Abstract Biomaterials play a key role in most approaches for engineering tissues as substitutes for functional replacement, for components of devices related to therapy and diagnosis, for drug delivery systems and supportive scaffolds for guided tissue growth. Modern biomaterials could be composed of various components, e.g. metals, ceramics, natural tissues, polymers. In this last group, the hydrogels, hydrophilic polymeric gels with requested biocompatibility and designed interaction with living surrounding seem to be one of the most promising group of biomaterials. Especially, if they are formed by means of ionizing radiation. In early 1950s, the pioneers of the radiation chemistry of polymers began some experiments with radiation crosslinking of hydrophilic polymers. However, hydrogels were analyzed mainly from the point of view of the phenomenon associated with radiation synthesis, with topology of network and relation between radiation parameters of the processes. Fundamental monographs on radiation polymer physics and chemistry written by A. Charlesby (Atomic Radition and polymers, Pergamon Press, Oxford, 1960) and A. Chapiro (Radiation Chemistry of Polymeric Systems, Interscience, New York, 1962) proceed from this time. The noticeable interest in the application of radiation techniques to obtain hydrogels for biomedical purposes began in the late sixties as a result of the papers and patents invented by Japanese and American scientists, headed by Kaetsu in Japan and Hoffman in USA. Immobilization of biologically active species in hydrogel matrices, their use as drug delivery systems and enzyme traps as well as the modification of material surfaces to improve biocompatibility and their ability to bond antigens and antibodies had been the main subjects of these investigations. In this article a brief summary of investigations on mechanism and kinetics of radiation formation of hydrogels as well as some examples of commercialized hydrogel biomaterials have been presented.
[1]
J. Rosiak,et al.
Hydroxyl-radical-induced reactions of poly (acrylic acid); a pulse radiolysis, EPR and product study. Part II. Oxygenated aqueous solutions
,
1996
.
[2]
A. Charlesby.
Atomic Radiation and Polymers
,
1960
.
[3]
C. Sonntag,et al.
Oxygen uptake in the radiolysis of aqueous solutions of nucleic acids and their constituents.
,
1982,
International journal of radiation biology and related studies in physics, chemistry, and medicine.
[4]
J. Silverman,et al.
Reaction of hydroxyl radicals with polyethylene oxide in aqueous solution
,
1973
.
[5]
J. Rosiak,et al.
OH‐radical‐induced crosslinking and strand breakage of poly(vinyl alcohol) in aqueous solution in the absence and presence of oxygen. A pulse radiolysis and product study
,
1994
.
[6]
J. Rosiak,et al.
Pulse radiolysis of poly(vinyl methyl ether) in aqueous solution. Formation and structure of primary radicals
,
1999
.
[7]
J. Rosiak,et al.
Hydrogels for biomedical purposes
,
1995
.
[8]
H. Tobita.
Molecular weight distribution in free-radical crosslinking copolymerization
,
1993
.
[9]
J. Rosiak,et al.
Radiation formation of hydrogels for biomedical purposes. Some remarks and comments
,
1995
.
[10]
J. Rosiak,et al.
Pulse radiolysis of poly(ethylene oxide) in aqueous solution. I. Formation of macroradicals
,
1995
.
[11]
N. Peppas.
Hydrogels in Medicine and Pharmacy
,
1987
.