This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. A WAO - ARIA - GA2LEN consensus document on molecular-based allergy diagnostics

[1]  R. Valenta,et al.  Heterogeneity of commercial timothy grass pollen extracts , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[2]  H. Grönlund,et al.  Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α 1,3-galactose. , 2011, The Journal of allergy and clinical immunology.

[3]  C. Akdis,et al.  Immunological mechanisms of allergen‐specific immunotherapy , 2011, Allergy.

[4]  R. Giugno,et al.  Characteristics of patients with allergic polysensitization: the POLISMAIL study. , 2008, European annals of allergy and clinical immunology.

[5]  E. Varga,et al.  Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat‐allergic children with asthma compared with rhinoconjunctivitis , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[6]  J. Cuesta-Herranz,et al.  Characterization of peach thaumatin‐like proteins and their identification as major peach allergens , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  H. Grönlund,et al.  The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA. , 2009, The Journal of allergy and clinical immunology.

[8]  W. Thomas,et al.  Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli. , 1988, International archives of allergy and applied immunology.

[9]  S. Zehetmayer,et al.  The performance of a component‐based allergen‐microarray in clinical practice , 2006, Allergy.

[10]  K. Roux,et al.  Tree Nut Allergens , 2003, International Archives of Allergy and Immunology.

[11]  M. Egger,et al.  Panallergens and their impact on the allergic patient , 2010, Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology.

[12]  M. Borres,et al.  Severe reactions after the intake of soy drink in birch pollen‐allergic children sensitized to Gly m 4 , 2011, Acta paediatrica.

[13]  S. Vieths,et al.  Sub‐lingual Immunotherapy: World Allergy Organization Position Paper 2009 , 2009, Allergy.

[14]  M. Borres,et al.  Basophil allergen threshold sensitivity, CD‐sens, IgE‐sensitization and DBPCFC in peanut‐sensitized children , 2012, Allergy.

[15]  R. Valenta,et al.  From allergen genes to allergy vaccines. , 2010, Annual review of immunology.

[16]  I. Swoboda,et al.  Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[17]  P. Schmid‐Grendelmeier,et al.  IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy , 2012, Allergy.

[18]  A. Knulst,et al.  The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model. , 2013, The Journal of allergy and clinical immunology.

[19]  A. Knulst,et al.  Parental anxiety before and after food challenges in children with suspected peanut and hazelnut allergy , 2010, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[20]  A. Ponsonby,et al.  Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. , 2012, The Journal of allergy and clinical immunology.

[21]  D. Ebo,et al.  Young infants with atopic dermatitis can display sensitization to Cor a 9, an 11S legumin‐like seed‐storage protein from hazelnut (Corylus avellana) , 2011, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[22]  M. Lombardero,et al.  Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study , 2008, Allergy.

[23]  D. Ebo,et al.  Component‐resolved diagnosis from latex allergy by microarray , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[24]  R. Valenta,et al.  Recombinant allergens for immunoblot diagnosis of tree-pollen allergy. , 1991, The Journal of allergy and clinical immunology.

[25]  W. Hemmer,et al.  Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins. , 2008, The Journal of allergy and clinical immunology.

[26]  K. Kohno,et al.  Sensitivity and specificity of recombinant ω‐5 gliadin‐specific IgE measurement for the diagnosis of wheat‐dependent exercise‐induced anaphylaxis , 2008, Allergy.

[27]  J. Lidholm,et al.  Prostatic kallikrein: a new major dog allergen. , 2009, The Journal of allergy and clinical immunology.

[28]  G. Viegi,et al.  Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 * , 2008, Allergy.

[29]  P. Gamboa,et al.  A study of the variability of the in vitro component-based microarray ISAC CDR 103 technique. , 2011, Journal of investigational allergology & clinical immunology.

[30]  H. Nelson Specific immunotherapy with allergen mixes: what is the evidence? , 2009, Current opinion in allergy and clinical immunology.

[31]  I. Pali-Schöll,et al.  Anti‐acid medication as a risk factor for food allergy , 2011, Allergy.

[32]  R. Mullins,et al.  Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose. , 2012, The Journal of allergy and clinical immunology.

[33]  H. Malling,et al.  Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis. , 2008, The Journal of allergy and clinical immunology.

[34]  C. Radauer,et al.  Allergens are distributed into few protein families and possess a restricted number of biochemical functions. , 2008, The Journal of allergy and clinical immunology.

[35]  R. Crameri,et al.  Time course of antibody response to recombinant Aspergillus fumigatus antigens in cystic fibrosis with and without ABPA , 2005, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[36]  Wayne Thomas,et al.  Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  M. Ebisawa,et al.  Use of allergen components begins a new era in pediatric allergology , 2011, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[38]  I. Mahillo,et al.  How molecular diagnosis can change allergen‐specific immunotherapy prescription in a complex pollen area , 2012, Allergy.

