Functional Streams and Cortical Integration in the Human Brain

The processing of brain information relies on the organization of neuronal networks and circuits that in the end must provide the substrate for human cognition. However, the presence of highly complex and multirelay neuronal interactions has limited our ability to disentangle the assemblies of brain systems. The present review article focuses on the latest developments to understand the architecture of functional streams of the human brain at the large-scale level. Particularly, this article presents a comprehensive framework and recent findings about how the highly modular sensory cortex, such as the visual, somatosensory, auditory, as well as motor cortex areas, connects to more parallel-organized cortical hubs in the brain’s functional connectome.

[1]  Cathy J. Price,et al.  A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading , 2012, NeuroImage.

[2]  D. Poeppel,et al.  The cortical organization of speech processing , 2007, Nature Reviews Neuroscience.

[3]  Peter Hagoort,et al.  Topographical functional connectivity pattern in the perisylvian language networks. , 2010, Cerebral cortex.

[4]  G. Ugolini,et al.  Advances in viral transneuronal tracing , 2010, Journal of Neuroscience Methods.

[5]  D. V. Essen,et al.  Surface-Based and Probabilistic Atlases of Primate Cerebral Cortex , 2007, Neuron.

[6]  K. Amunts,et al.  Broca's region subserves imagery of motion: A combined cytoarchitectonic and fMRI study , 2000, Human brain mapping.

[7]  G. Rizzolatti,et al.  Activation of human primary motor cortex during action observation: a neuromagnetic study. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Cornelius Weiller,et al.  How the ventral pathway got lost – And what its recovery might mean , 2011, Brain and Language.

[9]  C. Keysers,et al.  Social Neuroscience: Mirror Neurons Recorded in Humans , 2010, Current Biology.

[10]  D. Howes,et al.  The Nature of Conduction Aphasia: A Study of Anatomic and Clinical Features and of Underlying Mechanisms , 1977 .

[11]  N. Geschwind,et al.  Wernicke's Contribution to the Study of Aphasia , 1967 .

[12]  Volkmar Glauche,et al.  Ventral and dorsal pathways for language , 2008, Proceedings of the National Academy of Sciences.

[13]  O. Sporns,et al.  Organization, development and function of complex brain networks , 2004, Trends in Cognitive Sciences.

[14]  Leslie G. Ungerleider,et al.  Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys , 1982, Behavioural Brain Research.

[15]  Mert R. Sabuncu,et al.  The influence of head motion on intrinsic functional connectivity MRI , 2012, NeuroImage.

[16]  G. Rizzolatti,et al.  The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations , 2010, Nature Reviews Neuroscience.

[17]  P. T. Fox,et al.  Positron emission tomographic studies of the cortical anatomy of single-word processing , 1988, Nature.

[18]  Timothy Edward John Behrens,et al.  Anatomical and Functional Connectivity of Cytoarchitectonic Areas within the Human Parietal Operculum , 2010, The Journal of Neuroscience.

[19]  M. Fox,et al.  Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging , 2007, Nature Reviews Neuroscience.

[20]  G. Rizzolatti,et al.  Premotor cortex and the recognition of motor actions. , 1996, Brain research. Cognitive brain research.

[21]  Olaf Sporns,et al.  Network attributes for segregation and integration in the human brain , 2013, Current Opinion in Neurobiology.

[22]  G. Rizzolatti,et al.  Understanding motor events: a neurophysiological study , 2004, Experimental Brain Research.

[23]  Timothy E. J. Behrens,et al.  Human connectomics , 2012, Current Opinion in Neurobiology.

[24]  R. Wise,et al.  Two Tongues, One Brain: Imaging Bilingual Speech Production , 2011, Front. Psychology.

[25]  A. Schleicher,et al.  The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions. , 2006, Cerebral cortex.

[26]  Jorge Sepulcre,et al.  An OP4 functional stream in the language-related neuroarchitecture. , 2015, Cerebral cortex.

[27]  Keith A. Johnson,et al.  Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease , 2009, The Journal of Neuroscience.

[28]  D. J. Felleman,et al.  Distributed hierarchical processing in the primate cerebral cortex. , 1991, Cerebral cortex.

