Atopic dermatitis.

Received March 16, 2010, Revised April 28, 2010, Accepted for publication April 30, 2010 Corresponding author: Thomas Bieber, M.D., Ph.D., Department of Dermatology and Allergy, Rheinische Friedrich-Wilhelms-University Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. Tel: 49-228287-1-4388, Fax: 49-228-287-1-4881, E-mail: Thomas.Bieber@ukb. uni-bonn.de Ann Dermatol Vol. 22, No. 2, 2010 DOI: 10.5021/ad.2010.22.2.125

[1]  H. Degreef,et al.  Atopic dermatitis: triggering factors. , 1994, Journal of the American Academy of Dermatology.

[2]  Kathleen M. Smith,et al.  Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP , 2002, Nature Immunology.

[3]  N. Reynolds,et al.  Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial , 2006, The Lancet.

[4]  Yong‐jun Liu,et al.  Thymic stromal lymphopoietin: master switch for allergic inflammation , 2006, The Journal of experimental medicine.

[5]  G. Schuler,et al.  Infliximab in the treatment of moderate to severe atopic dermatitis. , 2005, Journal of the American Academy of Dermatology.

[6]  H. Maibach,et al.  Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus Aureus. , 2004, American journal of clinical dermatology.

[7]  J. Ring,et al.  Atopy patch test with different vehicles and allergen concentrations: an approach to standardization. , 1995, The Journal of allergy and clinical immunology.

[8]  M. Steinhoff,et al.  Cytokines and chemokines orchestrate atopic skin inflammation. , 2006, The Journal of allergy and clinical immunology.

[9]  D. Leung.  Immunopathology of atopic dermatitis , 2004, Springer Seminars in Immunopathology.

[10]  H. Sampson,et al.  Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. , 1993, The Journal of clinical investigation.

[11]  R. Valenta,et al.  Autoimmunity and atopic dermatitis , 2004, Current opinion in allergy and clinical immunology.

[12]  D. Margolis,et al.  Lack of Association between Exposure to Topical Calcineurin Inhibitors and Skin Cancer in Adults , 2007, Dermatology.

[13]  T. Bieber,et al.  Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis , 2007, Allergy.

[14]  Q. Hamid,et al.  Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. , 1994, The Journal of clinical investigation.

[15]  N. Reynolds,et al.  Azathioprine for atopic dermatitis , 2001, Clinical and experimental dermatology.

[16]  T. Werfel,et al.  Safety and Efficacy of Topical Calcineurin Inhibitors in the Treatment of Childhood Atopic Dermatitis , 2005, American journal of clinical dermatology.

[17]  J. Saurat,et al.  Consensus Statement on the Safety Profile of Topical Calcineurin Inhibitors , 2005, Dermatology.

[18]  H. Hönigsmann,et al.  Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. , 2003, Journal of the American Academy of Dermatology.

[19]  M. Mihm,et al.  The structure of normal skin and the morphology of atopic eczema. , 1976, The Journal of investigative dermatology.

[20]  M. Akiyama,et al.  Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. , 2007, The Journal of allergy and clinical immunology.

[21]  K. Nishioka.  [Clinical practice of atopic dermatitis]. , 1997, Arerugi = [Allergy].

[22]  H. Williams,et al.  Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema , 2002, BMJ : British Medical Journal.

[23]  A. Finlay,et al.  Update on the use of ciclosporin in immune‐mediated dermatoses , 2006, The British journal of dermatology.

[24]  J. Travers,et al.  Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes 1 , 2003, The Journal of Immunology.

[25]  J. Namkung,et al.  Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables , 2006, The British journal of dermatology.

[26]  L. Liang,et al.  Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus , 2008, PLoS genetics.

[27]  T. Bieber,et al.  Proactive therapy of atopic dermatitis – an emerging concept , 2009, Allergy.

[28]  D. Cohen,et al.  Treatment of recalcitrant atopic dermatitis with omalizumab. , 2006, Journal of the American Academy of Dermatology.

[29]  D. Strachan,et al.  Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys , 2006, The Lancet.

[30]  M. Moffatt,et al.  Filaggrin mutations in children with severe atopic dermatitis. , 2007, The Journal of investigative dermatology.

