Ultra-weak delayed luminescence in cancer research: a review of the results by the ARETUSA equipment.

The study of the photoinduced ultraweak photon emission in the optical wavelength range, namely the Delayed Luminescence, from human cells and tissues has an increasingly growing interest in view of its possible application in optical biopsy. Due to the low level, dedicated experimental set-up are necessary to reveal such photoluminescence signal. The paper reviews the results obtained in the field of cancer research, by using the experimental equipment for fast ultraweak luminescence analysis ARETUSA developed at the National Southern Laboratories of the National Nuclear Physics Institute (LNS-INFN), in Catania, Italy. Delayed Luminescence signals from normal and cancer cells are compared and the relationship between Delayed Luminescence and apoptosis is investigated.

[1]  F. Musumeci,et al.  Relation between delayed luminescence and functional state in soya seeds , 1994 .

[2]  Chunho Choi,et al.  Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma. , 2005, Cancer letters.

[3]  A. Scordino,et al.  Nonlinear dependence of the delayed luminescence yield on the intensity of irradiation in the framework of a correlated soliton model. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[4]  L. Lanzanó,et al.  Single seed viability checked by delayed luminescence , 2008, European Biophysics Journal.

[5]  S. Kala.  Optical Spectroscopy: A Promising Diagnostic Tool for Breast Lesions , 2011 .

[6]  R. Stolker,et al.  Oxygen‐dependent delayed fluorescence measured in skin after topical application of 5‐aminolevulinic acid , 2011, Journal of biophotonics.

[7]  Francesco Musumeci,et al.  ARETUSA—advanced research equipment for fast ultraweak luminescence analysis: new developments , 2004 .

[8]  P. Jursinic,et al.  Delayed Fluorescence: Current Concepts and Status , 1986 .

[9]  Francesco Musumeci,et al.  Discrimination between normal and cancer cells by using spectral analysis of delayed luminescence. , 2005 .

[10]  A. Scordino,et al.  Analogous features of delayed luminescence from Acetabularia acetabulum and some solid state systems. , 2000, Journal of photochemistry and photobiology. B, Biology.

[11]  Can Ince,et al.  Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX , 2006, Nature Methods.

[12]  A. Scordino,et al.  The soliton mechanism of the delayed luminescence of biological systems , 2000 .

[13]  Werner Schmidt,et al.  Long term delayed luminescence: A possible fast and convenient assay for nutrition deficiencies and environmental pollution damages in plants , 1988, Plant and Soil.

[14]  Guoguang Mu,et al.  Physical mechanism of delayed luminescence from human serum , 2009, BiOS.

[15]  B. Valeur,et al.  Mathematical functions for the analysis of luminescence decays with underlying distributions 1. Kohlrausch decay function (stretched exponential) , 2005 .

[16]  A. Heikal,et al.  Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level. , 2009, Journal of photochemistry and photobiology. B, Biology.

[17]  Francesco Musumeci,et al.  Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence. , 2005, Journal of photochemistry and photobiology. B, Biology.

[18]  Jinglu Tan,et al.  A kinetic model structure for delayed fluorescence from plants , 2009, Biosyst..

[19]  Gerardo del Cerro Santamaría,et al.  Naturally-occurring porphyrins in a spontaneous-tumour bearing mouse model , 2011, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[20]  Irina Baran,et al.  Detailed Analysis of Apoptosis and Delayed Luminescence of Human Leukemia Jurkat T Cells after Proton Irradiation and Treatments with Oxidant Agents and Flavonoids , 2012, Oxidative medicine and cellular longevity.

[21]  G. Cuttone,et al.  EFFECTS OF NOCODAZOLE AND IONIZING RADIATION ON CELL PROLIFERATION AND DELAYED LUMINESCENCE , 2009 .

[22]  Can Ince,et al.  In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique. , 2008, Biophysical journal.

[23]  Jean-Pierre Mazat,et al.  The flitting of electrons in complex I: a stochastic approach. , 2010, Biochimica et biophysica acta.

[24]  G. Selivanova,et al.  Protoporphyrin IX Interacts with Wild-type p53 Protein in Vitro and Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent Manner* , 2007, Journal of Biological Chemistry.

[25]  M. Kasha,et al.  Chemiluminescence arising from simultaneous transitions in pairs of singlet oxygen molecules , 1970 .

