A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts.

[1]  R. Kamm,et al.  Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature. , 2021, Lab on a chip.

[2]  K. Roy,et al.  A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases. , 2020, Lab on a chip.

[3]  R. Kamm,et al.  The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform , 2020, bioRxiv.

[4]  S. Bhatia,et al.  Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues , 2020, Advanced functional materials.

[5]  R. Kamm,et al.  Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model , 2020, Advanced functional materials.

[6]  R. Kamm,et al.  Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF‐Ang‐Tie2 Signaling , 2019, Advanced science.

[7]  S. Gerecht,et al.  Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs , 2019, Advanced biosystems.

[8]  Roger D Kamm,et al.  An on-chip model of protein paracellular and transcellular permeability in the microcirculation. , 2019, Biomaterials.

[9]  Thomas A. Slater,et al.  Insulin-like growth factor binding proteins and angiogenesis: from cancer to cardiovascular disease. , 2019, Cytokine & growth factor reviews.

[10]  A. Saalbach,et al.  Thy‐1: more than a marker for mesenchymal stromal cells , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  T. Barker,et al.  Thy-1 in Integrin Mediated Mechanotransduction , 2019, Front. Cell Dev. Biol..

[12]  R. Morris.  Thy-1, a Pathfinder Protein for the Post-genomic Era , 2018, Front. Cell Dev. Biol..

[13]  Heng-Ching Wen,et al.  PMA inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1 , 2018, Scientific Reports.

[14]  Jie Lin,et al.  IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma , 2018, Oncogene.

[15]  A. Kozubík,et al.  The fibroblast surface markers FAP, anti‐fibroblast, and FSP are expressed by cells of epithelial origin and may be altered during epithelial‐to‐mesenchymal transition , 2018, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[16]  Wei Li,et al.  BAP1 links metabolic regulation of ferroptosis to tumor suppression , 2018, Nature Cell Biology.

[17]  Roger D Kamm,et al.  3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes. , 2018, Biomaterials.

[18]  O. Guenat,et al.  Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitro , 2018, Angiogenesis.

[19]  Wei Chen,et al.  PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation , 2018, The Journal of cell biology.

[20]  Cécile M. Bidan,et al.  Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts , 2018, Science Advances.

[21]  I. Sekiya,et al.  Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells , 2017, Cell transplantation.

[22]  Roger D Kamm,et al.  Advances in on-chip vascularization. , 2017, Regenerative medicine.

[23]  Roger D Kamm,et al.  On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics , 2017, Nature Protocols.

[24]  Soo-Hyun Park,et al.  The Role of Insulin-Like Growth Factor Binding Protein 2 (IGFBP2) in the Regulation of Corneal Fibroblast Differentiation. , 2015, Investigative ophthalmology & visual science.

[25]  Noo Li Jeon,et al.  Engineering of a Biomimetic Pericyte-Covered 3D Microvascular Network , 2015, PloS one.

[26]  J. Lou,et al.  The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold , 2015, eLife.

[27]  J. Simon,et al.  Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1. , 2015, The Journal of investigative dermatology.

[28]  W. Holnthoner,et al.  Mechanisms of vasculogenesis in 3D fibrin matrices mediated by the interaction of adipose-derived stem cells and endothelial cells , 2014, Angiogenesis.

[29]  José Luis Alonso,et al.  Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin , 2014, Nature Structural &Molecular Biology.

[30]  Roger D Kamm,et al.  Control of perfusable microvascular network morphology using a multiculture microfluidic system. , 2013, Tissue engineering. Part C, Methods.

[31]  F. Auger,et al.  The pivotal role of vascularization in tissue engineering. , 2013, Annual review of biomedical engineering.

[32]  Hyunjae Lee,et al.  Engineering of functional, perfusable 3D microvascular networks on a chip. , 2013, Lab on a chip.

[33]  Yu-Hsiang Hsu,et al.  In vitro perfused human capillary networks. , 2013, Tissue engineering. Part C, Methods.

[34]  P. Fisher,et al.  MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma. , 2013, Cancer research.

[35]  P. Houghton,et al.  Potent Inhibition of Angiogenesis by the IGF-1 Receptor-Targeting Antibody SCH717454 Is Reversed by IGF-2 , 2011, Molecular Cancer Therapeutics.

[36]  Laure Gambardella,et al.  A Computational Tool for Quantitative Analysis of Vascular Networks , 2011, PloS one.

[37]  M. N. Nakatsu,et al.  The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation , 2011, Molecular biology of the cell.

[38]  A. Hoffman,et al.  IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells. , 2011, Endocrinology.

[39]  J. Hagood,et al.  Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses. , 2006, Biochimica et biophysica acta.

[40]  C. B. Alexander,et al.  Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. , 2005, The American journal of pathology.

[41]  J. Hagood,et al.  Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. , 2004, The American journal of pathology.

[42]  M. Ouellette,et al.  Use of exogenous hTERT to immortalize primary human cells , 2004, Cytotechnology.

[43]  Joseph J. Pereira,et al.  Bimolecular Interaction of Insulin-Like Growth Factor (IGF) Binding Protein-2 with αvβ3 Negatively Modulates IGF-I-Mediated Migration and Tumor Growth 1 , 2004, Cancer Research.

[44]  Terry J. Smith,et al.  Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. , 2003, The American journal of pathology.

[45]  J. Hagood,et al.  Concordant and discordant interleukin-1-mediated signaling in lung fibroblast thy-1 subpopulations. , 2002, American journal of respiratory cell and molecular biology.

[46]  D. Moyes,et al.  A comparison of primary endothelial cells and endothelial cell lines for studies of immune interactions. , 1999, Transplant immunology.

[47]  R. Looney,et al.  Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. , 1994, Clinical immunology and immunopathology.

[48]  M. Mamrack,et al.  PMA inhibits the growth of human fibroblasts after the induction of immediate-early genes. , 1994, Experimental cell research.

[49]  P. Keng,et al.  Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC. , 1989, American journal of respiratory cell and molecular biology.

[50]  Arnold E. Reif,et al.  THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES , 1964, The Journal of experimental medicine.

[51]  Joan M. V. Allen,et al.  Immunological Distinction of AKR Thymocytes , 1964, Nature.