[31]  L. Beck,et al.  Innate immune defects in atopic dermatitis. , 2006, The Journal of allergy and clinical immunology.

[32]  R. Fölster-Holst,et al.  Skin barrier function, epidermal proliferation and differentiation in eczema. , 2006, Journal of dermatological science.

[33]  J. Stalder,et al.  Local steroid therapy and bacterial skin flora in atopic dermatitis , 1994, The British journal of dermatology.

[34]  C. Palmer,et al.  Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. , 2007, The Journal of investigative dermatology.

[35]  D. Leung,et al.  Role of Bacterial Superantigens in Atopic Dermatitis , 2006, American journal of clinical dermatology.

[36]  T. Keil,et al.  Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. , 2006, The Journal of allergy and clinical immunology.

[37]  R. Geha,et al.  Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. , 1998, The Journal of clinical investigation.

[38]  H. Hönigsmann,et al.  High-dose versus medium-dose UVA1 phototherapy for patients with severe generalized atopic dermatitis. , 2001, Journal of the American Academy of Dermatology.

[39]  Q. Hamid,et al.  Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions. , 2003, The Journal of allergy and clinical immunology.

[40]  T. Chatila,et al.  The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. , 1997, The New England journal of medicine.

[41]  L. Ou,et al.  Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. , 2006, The Journal of allergy and clinical immunology.

[42]  P. Schmid‐Grendelmeier,et al.  IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. , 2005, The Journal of allergy and clinical immunology.

[43]  Wilkinson.  Fusidic acid in dermatology , 1998, The British journal of dermatology.

[44]  C. Paul,et al.  Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis. , 2007, The Journal of investigative dermatology.

[45]  S. Feldman,et al.  Use of the Self‐Administered Eczema Area and Severity Index by parent caregivers: results of a validation study , 2002, The British journal of dermatology.

[46]  J. Ring,et al.  Atopic eczema, Langerhans cells and allergy. , 1991, International archives of allergy and applied immunology.

[47]  K. Barnes,et al.  Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. , 2009, The Journal of allergy and clinical immunology.

[48]  H. Williams,et al.  How epidemiology has challenged 3 prevailing concepts about atopic dermatitis. , 2006, The Journal of allergy and clinical immunology.

[49]  V. Rutten,et al.  Immune dysregulation in atopic dermatitis. , 2002, Veterinary immunology and immunopathology.

[50]  W. Sauerbrei,et al.  Development and validation of diagnostic scores for atopic dermatitis incorporating criteria of data quality and practical usefulness. , 1996, Journal of clinical epidemiology.

[51]  M. McCarthy,et al.  Identifying genes predisposing to atopic eczema. , 1999, The Journal of allergy and clinical immunology.

[52]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[53]  H. Williams,et al.  Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. , 2004, The Journal of investigative dermatology.

[54]  James F. Jones,et al.  Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. , 2006, Immunity.

[55]  T. Bieber,et al.  Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment , 2008, Allergy.

[56]  B. Niggemann,et al.  The cradle of IgE autoreactivity in atopic eczema lies in early infancy. , 2005, The Journal of allergy and clinical immunology.

[57]  S. Hsu,et al.  Failure of omalizumab for treatment of severe adult atopic dermatitis. , 2005, Journal of the American Academy of Dermatology.

[58]  Tomas Ganz,et al.  Endogenous antimicrobial peptides and skin infections in atopic dermatitis. , 2002, The New England journal of medicine.

[59]  A. Giannetti,et al.  The role of topical calcineurin inhibitors in atopic dermatitis: , 2004, The British journal of dermatology.

[60]  N. Novak,et al.  Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis? , 2006, The Journal of allergy and clinical immunology.

[61]  E. Peters,et al.  Neurotrophins Act as Neuroendocrine Regulators of Skin Homeostasis in Health and Disease , 2007, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[62]  Colin N A Palmer,et al.  Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis , 2006, Nature Genetics.

[63]  R. Fimmers,et al.  Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema. , 2005, The Journal of allergy and clinical immunology.

[64]  A. Kramer,et al.  Efficacy and safety of silver textile in the treatment of atopic dermatitis (AD) , 2006, Current medical research and opinion.

