Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

ABSTRACT The endothelial cell interactions of homozygous null mutants ofCandida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicansadherence to endothelial cells.

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