[26]  Govindjee.  Bioenergetics of photosynthesis , 1975 .

[27]  M. Wikström,et al.  Real-time electron transfer in respiratory complex I , 2008, Proceedings of the National Academy of Sciences.

[28]  F. Musumeci,et al.  Influence of the presence of atrazine in water on the in-vivo delayed luminescence of Acetabularia acetabulum , 1996 .

[29]  J. Martinou,et al.  Mitochondria as the central control point of apoptosis. , 2000, Trends in cell biology.

[30]  C. Scaletta,et al.  Ultraweak photon emission in assessing bone growth factor efficiency using fibroblastic differentiation. , 2001, Journal of photochemistry and photobiology. B, Biology.

[31]  N. Kollias,et al.  A chemiluminescence study of UVA-induced oxidative stress in human skin in vivo. , 2004, The Journal of investigative dermatology.

[32]  F Musumeci,et al.  Delayed luminescence of biological systems arising from correlated many-soliton states. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[33]  Francesco Musumeci,et al.  Laser-ultraviolet-A induced ultra weak photon emission in human skin cells: A biophotonic comparison between keratinocytes and fibroblasts. , 2008, Indian journal of experimental biology.

[34]  Francesco Musumeci,et al.  ‘Simultaneous’ measurements of delayed luminescence and chloroplast organization in Acetabularia acetabulum , 1999 .

[35]  Bernard Valeur,et al.  Mathematical functions for the analysis of luminescence decays with underlying distributions: 2. Becquerel (compressed hyperbola) and related decay functions , 2005 .

[36]  Irina Baran,et al.  Effects of Menadione, Hydrogen Peroxide, and Quercetin on Apoptosis and Delayed Luminescence of Human Leukemia Jurkat T-Cells , 2010, Cell Biochemistry and Biophysics.

[37]  Irina Baran,et al.  Mitochondrial respiratory complex I probed by delayed luminescence spectroscopy , 2013, Journal of biomedical optics.

[38]  P. Felker,et al.  Effects of electron transport inhibitors on millisecond delayed light emission from chloroplasts. , 1973, Biochimica et biophysica acta.

[39]  Francesco Musumeci,et al.  Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool , 2007, European Biophysics Journal.

[40]  W. Nagl,et al.  Light-stimulated ultraweak photon reemission of human amnion cells and wish cells , 1988, Cell Biophysics.

[41]  K Svanberg,et al.  FLUORESCENCE IMAGING AND POINT MEASUREMENTS OF TISSUE: APPLICATIONS TO THE DEMARCATION OF MALIGNANT TUMORS AND ATHEROSCLEROTIC LESIONS FROM NORMAL TISSUE , 1991, Photochemistry and photobiology.

[42]  F. Popp,et al.  Hyperbolic relaxation as a sufficient condition of a fully coherent ergodic field , 1993 .

[43]  L. Lanzanó,et al.  Delayed luminescence of microalgae as an indicator of metal toxicity , 2008 .

[44]  Lei Zhang,et al.  Spectral discrimination between normal and leukemic human sera using delayed luminescence , 2012, Biomedical optics express.

[45]  Bernard L. Strehler,et al.  LIGHT PRODUCTION BY GREEN PLANTS , 1951, The Journal of general physiology.

[46]  Francesco Musumeci,et al.  Delayed Luminescence as an Indicator of Tomato Fruit Quality , 1998 .

[47]  F. A. Popp,et al.  Delayed luminescence of biological systems in terms of coherent states , 2002 .

[48]  J. Paul Robinson,et al.  Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production* , 2003, The Journal of Biological Chemistry.

[49]  Melissa C. Skala,et al.  Optical imaging of metabolism in HER2 overexpressing breast cancer cells , 2011, Biomedical optics express.

[50]  F A Popp,et al.  Light-induced photon emission by mammalian cells. , 1993, Journal of photochemistry and photobiology. B, Biology.

[51]  Agata Scordino,et al.  Laser-ultraviolet-A-induced ultraweak photon emission in mammalian cells. , 2005, Journal of biomedical optics.

[52]  Pavel Pospíšil,et al.  Ultraweak photon emission induced by visible light and ultraviolet A radiation via photoactivated skin chromophores: in vivo charge coupled device imaging. , 2012, Journal of biomedical optics.