[65]  K. Dietz,et al.  Deficiency of Dermcidin-Derived Antimicrobial Peptides in Sweat of Patients with Atopic Dermatitis Correlates with an Impaired Innate Defense of Human Skin In Vivo1 , 2005, The Journal of Immunology.

[66]  R. Damstra,et al.  Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study , 2003, BMJ : British Medical Journal.

[67]  N. Holm,et al.  Atopic dermatitis in a population based twin series. Concordance rates and heritability estimation. , 1985, Acta dermato-venereologica. Supplementum.

[68]  K. Barnes.  An update on the genetics of atopic dermatitis: scratching the surface in 2009. , 2010, The Journal of allergy and clinical immunology.

[69]  M. Worm,et al.  Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi‐centre, randomized, dose–response study , 2006, Allergy.

[70]  N. Klopp,et al.  Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. , 2006, The Journal of allergy and clinical immunology.

[71]  J. Krutmann,et al.  Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. , 1995, The Journal of investigative dermatology.

[72]  R. Hay,et al.  The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. , 1994, The British journal of dermatology.

[73]  A. Bosio,et al.  Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. , 2006, The Journal of allergy and clinical immunology.

[74]  R. Valenta,et al.  Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. , 1998, The Journal of investigative dermatology.

[75]  Q. Hamid,et al.  Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus. , 2007, The Journal of allergy and clinical immunology.

[76]  A. Kapp,et al.  Neuroimmunological findings in allergic skin diseases , 2005, Current opinion in allergy and clinical immunology.

[77]  T. Beaty,et al.  Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. , 2009, The Journal of allergy and clinical immunology.

[78]  S. Grabbe,et al.  Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide , 1993, Nature.

[79]  Thomas Bieber,et al.  Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. , 2004, The Journal of allergy and clinical immunology.

[80]  T. Bieber,et al.  The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis. , 2005, Journal of the American Academy of Dermatology.

[81]  C. Bruijnzeel-Koomen,et al.  A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. , 1998, Immunology today.

[82]  Takami Yoshida,et al.  Correlation of house dust mite-specific lymphocyte proliferation with IL-5 production, eosinophilia, and the severity of symptoms in infants with atopic dermatitis. , 2011, The Journal of allergy and clinical immunology.

[83]  R. Bergström,et al.  The antipruritic effect of a sedative and a non‐sedative antihistamine in atopic dermatitis , 1990, The British journal of dermatology.

[84]  A. Wollenberg,et al.  Viral infections in atopic dermatitis: pathogenic aspects and clinical management. , 2003, The Journal of allergy and clinical immunology.

[85]  R. Dawe,et al.  Ultraviolet A1 phototherapy , 2003, The British journal of dermatology.

[86]  U. Wahn,et al.  Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial , 2006, BMJ : British Medical Journal.

[87]  S. Silva,et al.  Influence of narrow‐band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis , 2006, Journal of the European Academy of Dermatology and Venereology : JEADV.

[88]  M. D. de Bruin‐Weller,et al.  Efficacy and safety of long‐term treatment with cyclosporin A for atopic dermatitis , 2007, Journal of the European Academy of Dermatology and Venereology : JEADV.

[89]  T. Makino,et al.  Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis , 2002, The British journal of dermatology.

[90]  D. Margolis,et al.  A systematic review of the safety of topical therapies for atopic dermatitis , 2007, The British journal of dermatology.

[91]  N. Cassano,et al.  Infliximab in recalcitrant severe atopic eczema associated with contact allergy. , 2006, International journal of immunopathology and pharmacology.

[92]  R. Fimmers,et al.  Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis. , 2002, The Journal of investigative dermatology.

[93]  T. Biedermann,et al.  TH1 and TH2 lymphocyte development and regulation of TH cell-mediated immune responses of the skin. , 2004, The journal of investigative dermatology. Symposium proceedings.

[94]  A. Taïeb,et al.  Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. , 1993, Dermatology.

[95]  L. Picker,et al.  Evidence for superantigen involvement in skin homing of T cells in atopic dermatitis. , 1999, The Journal of investigative dermatology.