Perinatal morbidity and mortality in early‐onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

Few data exist for counseling and perinatal management of women after an antenatal diagnosis of early‐onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching. The objective of this study was to describe perinatal morbidity and mortality following early‐onset fetal growth restriction based on time of antenatal diagnosis and delivery.

[1]  F. P. Hadlock,et al.  Estimation of fetal weight with the use of head, body, and femur measurements--a prospective study. , 1985, American journal of obstetrics and gynecology.

[2]  G. Visser,et al.  Abnormal velocity waveforms of the umbilical artery in growth retarded fetuses: relationship to antepartum late heart rate decelerations and outcome. , 1990, Early human development.

[3]  K. Nicolaides,et al.  Relation of fetal blood gases and data from computer‐assisted analysis of fetal heart rate patterns in small for gestation fetuses , 1991, British journal of obstetrics and gynaecology.

[4]  G S Dawes,et al.  Short–Term Fetal Heart Rate Variation, Decelerations, and Umbilical Flow Velocity Waveforms Before Labor , 1992, Obstetrics and gynecology.

[5]  E. Mulder,et al.  Numeric analysis of heart rate variation in intrauterine growth-retarded fetuses: a longitudinal study. , 1992, American journal of obstetrics and gynecology.

[6]  D. Arduini,et al.  The development of abnormal heart rate patterns after absent end-diastolic velocity in umbilical artery: analysis of risk factors. , 1993, American journal of obstetrics and gynecology.

[7]  K. Nicolaides,et al.  Reference ranges for fetal venous and atrioventricular blood flow parameters , 1994, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[8]  K. Nicolaides,et al.  Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation. Arterial, intracardiac, and venous blood flow velocity studies. , 1995, Circulation.

[9]  KurtHecher,et al.  Assessment of Fetal Compromise by Doppler Ultrasound Investigation of the Fetal Circulation , 1995 .

[10]  K. Hecher,et al.  Cardiotocogram compared to Doppler investigation of the fetal circulation in the premature growth‐retarded fetus: longitudinal observations , 1997, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[11]  Y. Ville,et al.  Monitoring of fetuses with intrauterine growth restriction: a longitudinal study , 2001, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[12]  E. Ferrazzi,et al.  Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth‐restricted fetus , 2002, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[13]  M. Moulden,et al.  A computer system for the numerical analysis of nonstress tests. , 2002, American journal of obstetrics and gynecology.

[14]  D. Spiegelhalter,et al.  A randomised trial of timed delivery for the compromised preterm fetus: short term outcomes and Bayesian interpretation. , 2003, BJOG : an international journal of obstetrics and gynaecology.

[15]  J G Thornton,et al.  Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial , 2004, The Lancet.

[16]  H. Baumgartner,et al.  The TRUFFLE study—a collaborative publicly funded project from concept to reality: how to negotiate an ethical, administrative and funding obstacle course in the European Union , 2005, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[17]  K. Nicolaides,et al.  Predictors of Neonatal Outcome in Early- Onset Placental Dysfunction , 2007, Obstetrics and gynecology.

[18]  K. Maršál,et al.  Early intervention in management of very preterm growth‐restricted fetuses: 2‐year outcome of infants delivered on fetal indication before 30 gestational weeks , 2009, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[19]  L. D. de Vries,et al.  Predictors of outcome at 2 years of age after early intrauterine growth restriction , 2010, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[20]  N. Marlow,et al.  The Growth Restriction Intervention Trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. , 2011, American journal of obstetrics and gynecology.

[21]  Neil Marlow,et al.  Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies) , 2012, BMJ : British Medical Journal.

[22]  Neil Marlow,et al.  Neonatal and infant outcome in boys and girls born very prematurely , 2012, Pediatric Research.