[29]  M. Corbetta,et al.  Control of goal-directed and stimulus-driven attention in the brain , 2002, Nature Reviews Neuroscience.

[30]  A R Damasio,et al.  The anatomical basis of conduction aphasia. , 1980, Brain : a journal of neurology.

[31]  Karl J. Friston,et al.  Evidence of Mirror Neurons in Human Inferior Frontal Gyrus , 2009, The Journal of Neuroscience.

[32]  G. Rizzolatti,et al.  Two different streams form the dorsal visual system: anatomy and functions , 2003, Experimental Brain Research.

[33]  B. Biswal,et al.  Functional connectivity in the motor cortex of resting human brain using echo‐planar mri , 1995, Magnetic resonance in medicine.

[34]  J. M. Anderson,et al.  Conduction Aphasia and the Arcuate Fasciculus: A Reexamination of the Wernicke–Geschwind Model , 1999, Brain and Language.

[35]  Alison J. Wiggett,et al.  Surface-Based Information Mapping Reveals Crossmodal Vision–Action Representations in Human Parietal and Occipitotemporal Cortex , 2010, Journal of neurophysiology.

[36]  Harold Goodglass,et al.  Diagnosis of Conduction Aphasia , 2013 .

[37]  H. Tanabe,et al.  Conduction aphasia and arcuate fasciculus , 1987, Acta neurologica Scandinavica.

[38]  Sophie K Scott,et al.  Auditory processing — speech, space and auditory objects , 2005, Current Opinion in Neurobiology.

[39]  M. Catani,et al.  The arcuate fasciculus and the disconnection theme in language and aphasia: History and current state , 2008, Cortex.

[40]  Satrajit S. Ghosh,et al.  Neural modeling and imaging of the cortical interactions underlying syllable production , 2006, Brain and Language.

[41]  R. Wise,et al.  Sounds do-able: auditory–motor transformations and the posterior temporal plane , 2005, Trends in Neurosciences.

[42]  T. Powell,et al.  An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. , 1970, Brain : a journal of neurology.

[43]  G. Rizzolatti,et al.  Both of Us Disgusted in My Insula The Common Neural Basis of Seeing and Feeling Disgust , 2003, Neuron.

[44]  Robert Leech,et al.  A comparison of sensory-motor activity during speech in first and second languages. , 2011, Journal of neurophysiology.

[45]  Christian Windischberger,et al.  Toward discovery science of human brain function , 2010, Proceedings of the National Academy of Sciences.

[46]  K. Amunts,et al.  The human parietal operculum. II. Stereotaxic maps and correlation with functional imaging results. , 2006, Cerebral cortex.

[47]  Kayoko Okada,et al.  Area Spt in the Human Planum Temporale Supports Sensory-motor Integration for Speech Processing Establishing the Existence of Distinct Sen- Sory versus Motor Activation Patterns Would Establish That , 2022 .

[48]  N. Turk-Browne Functional Interactions as Big Data in the Human Brain , 2013, Science.

[49]  S. Petersen,et al.  Concepts and principles in the analysis of brain networks , 2011, Annals of the New York Academy of Sciences.

[50]  Gereon R Fink,et al.  The somatotopic organization of cytoarchitectonic areas on the human parietal operculum. , 2007, Cerebral cortex.

[51]  Wolfram Ziegler,et al.  Auditory–motor integration during fast repetition: The neuronal correlates of shadowing , 2009, NeuroImage.

[52]  R. Passingham,et al.  The Preparation, Execution and Suppression of Copied Movements in the Human Brain , 1996 .

[53]  Cornelius Weiller,et al.  The dual loop model: its relation to language and other modalities , 2012, Front. Evol. Neurosci..

[54]  Jorge Sepulcre,et al.  Network assemblies in the functional brain. , 2012, Current opinion in neurology.

[55]  R. Hari,et al.  Temporal dynamics of cortical representation for action. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[56]  J. Decety,et al.  The effects of learning and intention on the neural network involved in the perception of meaningless actions. , 1999, Brain : a journal of neurology.

[57]  J. Mazziotta,et al.  Modulation of motor and premotor activity during imitation of target-directed actions. , 2002, Cerebral cortex.

