SYK is a critical regulator of FLT3 in acute myeloid leukemia.
暂无分享,去创建一个
J. Aster | K. Stegmaier | M. Hemann | G. Alexe | Jinyan Du | D. DeAngelo | I. Galinsky | A. Kung | R. Stone | L. Rönnstrand | F. Luciano | J. U. Kazi | A. Puissant | C. F. Bassil | N. Fenouille | Y. Pikman | S. Mehta | Christopher F. Bassil
[1] M. Crackower,et al. Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction. , 2013, American journal of respiratory cell and molecular biology.
[2] Fatima Al-Shahrour,et al. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. , 2013, Cancer cell.
[3] Benjamin J. Raphael,et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. , 2013, The New England journal of medicine.
[4] H. Urlaub,et al. β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis. , 2013, Blood.
[5] B. Druker,et al. The Selective Syk Inhibitor P505-15 (PRT062607) Inhibits B Cell Signaling and Function In Vitro and In Vivo and Augments the Activity of Fludarabine in Chronic Lymphocytic Leukemia , 2013, The Journal of Pharmacology and Experimental Therapeutics.
[6] G. Nybakken,et al. Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML. , 2012, Blood.
[7] S. Armstrong,et al. Chromatin modifications as therapeutic targets in MLL-rearranged leukemia. , 2012, Trends in immunology.
[8] F. Giles,et al. Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia , 2012, Leukemia.
[9] Andrew Kasarskis,et al. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia , 2012, Nature.
[10] N. Socci,et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. , 2012, The New England journal of medicine.
[11] S. Lowe,et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia , 2011, Nature.
[12] Lars Bullinger,et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. , 2011, Cancer cell.
[13] Yonghong Xiao,et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. , 2011, Cancer cell.
[14] T. Naoe,et al. FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling , 2011, European journal of haematology.
[15] E. Estey,et al. Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] M. Sattler,et al. Drug resistance in mutant FLT3-positive AML , 2010, Oncogene.
[17] Victor L. J. Tybulewicz,et al. The SYK tyrosine kinase: a crucial player in diverse biological functions , 2010, Nature Reviews Immunology.
[18] J. Holch,et al. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma , 2010, The Journal of experimental medicine.
[19] Ronald Levy,et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. , 2010, Blood.
[20] Tina N. Davis,et al. Proteomic and genetic approaches identify Syk as an AML target. , 2009, Cancer cell.
[21] S. Akinaga,et al. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response. , 2009, Blood.
[22] N. Donato,et al. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. , 2008, Blood.
[23] Nick Holford,et al. Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics. , 2006, Blood.
[24] D. Payan,et al. R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation , 2006, Journal of Pharmacology and Experimental Therapeutics.
[25] M. Roussel,et al. Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[26] M. Tomasson,et al. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. , 2005, Blood.
[27] P. De,et al. Molecular Basis for a Direct Interaction between the Syk Protein-tyrosine Kinase and Phosphoinositide 3-Kinase* , 2005, Journal of Biological Chemistry.
[28] R. Clark,et al. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. , 2004 .
[29] F. Lu,et al. The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. , 2004, Molecular cell.
[30] M. Tanimoto,et al. Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12). , 2001, Blood.
[31] H. Umehara,et al. Co-stimulation of T cells with CD2 augments TCR-CD3-mediated activation of protein tyrosine kinase p72syk, resulting in increased tyrosine phosphorylation of adapter proteins, Shc and Cbl. , 1998, International immunology.
[32] R. Geahlen,et al. Syk Activation and Dissociation from the B-cell Antigen Receptor Is Mediated by Phosphorylation of Tyrosine 130* , 1997, The Journal of Biological Chemistry.