A comparative study on nonparametric estimation procedures for survival quantiles

Abstract In survival or reliability data analysis, it is often useful to estimate the quantiles of the lifetime distribution, such as the median time to failure. Different nonparametric methods can construct confidence intervals for the quantiles of the lifetime distributions, some of which are implemented in commonly used statistical software packages. We here investigate the performance of different interval estimation procedures under a variety of settings with different censoring schemes. Our main objectives in this paper are to (i) evaluate the performance of confidence intervals based on the transformation approach commonly used in statistical software, (ii) introduce a new density-estimation-based approach to obtain confidence intervals for survival quantiles, and (iii) compare it with the transformation approach. We provide a comprehensive comparative study and offer some useful practical recommendations based on our results. Some numerical examples are presented to illustrate the methodologies developed.

[1]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[2]  George Iliopoulos,et al.  Adaptive progressive Type-II censoring , 2010 .

[3]  Narayanaswamy Balakrishnan,et al.  Progressive censoring methodology: an appraisal , 2007 .

[4]  Katharina Burger,et al.  Counting Processes And Survival Analysis , 2016 .

[5]  Zhiliang Ying,et al.  A note on the asymptotic properties of the product-limit estimator on the whole line , 1989 .

[6]  Narayanaswamy Balakrishnan,et al.  The Art of Progressive Censoring: Applications to Reliability and Quality , 2014 .

[7]  J. Bert Keats,et al.  Statistical Methods for Reliability Data , 1999 .

[8]  D. Harrington,et al.  Counting Processes and Survival Analysis: Fleming/Counting , 2005 .

[9]  Emil Frei,et al.  The Effect of 6-Mercaptopurine on the Duration of Steroid-induced Remissions in Acute Leukemia: A Model for Evaluation of Other Potentially Useful Therapy , 1963 .

[10]  Wayne B. Nelson,et al.  Applied Life Data Analysis: Nelson/Applied Life Data Analysis , 2005 .

[11]  John D. Emerson,et al.  Nonparametwic Confidence Intervals for the Median in the Presence of Right CensoriIlg , 1982 .

[12]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[13]  H. Ramlau-Hansen Smoothing Counting Process Intensities by Means of Kernel Functions , 1983 .

[14]  N. Balakrishnan,et al.  Progressive Censoring: Theory, Methods, and Applications , 2000 .

[15]  R. Strawderman,et al.  Accurate Bootstrap Confidence Limits for the Cumulative Hazard and Survivor Functions under Random Censoring , 1997 .

[16]  Bradley Efron,et al.  Censored Data and the Bootstrap , 1981 .

[17]  Wayne Nelson,et al.  Applied life data analysis , 1983 .

[18]  D P Byar,et al.  A comparison of reflected versus test-based confidence intervals for the median survival time, based on censored data. , 1984, Biometrics.

[19]  Robert L. Strawderman,et al.  Accurate confidence limits for quantiles under random censoring. , 1997, Biometrics.

[20]  Niels Keiding,et al.  Statistical Models Based on Counting Processes , 1993 .

[21]  W. Nelson Statistical Methods for Reliability Data , 1998 .

[22]  I. Langner Survival Analysis: Techniques for Censored and Truncated Data , 2006 .

[23]  S. Wyard,et al.  THE NATURAL DURATION OF CANCER , 1925, Canadian Medical Association journal.

[24]  Christopher Jennison,et al.  Repeated confidence intervals for the median survival time , 1985 .

[25]  Odd Aalen,et al.  Nonparametric Estimation of Partial Transition Probabilities in Multiple Decrement Models , 1978 .

[26]  Ron Brookmeyer,et al.  A Confidence Interval for the Median Survival Time , 1982 .

[27]  Jia-gang Wang,et al.  A Note on the Uniform Consistency of the Kaplan-Meier Estimator , 1987 .

[28]  W. S. Lazarus-Barlow,et al.  THE NATURAL DURATION OF CANCER , 1924, British medical journal.