Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

The rosemary plant, Rosmarinus officinalis L., one of the main members of the Lamiaceae family, is currently one of the most promising herbal medicines due to its pharmaceutical properties. This research aimed to evaluate the antioxidant role of Rosmarinus officinalis and its bioactive compounds on the skin, with a focus on the newly emerging molecular mechanisms involved, providing extensive scientific evidence of its anti-inflammatory, antimicrobial, wound-healing and anticancer activity in dermatological practice. The search was conducted on articles concerning in vitro and in vivo studies in both animals and humans. The results obtained confirm the antioxidant role of R. officinalis. This assumption derives the possibility of using R. officinalis or its bioactive elements for the treatment of inflammatory and infectious skin pathologies. However, although the use of rosemary in the treatment of skin diseases represents a fascinating line of research, future perspectives still require large and controlled clinical trials in order to definitively elucidate the real impact of this plant and its components in clinical practice.

[1]  J. Yasunaga Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma , 2023, International Journal of Hematology.

[2]  Seng Joe Lim,et al.  A Comprehensive Review with Future Prospects on the Medicinal Properties and Biological Activities of Curcuma caesia Roxb. , 2023, Evidence-based complementary and alternative medicine : eCAM.

[3]  G. Soliman,et al.  Anticandidal effect of Eucalyptus oil and three isolated compounds on cutaneous wound healing in rats. , 2023, European review for medical and pharmacological sciences.

[4]  Lokender Kumar,et al.  Revisiting the therapeutic potential of gingerols against different pharmacological activities , 2022, Naunyn-Schmiedeberg's Archives of Pharmacology.

[5]  Halima Nazar,et al.  A comprehensive review on medicinal plants possessing antioxidant potential , 2022, Clinical and experimental pharmacology & physiology.

[6]  Zhi Zhang,et al.  Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review. , 2022, Journal of ethnopharmacology.

[7]  Chenhui Zhong,et al.  Tanshinone I: Pharmacological activities, molecular mechanisms against diseases and future perspectives. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[8]  S. Gangemi,et al.  Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives , 2022, Biomolecules.

[9]  N. Kladar,et al.  Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence , 2022, Antibiotics.

[10]  T. G. Singh,et al.  Journey of Rosmarinic Acid as Biomedicine to Nano-Biomedicine for Treating Cancer: Current Strategies and Future Perspectives , 2022, Pharmaceutics.

[11]  J. Jia,et al.  Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells , 2022, Molecular neurobiology.

[12]  G. Pioggia,et al.  Role of HMGB1 in Cutaneous Melanoma: State of the Art , 2022, International journal of molecular sciences.

[13]  J. A. Ataide,et al.  Development and Evaluation of an Antimicrobial Formulation Containing Rosmarinus officinalis , 2022, Molecules.

[14]  N. El-Sayed,et al.  Rosmarinus officinalis L. hexane extract: phytochemical analysis, nanoencapsulation, and in silico, in vitro, and in vivo anti-photoaging potential evaluation , 2022, Scientific Reports.

[15]  Sonal Jain,et al.  Efficacy of polyherbal formulations for prevention of COVID‐19 infection in high‐risk subjects: A randomized open‐label controlled clinical trial , 2022, Phytotherapy research : PTR.

[16]  M. Ribeiro-Alves,et al.  Global distribution of animal sporotrichosis: A systematic review of Sporothrix sp. identified using molecular tools , 2022, Current research in microbial sciences.

[17]  M. Denison,et al.  Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer , 2022, Molecules.

[18]  D. Dafou,et al.  Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases , 2022, Antioxidants.

[19]  J. Vagedes,et al.  Topical Rosmarinus officinalis L. in Systemic Sclerosis-Related Raynaud’s Phenomenon: An Open-Label Pilot Study , 2022, Complementary Medicine Research.

[20]  R. Casagrande,et al.  Rosmarinus officinalis extract-loaded emulgel prevents UVB irradiation damage to the skin. , 2022, Anais da Academia Brasileira de Ciencias.

[21]  Hamza M. Assaggaf,et al.  Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits , 2021, Foods.

[22]  S. Jimenez,et al.  Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target , 2021, Journal of clinical medicine.

[23]  A. Fuentefria,et al.  Can the essential oil of rosemary (Rosmarinus officinalis Linn.) protect rats infected with itraconazole-resistant Sporothrix brasiliensis from fungal spread? , 2021, Journal de Mycologie Médicale.

[24]  J. Qiu,et al.  Oxidative stress in the skin: Impact and related protection , 2021, International Journal of Cosmetic Science.

