Controlled trial of methotrexate and Bacillus Calmette-Guérin therapy for advanced head and neck cancer.

Thirty-eight patients with advanced, inoperable squamous cell carcinoma of the head and neck were randomized to receive methotrexate alone or methotrexate with Bacillus Calmette-Guérin. The response rates with methotrexate (3 of 19) and methotrexate plus B. Calmette-Guérin (4 of 16) were similar, as was the duration of response and survival of the two groups. The results of in vitro immunological studies of lymphocytes were assessed. Marked weight loss, poor performance status, and distant metastases were the most important prognostic factors. The presence of anergy was significantly correlated with weight loss. This study also indicated that a large tumor burden is a frequent occurrence in advanced head and neck cancer and may account for the lack of efficacy of B. Calmette-Guérin.

[1]  B. Mukherji,et al.  High dose methotrexate with and without BCG therapy in advanced head and neck malignancy , 1979, Cancer.

[2]  R. Mladick.  Squamous cell carcinoma of the tongue in a nine year renal transplant survivor , 1978 .

[3]  R. Livingston,et al.  Results of BCG adjuvant immunotherapy in 100 patients with epidermoid carcinoma of the head and neck. , 1977, American journal of surgery.

[4]  J. E. Woods,et al.  A controlled study of combined methotrexate, BCG, and INH therapy for squamous cell carcinoma of the head and neck. , 1977, The Surgical clinics of North America.

[5]  H. Rapp,et al.  Regression of bovine ocular carcinoma by treatment with a mycobacterial vaccine. , 1977, Journal of the National Cancer Institute.

[6]  S. Coulthard,et al.  Spontaneous rosette formation and rosette inhibition assays in patients with squamous cell carcinoma of the head and neck , 1977, Cancer.

[7]  R. Livingston,et al.  Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study. , 1976, Cancer treatment reports.

[8]  V. K. Jenkins,et al.  Lymphocyte response in patients with head and neck cancer: effect of clinical stage and radiotherapy. , 1976, Archives of otolaryngology.

[9]  Mason Jm,et al.  T-cell rosette test in squamous cell carcinoma of the head and neck. , 1976 .

[10]  J. Mason,et al.  T-cell rosette test in squamous cell carcinoma of the head and neck. , 1976, Archives of otolaryngology.

[11]  E. Strong,et al.  T-cell deficiency in patients with squamous cell cancer of the head and neck. , 1975, American journal of surgery.

[12]  Z. Olkowski,et al.  T-lymphocyte levels in the peripheral blood of patients with cancer of the head and neck. , 1975, American journal of surgery.

[13]  J. Bertino,et al.  The role of chemotherapy in the management of cancer of the head and neck: A review , 1975, Cancer.

[14]  C. Potvin,et al.  Thymus-derived lymphocytes in patients with solid malignancies. , 1975, Clinical immunology and immunopathology.

[15]  R. Donaldson.  Chemoimmunotherapy for cancer of the head and neck. , 1973, American journal of surgery.

[16]  N. Abdou,et al.  Immunocompetence of patients with protein-calorie malnutrition. , 1973 .

[17]  R. Donaldson.  Methotrexate plus Bacillus Calmette-Guérin (BCG) and isoniazid in the treatment of cancer of the head and neck. , 1972, American journal of surgery.

[18]  P. O'Brien,et al.  Distant metastases in epidermoid cell carcinoma of the head and neck , 1971, Cancer.