Reply to '‘What’, ‘where’ and ‘how’ in auditory cortex'

ventral pathway is responsible for identifying the speaker. Similarly, the dorsal pathway processes the melody of an instrumental piece, while the ventral pathway recognizes the instrument by its timbre. This ‘What/How’ model of functional segregation requires experimental confirmation. In particular, it will be important to understand how such functional segregation interacts with hemispheric lateralization, a feature of the auditory cortex that characterizes the human brain.

[1]  Richard S. J. Frackowiak,et al.  Right parietal cortex is involved in the perception of sound movement in humans , 1998, Nature Neuroscience.

[2]  R. Meuli,et al.  Auditory agnosia and auditory spatial deficits following left hemispheric lesions: evidence for distinct processing pathways , 2000, Neuropsychologia.

[3]  E. Vaadia,et al.  Unit study of monkey frontal cortex: active localization of auditory and of visual stimuli. , 1986, Journal of neurophysiology.

[4]  Yale E Cohen,et al.  Who Goes There? , 1999, Neuron.

[5]  J. Rauschecker Cortical processing of complex sounds , 1998, Current Opinion in Neurobiology.

[6]  J. Rauschecker Parallel Processing in the Auditory Cortex of Primates , 1998, Audiology and Neurotology.

[7]  D. M. Green,et al.  A panoramic code for sound location by cortical neurons. , 1994, Science.

[8]  P. Goldman-Rakic The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[9]  G H Recanzone,et al.  Correlation between the activity of single auditory cortical neurons and sound-localization behavior in the macaque monkey. , 2000, Journal of neurophysiology.

[10]  M. Mishkin,et al.  Dual streams of auditory afferents target multiple domains in the primate prefrontal cortex , 1999, Nature Neuroscience.

[11]  Terrence R. Stanford,et al.  A neuronal population code for sound localization , 1997, Nature.

[12]  Alan C. Evans,et al.  Lateralization of phonetic and pitch discrimination in speech processing. , 1992, Science.

[13]  R. Zatorre,et al.  Voice-selective areas in human auditory cortex , 2000, Nature.

[14]  C. Wernicke Der aphasische Symptomenkomplex , 1974 .

[15]  Jon H. Kaas,et al.  'What' and 'where' processing in auditory cortex , 1999, Nature Neuroscience.

[16]  J. Rauschecker,et al.  Modality-specific frontal and parietal areas for auditory and visual spatial localization in humans , 1999, Nature Neuroscience.

[17]  M. Mishkin,et al.  Serial and parallel processing in rhesus monkey auditory cortex , 1997, The Journal of comparative neurology.

[18]  Michael S. Brainard,et al.  Neural substrates of sound localization , 1994, Current Opinion in Neurobiology.