[25]  G. Valacchi,et al.  Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage , 2021, Molecules.

[26]  J. Knoblauch,et al.  Neural networks and robotic microneedles enable autonomous extraction of plant metabolites. , 2021, Plant physiology.

[27]  Xiongwen Zhang,et al.  Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia , 2021, Journal of cachexia, sarcopenia and muscle.

[28]  T. Asano,et al.  Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells , 2021, International journal of molecular sciences.

[29]  J. Levy,et al.  Combined Effects of Carotenoids and Polyphenols in Balancing the Response of Skin Cells to UV Irradiation , 2021, Molecules.

[30]  S. Giardina,et al.  Antioxidant and reduced skin-ageing effects of a polyphenol-enriched dietary supplement in response to air pollution: a randomized, double-blind, placebo-controlled study , 2021, Food & nutrition research.

[31]  A. Ganesan,et al.  Structure-based virtual screening, molecular dynamics and binding affinity calculations of some potential phytocompounds against SARS-CoV-2 , 2021, Journal of biomolecular structure & dynamics.

[32]  Christopher Ty Williams Herbal Supplements: Precautions and Safe Use. , 2021, The Nursing clinics of North America.

[33]  S. Krau Complementary and Alternative Medications: A Growing Phenomenon. , 2021, The Nursing Clinics of North America.

[34]  A. Farhan,et al.  Evaluation and HPLC characterisation of a new herbal ointment for the treatment of full-thickness burns in rats , 2020, Journal of Taibah University Medical Sciences.

[35]  J. Auh,et al.  Protective effect of a mixture of marigold and rosemary extracts on UV-induced photoaging in mice. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[36]  R. Bauer,et al.  Botanical drugs and supplements affecting the immune response in the time of COVID‐19: Implications for research and clinical practice , 2020, Phytotherapy research : PTR.

[37]  X. Shang,et al.  Chemical characterization of the polar antibacterial fraction of the ethanol extract from Rosmarinus officinalis. , 2020, Food chemistry.

[38]  Ping Li,et al.  Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalis L.) and its Phenolic Components. , 2020, The American journal of Chinese medicine.

[39]  A. Fernie,et al.  Using an UPLC/MS-based untargeted metabolomics approach for assessing the antioxidant capacity and anti-aging potential of selected herbs , 2020, RSC advances.

[40]  E. Souto,et al.  Spouted Bed Dried Rosmarinus officinalis Extract: A Novel Approach for Physicochemical Properties and Antioxidant Activity , 2020 .

[41]  A. Allegra,et al.  Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials , 2020, Nutrients.

[42]  G. Hillebrand,et al.  Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence , 2020, Antibiotics.

[43]  B. Salehi,et al.  Rosmarinus plants: Key farm concepts towards food applications , 2020, Phytotherapy research : PTR.

[44]  Ž. Maleš,et al.  Application of medicinal plants in several dermatovenerological entities , 2019, Acta pharmaceutica.

[45]  Haidy E. Michel,et al.  Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations , 2019, PloS one.

[46]  A. Karadağ,et al.  In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions , 2019, South African Journal of Botany.

[47]  A. Silva,et al.  Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections , 2019, Pharmaceutics.

[48]  R. Parenti,et al.  Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells , 2019, Natural product research.

[49]  J. Carvalho,et al.  Rosmarinus officinalis essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved. , 2019, Journal of ethnopharmacology.

[50]  L. D. de Oliveira,et al.  Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent , 2019, Journal of Biomedical Science.

[51]  J. Hong,et al.  Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3 , 2018, Archives of pharmacal research.

[52]  E. Baracat,et al.  Phytotherapy: yesterday, today, and forever? , 2018, Revista da Associacao Medica Brasileira.

[53]  R. Ben-Ami Treatment of Invasive Candidiasis: A Narrative Review , 2018, Journal of fungi.

[54]  Guang-Xian Zhang,et al.  Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis , 2018, Front. Immunol..

[55]  L. Ratner,et al.  The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma. , 2018, Virology.

[56]  M. Uyar,et al.  Effect of cineole, alpha-pinene, and camphor on survivability of skin flaps , 2018, Turkish journal of medical sciences.

[57]  L. Punzi,et al.  Anti-inflammatory effects of polyphenols in arthritis. , 2018, Journal of the science of food and agriculture.

[58]  Cristiano Colalto What phytotherapy needs: Evidence‐based guidelines for better clinical practice , 2018, Phytotherapy research : PTR.