[39]  H. Akiyama,et al.  A reliable and sensitive immunoassay for the determination of crustacean protein in processed foods. , 2007, Journal of agricultural and food chemistry.

[40]  S. Spector,et al.  Allergen immunotherapy: a practice parameter third update. , 2007, The Journal of allergy and clinical immunology.

[41]  T. Keil,et al.  Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. , 2012, The Journal of allergy and clinical immunology.

[42]  R. Valenta,et al.  Molecular composition and biological activity of commercial birch pollen allergen extracts , 2009, European Journal of Clinical Investigation.

[43]  A. Custovic,et al.  Molecular diagnosis of peanut and legume allergy , 2011, Current opinion in allergy and clinical immunology.

[44]  H. Grönlund,et al.  IgE antibodies to animal‐derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma , 2012, Allergy.

[45]  Yi-Hsing Chen,et al.  Sensitization to Per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan. , 2012, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[46]  B. Niggemann,et al.  Micro‐arrayed wheat seed and grass pollen allergens for component‐resolved diagnosis , 2009, Allergy.

[47]  G. Canonica,et al.  The IgE repertoire in children and adolescents resolved at component level: A cross‐sectional study , 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[48]  R. Van Ree,et al.  Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions , 2008, Current opinion in allergy and clinical immunology.

[49]  P. Matricardi,et al.  Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: implications for specific immunotherapy. , 2012, The Journal of allergy and clinical immunology.

[50]  H. Sampson,et al.  Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age. , 2010, The Journal of allergy and clinical immunology.

[51]  C. Endresen,et al.  Characterization of parvalbumin, the major allergen in Alaska pollack, and comparison with codfish Allergen M. , 2005, Molecular immunology.

[52]  M. Jutel,et al.  Allergen-specific immunotherapy with recombinant grass pollen allergens. , 2005, The Journal of allergy and clinical immunology.

[53]  H. Sampson,et al.  Correlation of IgE and IgG4 Milk Epitopes with Different Clinical Phenotypes of Milk Allergy Using Microarray Immunoassay , 2010 .

[54]  R. Valenta,et al.  Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens. , 1992, International archives of allergy and immunology.

[55]  J. Yagüe,et al.  Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant‐foods and pollens , 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[56]  R. Van Ree,et al.  Sensitization to Cor a 9 and Cor a 14 Is Highly Specific for a Hazelnut Allergy With Objective Symptoms in Dutch Children and Adults , 2014, Pediatrics.

[57]  M. W. Mueller,et al.  Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen‐specific serum immunoglobulin E , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[58]  J. T. Borrego,et al.  Reactividad cruzada entre pescados y mariscos , 2003 .

[59]  Mónica Ruiz-García,et al.  Profilin: a relevant aeroallergen? , 2011, The Journal of allergy and clinical immunology.

[60]  C. Akdis,et al.  Immunological mechanisms of allergen-specific immunotherapy , 2006, Nature Reviews Immunology.

[61]  P. Schmid‐Grendelmeier,et al.  [Recombinant allergens. For routine use or still only science?]. , 2010, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[62]  G. Passalacqua,et al.  The type of sensitizing allergen can affect the evolution of respiratory allergy , 2006, Allergy.

[63]  O. Cromwell,et al.  Recombinant allergens for specific immunotherapy. , 2011, The Journal of allergy and clinical immunology.

[64]  J. Tenenbaum,et al.  Evaluation of microarray surfaces and arraying parameters for autoantibody profiling , 2008, Proteomics.

[65]  J. Lidholm,et al.  Peanut component Ara h 8 sensitization and tolerance to peanut. , 2012, The Journal of allergy and clinical immunology.

[66]  S. Vieths,et al.  Soybean (Glycine max) allergy in Europe: Gly m 5 (beta-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. , 2009, The Journal of allergy and clinical immunology.

[67]  P. Berbis,et al.  Component‐resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy , 2012, Clinical and Experimental Allergy.

[68]  P. Schmid‐Grendelmeier,et al.  Hay fever as a Christmas gift. , 2013, The New England journal of medicine.

[69]  J. Cumplido,et al.  Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. , 2006, The Journal of allergy and clinical immunology.

[70]  R. Valenta,et al.  Recombinant allergen molecules: tools to study effector cell activation , 2001, Immunological reviews.

[71]  B. García,et al.  Comparison of conventional and component-resolved diagnostics by two different methods (Advia-Centaur/Microarray-ISAC) in pollen allergy. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[72]  R. Van Ree,et al.  Profilins: Mimickers of Allergy or Relevant Allergens? , 2011, International Archives of Allergy and Immunology.

