974, British Journal of Nutrition.

[366]  P. Felig,et al.  Splanchnic glucose and muscle glycogen metabolism after glucose feeding during postexercise recovery. , 1978, The American journal of physiology.

[367]  M. Pfeffer,et al.  AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the National Heart, Lung, and Blood Institute. , 2006, Journal of the American College of Cardiology.

[368]  J. Cohen,et al.  Cardiovascular Conditioning in Individuals With Diabetic Retinopathy , 1989, Diabetes Care.