[59]  Shiyong Wu,et al.  The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation , 2018, Scientific Reports.

[60]  A. Bitto,et al.  Dual αvβ3 and αvβ5 blockade attenuates fibrotic and vascular alterations in a murine model of systemic sclerosis. , 2017, Clinical science.

[61]  É. Hermida,et al.  Could essential oils enhance biopolymers performance for wound healing? A systematic review. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[62]  M. Yimam,et al.  A Standardized Composition Comprised of Extracts from Rosmarinus officinalis, Annona squamosa and Zanthoxylum clava-herculis for Cellulite , 2017, Pharmacognosy research.

[63]  J. Hong,et al.  Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3 , 2017, Biomolecules & therapeutics.

[64]  A. Balabanova,et al.  Phytotherapy: An Introduction to Herbal Medicine. , 2017, Primary care.

[65]  H. Hosseinzadeh,et al.  Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[66]  G. Berta,et al.  Sensitivity of Candida albicans to essential oils: are they an alternative to antifungal agents? , 2016, Journal of applied microbiology.

[67]  B. Ince,et al.  Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps. , 2016, Balkan medical journal.

[68]  S. Waller,et al.  In Vitro Susceptibility of Sporothrix brasiliensis to Essential Oils of Lamiaceae Family , 2016, Mycopathologia.

[69]  S. Waller,et al.  Effects of essential oils of Rosmarinus officinalis Linn. and Origanum vulgare Linn. from different origins on Sporothrix brasiliensis and Sporothrix schenckii complex , 2016 .

[70]  A. Pérez-Sánchez,et al.  Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols , 2016, Food & nutrition research.

[71]  S. Ezzat,et al.  HPLC–DAD–MS/MS profiling of standardized rosemary extract and enhancement of its anti-wrinkle activity by encapsulation in elastic nanovesicles , 2016, Archives of pharmacal research.

[72]  Miguel C. Teixeira,et al.  Clotrimazole Drug Resistance in Candida glabrata Clinical Isolates Correlates with Increased Expression of the Drug:H+ Antiporters CgAqr1, CgTpo1_1, CgTpo3, and CgQdr2 , 2016, Front. Microbiol..

[73]  S. Gangemi,et al.  Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – Part 3: Mentha × piperita – Solanum dulcamara , 2016, Contact dermatitis.

[74]  M. Bigdeli,et al.  The Neuroprotective Effect of Rosemary (Rosmarinus officinalis L.) Hydro-alcoholic Extract on Cerebral Ischemic Tolerance in Experimental Stroke , 2016, Iranian journal of pharmaceutical research : IJPR.

[75]  C. Nakamura,et al.  Antidermatophytic activity of hydroalcoholic extracts from Rosmarinus officinalis and Tetradenia riparia. , 2015, Journal de mycologie medicale.

[76]  M. Otto,et al.  Quorum-sensing regulation in staphylococci—an overview , 2015, Front. Microbiol..

[77]  M. Marra,et al.  Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells , 2015, PloS one.

[78]  Simona Birtić,et al.  Carnosic acid. , 2015, Phytochemistry.

[79]  R. Luiten,et al.  Oxidation events and skin aging , 2015, Ageing Research Reviews.

[80]  M. Rinnerthaler,et al.  Oxidative Stress in Aging Human Skin , 2015, Biomolecules.

[81]  B. Ince,et al.  Effects of Rosmarinus officinalis on the survivability of random-patterned skin flaps: An experimental study , 2015, Journal of plastic surgery and hand surgery.

[82]  T. Tuttolomondo,et al.  Study of quantitative and qualitative variations in essential oils of Sicilian Rosmarinus officinalis L. , 2015, Natural product research.

[83]  G. Tenore,et al.  The cellular protective effects of rosmarinic acid: from bench to bedside. , 2015, Current neurovascular research.

[84]  Gun-Dong Kim,et al.  Production and applications of rosmarinic acid and structurally related compounds , 2015, Applied Microbiology and Biotechnology.

[85]  M. Taghizadeh,et al.  Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. , 2015, Skinmed.

[86]  C. Yamamoto,et al.  Development of mouthwash with Rosmarinus officinalis extract , 2014 .

[87]  A. Rašković,et al.  Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential , 2014, BMC Complementary and Alternative Medicine.

[88]  A. Pérez-Sánchez,et al.  Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. , 2014, Journal of photochemistry and photobiology. B, Biology.

[89]  H. Tsubouchi,et al.  Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis , 2014, Human Cell.