[73]  A. Mari,et al.  The Role of Lipid Transfer Proteins in Allergic Diseases , 2010, Current allergy and asthma reports.

[74]  M. Ebisawa,et al.  Clinical Utility of IgE Antibodies to ω-5 Gliadin in the Diagnosis of Wheat Allergy: A Pediatric Multicenter Challenge Study , 2011, International Archives of Allergy and Immunology.

[75]  J. Godbold,et al.  Utility of casein-specific IgE levels in predicting reactivity to baked milk. , 2013, The Journal of allergy and clinical immunology.

[76]  K. Chu,et al.  Current Immunological and Molecular Biological Perspectives on Seafood Allergy: A Comprehensive Review , 2014, Clinical Reviews in Allergy & Immunology.

[77]  P. Schmid-Grendelmeier,et al.  Rekombinante Allergene , 2010, Der Hautarzt.

[78]  H. Sampson,et al.  Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. , 2010, The Journal of allergy and clinical immunology.

[79]  C. Hamsten,et al.  Identification of galactose‐α‐1,3‐galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy , 2013, Allergy.

[80]  Giorgio Walter Canonica,et al.  Allergen immunotherapy: therapeutic vaccines for allergic diseases , 1998 .

[81]  R. Rodriguez-Perez,et al.  Sensitization to serum albumins in children allergic to cow's milk and epithelia , 2007, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[82]  V. Mahler,et al.  Microarrays of recombinant Hevea brasiliensis proteins: a novel tool for the component-resolved diagnosis of natural rubber latex allergy. , 2010, Journal of investigational allergology & clinical immunology.

[83]  N. Rigby,et al.  Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. , 2006, The Journal of allergy and clinical immunology.

[84]  J. Sastre Molecular diagnosis in allergy , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[85]  Crameri,et al.  Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[86]  Niederberger,et al.  The recombinant allergen‐based concept of component‐resolved diagnostics and immunotherapy (CRD and CRIT) , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[87]  A. Nowak‐Wegrzyn,et al.  Molecular diagnosis of egg allergy , 2011, Current opinion in allergy and clinical immunology.

[88]  T. Platts-Mills,et al.  Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. , 2009, The Journal of allergy and clinical immunology.

[89]  D. Ebo,et al.  Sensitization profiles in birch pollen‐allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component‐resolved allergy diagnosis , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[90]  M. Blanca,et al.  Can component‐based microarray replace fluorescent enzimoimmunoassay in the diagnosis of grass and cypress pollen allergy? , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[91]  L. Cox,et al.  Comparison of allergen immunotherapy practice patterns in the United States and Europe. , 2009, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[92]  J. Simon,et al.  Overview of Component Resolved Diagnostics , 2013, Current Allergy and Asthma Reports.

[93]  E. Cavalier,et al.  A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC , 2011, Clinical chemistry and laboratory medicine.

[94]  W. Shreffler,et al.  Microarrayed recombinant allergens for diagnostic testing. , 2011, The Journal of allergy and clinical immunology.

[95]  A. Lopata,et al.  New insights into seafood allergy , 2009, Current opinion in allergy and clinical immunology.

[96]  M. Borres,et al.  Exploring the temporal development of childhood IgE profiles to allergen components , 2012, Clinical and Translational Allergy.

[97]  P. Korošec,et al.  Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. , 2010, The Journal of allergy and clinical immunology.

[98]  R. Valenta,et al.  Component-resolved diagnosis to optimize allergen-specific immunotherapy in the Mediterranean area. , 2007, Journal of investigational allergology & clinical immunology.

[99]  R. Brehler,et al.  Suitability of Different Glycoproteins and Test Systems for Detecting Cross-Reactive Carbohydrate Determinant-Specific IgE in Hymenoptera Venom-Allergic Patients , 2011, International Archives of Allergy and Immunology.

[100]  A. Mari,et al.  Carrier‐bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy , 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[101]  T. Platts-Mills,et al.  The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. , 2011, The Journal of allergy and clinical immunology.

[102]  G. Canonica,et al.  The ImmunoCAP ISAC molecular allergology approach in adult multi-sensitized Italian patients with respiratory symptoms. , 2011, Clinical biochemistry.

[103]  G. Canonica,et al.  The added value of allergen microarray technique to the management of poly-sensitized allergic patients , 2012, Current opinion in allergy and clinical immunology.

[104]  L. Elfman,et al.  Parvalbumin, a cross-reactive fish allergen, contains IgE-binding epitopes sensitive to periodate treatment and Ca2+ depletion. , 1998, The Journal of allergy and clinical immunology.