[58]  Matthew F Glasser,et al.  DTI tractography of the human brain's language pathways. , 2008, Cerebral cortex.

[59]  Jorge Sepulcre,et al.  Integration of visual and motor functional streams in the human brain , 2014, Neuroscience Letters.

[60]  S. Bressler,et al.  Large-scale brain networks in cognition: emerging methods and principles , 2010, Trends in Cognitive Sciences.

[61]  Olaf Sporns,et al.  The human connectome: Origins and challenges , 2013, NeuroImage.

[62]  Katrin Amunts,et al.  Cytoarchitecture of the cerebral cortex—More than localization , 2007, NeuroImage.

[63]  Angela R. Laird,et al.  ALE meta-analysis of action observation and imitation in the human brain , 2010, NeuroImage.

[64]  Kayoko Okada,et al.  Conduction aphasia, sensory-motor integration, and phonological short-term memory – An aggregate analysis of lesion and fMRI data , 2011, Brain and Language.

[65]  S. Cobb Speech and Brain-Mechanisms. , 1960 .

[66]  D. Boussaoud,et al.  Parietal inputs to dorsal versus ventral premotor areas in the macaque monkey: evidence for largely segregated visuomotor pathways , 2002, Experimental Brain Research.

[67]  G. Rizzolatti,et al.  Action recognition in the premotor cortex. , 1996, Brain : a journal of neurology.

[68]  B. T. Thomas Yeo,et al.  The Organization of Local and Distant Functional Connectivity in the Human Brain , 2010, PLoS Comput. Biol..

[69]  Feng Rong,et al.  Sensorimotor Integration in Speech Processing: Computational Basis and Neural Organization , 2011, Neuron.

[70]  C. Keysers,et al.  The Observation and Execution of Actions Share Motor and Somatosensory Voxels in all Tested Subjects: Single-Subject Analyses of Unsmoothed fMRI Data , 2008, Cerebral cortex.

[71]  G. Rizzolatti,et al.  Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study , 2001, The European journal of neuroscience.

[72]  Scott T. Grafton,et al.  Localization of grasp representations in humans by positron emission tomography , 1996, Experimental Brain Research.

[73]  O. Sporns,et al.  Complex brain networks: graph theoretical analysis of structural and functional systems , 2009, Nature Reviews Neuroscience.

[74]  Michael S. Beauchamp,et al.  A neural link between feeling and hearing , 2012 .

[75]  E. Procyk,et al.  Brain activity during observation of actions. Influence of action content and subject's strategy. , 1997, Brain : a journal of neurology.

[76]  J. Driver,et al.  Multisensory Interplay Reveals Crossmodal Influences on ‘Sensory-Specific’ Brain Regions, Neural Responses, and Judgments , 2008, Neuron.

[77]  Arne D. Ekstrom,et al.  Single-Neuron Responses in Humans during Execution and Observation of Actions , 2010, Current Biology.

[78]  Archana Venkataraman,et al.  Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. , 2010, Journal of neurophysiology.

[79]  Patricia S. Goldman TOPOGRAPHY OF COGNITION: Parallel Distributed Networks in Primate Association Cortex , 1988 .

[80]  John H. R. Maunsell,et al.  The connections of the middle temporal visual area (MT) and their relationship to a cortical hierarchy in the macaque monkey , 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[81]  N. Geschwind Disconnexion syndromes in animals and man. I. , 1965, Brain : a journal of neurology.

[82]  Michela Gamberini,et al.  The Most Direct Visual Pathway to the Frontal Cortex , 2004, Cortex.

[83]  M. Goodale,et al.  The visual brain in action , 1995 .

[84]  G. Mcreddie Aphasia , 1868, The Indian medical gazette.

[85]  Leslie G. Ungerleider,et al.  ‘What’ and ‘where’ in the human brain , 1994, Current Opinion in Neurobiology.

[86]  Keith A. Johnson,et al.  Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain , 2012, The Journal of Neuroscience.

[87]  Angela D. Friederici,et al.  Pathways to language: fiber tracts in the human brain , 2009, Trends in Cognitive Sciences.

[88]  O. Sporns,et al.  Identification and Classification of Hubs in Brain Networks , 2007, PloS one.