[90]  D. Wedge,et al.  Characterization of volatile constituents from Origanum onites and their antifungal and antibacterial activity. , 2013, Journal of AOAC International.

[91]  E. Kowalczyk,et al.  The Potential of Use Basil and Rosemary Essential Oils as Effective Antibacterial Agents , 2013, Molecules.

[92]  H. Ha,et al.  Carnosic acid, a phenolic diterpene from rosemary, prevents UV‐induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes , 2013, Experimental dermatology.

[93]  H. Rastegar,et al.  Combination of herbal extracts and platelet‐rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways , 2012, Journal of cosmetic dermatology.

[94]  A. Tzakos,et al.  Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. , 2013, Food chemistry.

[95]  P. Sivamani,et al.  Comparative molecular docking analysis of essential oil constituents as elastase inhibitors , 2012, Bioinformation.

[96]  J. Johnson Carnosol: a promising anti-cancer and anti-inflammatory agent. , 2011, Cancer letters.

[97]  M. Kurachi,et al.  [Effects of ethanol extracts of herbal medicines on dermatitis in an atopic dermatitis mouse model]. , 2011, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[98]  A. Vojnov,et al.  Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. , 2011, Fitoterapia.

[99]  David W Williams,et al.  Candida biofilms and oral candidosis: treatment and prevention. , 2011, Periodontology 2000.

[100]  M. Abu-al-basal Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. , 2010, Journal of ethnopharmacology.

[101]  M. Groppo,et al.  Antimicrobial Activity of Rosmarinus officinalis against Oral Pathogens: Relevance of Carnosic Acid and Carnosol , 2010, Chemistry & biodiversity.

[102]  F. Vardar-Sukan,et al.  Inhibitory Effects of Rosemary Extracts, Carnosic Acid and Rosmarinic Acid on the Growth of Various Human Cancer Cell Lines , 2010, Plant foods for human nutrition.

[103]  C. Pereira-Wilson,et al.  Salvia Fruticosa, Salvia Officinalis, and Rosmarinic Acid Induce Apoptosis and Inhibit Proliferation of Human Colorectal Cell Lines: The Role in MAPK/ERK Pathway , 2009, Nutrition and cancer.

[104]  M. Uskoković,et al.  Synergistic Antileukemic Activity of Carnosic Acid-Rich Rosemary Extract and the 19-nor Gemini Vitamin D Analogue in a Mouse Model of Systemic Acute Myeloid Leukemia , 2008, Oncology.

[105]  I. Raskin,et al.  A natural history of botanical therapeutics. , 2008, Metabolism: clinical and experimental.

[106]  Jia Luo,et al.  [Expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis]. , 2008, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.

[107]  Richard Martin,et al.  Photoprotective effect of a water-soluble extract of Rosmarinus officinalis L. against UV-induced matrix metalloproteinase-1 in human dermal fibroblasts and reconstructed skin. , 2008, EJD. European journal of dermatology.

[108]  F Bakkali,et al.  Biological effects of essential oils--a review. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[109]  K. Pelz,et al.  Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[110]  J. Tai,et al.  Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. , 2007, Oncology reports.

[111]  D. Bickers,et al.  Oxidative stress in the pathogenesis of skin disease. , 2006, The Journal of investigative dermatology.

[112]  P. Goyal,et al.  Effect of rosmarinus officinalis in modulating 7,12‐dimethylbenz(a)anthracene induced skin tumorigenesis in mice , 2006, Phytotherapy research : PTR.

[113]  D. Thompson,et al.  Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. , 2006, Cancer letters.

[114]  Jen-kun Lin,et al.  Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. , 2005, Biochemical pharmacology.

[115]  M. Pfaller,et al.  Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyond Candida albicans and Aspergillus fumigatus , 2004, Journal of Clinical Microbiology.

[116]  J. D. del Río,et al.  Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. , 2004, Journal of agricultural and food chemistry.

[117]  M. Ueda,et al.  UV-induced skin damage. , 2003, Toxicology.

[118]  Glenn Merlino,et al.  Ultraviolet radiation and cutaneous malignant melanoma , 2003, Oncogene.

[119]  H. Kim,et al.  Protein glycation inhibitory and antioxidative activities of some plant extracts in vitro. , 2003, Journal of agricultural and food chemistry.

[120]  M. Tomonaga,et al.  Correlation of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. , 2000, Leukemia research.

[121]  K. Singletary,et al.  Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. , 1996, Cancer letters.

[122]  Y. Lou,et al.  Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. , 1994, Cancer research.