Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5−/dim B-helper T cell induction

[1]  E. Morand,et al.  Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus , 2016, Nature Medicine.

[2]  N. Tran,et al.  Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells. , 2016, Immunity.

[3]  E. Hamelmann,et al.  Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells , 2016, Nature Communications.

[4]  M. Clementi,et al.  Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment , 2015, Journal of diabetes research.

[5]  H. Hammad,et al.  Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. , 2015, Immunity.

[6]  L. Chatenoud,et al.  Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes , 2015, PloS one.

[7]  Y. Li,et al.  Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner. , 2015, Cellular immunology.

[8]  K. Tenbrock,et al.  Regulatory T cells in systemic lupus erythematosus , 2015, European journal of immunology.

[9]  M. Kubo,et al.  Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers , 2014, The Journal of experimental medicine.

[10]  Maurice Kriegel,et al.  Diet, microbiota and autoimmune diseases , 2014, Lupus.

[11]  Jiajie Zhang,et al.  PEAR: a fast and accurate Illumina Paired-End reAd mergeR , 2013, Bioinform..

[12]  C. Mackay,et al.  Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. , 2013, Immunity.

[13]  R. Rappuoli,et al.  Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses , 2013, Proceedings of the National Academy of Sciences.

[14]  M. Hattori,et al.  Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota , 2013, Nature.

[15]  T. So,et al.  Homeostatic Proliferation of Naive CD4+ T Cells in Mesenteric Lymph Nodes Generates Gut-Tropic Th17 Cells , 2013, The Journal of Immunology.

[16]  M. Hattori,et al.  Robustness of Gut Microbiota of Healthy Adults in Response to Probiotic Intervention Revealed by High-Throughput Pyrosequencing , 2013, DNA research : an international journal for rapid publication of reports on genes and genomes.

[17]  A. Hill,et al.  Both IFN‐γ and IL‐17 are required for the development of severe autoimmune gastritis , 2012, European journal of immunology.

[18]  D. Klatzmann,et al.  Interleukin 21 Correlates with T Cell and B Cell Subset Alterations in Systemic Lupus Erythematosus , 2012, The Journal of Rheumatology.

[19]  Carola G. Vinuesa,et al.  Foxp3(+) follicular regulatory T cells control the germinal centre response , 2012 .

[20]  Gerald McGwin,et al.  Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. , 2012, Arthritis and rheumatism.

[21]  J. Craft,et al.  T cells that promote B‐Cell maturation in systemic autoimmunity , 2012, Immunological reviews.

[22]  髙田 和城 The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells , 2012 .

[23]  S. Sakoda,et al.  The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells , 2011, PloS one.

[24]  A. Cunningham,et al.  B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells , 2011, The Journal of experimental medicine.

[25]  Marcel Martin Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .

[26]  L. Meza-Zepeda,et al.  Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression , 2011, PloS one.

[27]  N. Sarvetnick,et al.  The Incidence of Type-1 Diabetes in NOD Mice Is Modulated by Restricted Flora Not Germ-Free Conditions , 2011, PloS one.

[28]  K. Honda,et al.  Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species , 2011, Science.

[29]  Christophe Benoist,et al.  Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. , 2010, Immunity.

[30]  C. Elson,et al.  Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis , 2010, The Journal of experimental medicine.

[31]  William A. Walters,et al.  QIIME allows analysis of high-throughput community sequencing data , 2010, Nature Methods.

[32]  R. Nurieva,et al.  Bcl6 Mediates the Development of T Follicular Helper Cells , 2009, Science.

[33]  N. Fazilleau,et al.  Follicular helper T cells: lineage and location. , 2009, Immunity.

[34]  W. Leonard,et al.  A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice , 2009, Proceedings of the National Academy of Sciences.

[35]  R. Flavell,et al.  ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity , 2008, The Journal of experimental medicine.

[36]  R. Ley,et al.  Innate immunity and intestinal microbiota in the development of Type 1 diabetes , 2008, Nature.

[37]  G. Tsokos,et al.  Common variable immune deficiency (CVID) presenting as an autoimmune disease: role of memory B cells. , 2008, Autoimmunity reviews.

[38]  Diego G. Silva,et al.  Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA , 2007, Nature.

[39]  H. Ikeshima-Kataoka,et al.  Decreased numbers of signal-joint T cell receptor excision circle-containing CD4+ and CD8+ cells in systemic lupus erythematosus patients , 2007, Modern rheumatology.

[40]  E. Butcher,et al.  The germinal center response is impaired in the absence of T cell‐expressed CXCR5 , 2007, European journal of immunology.

[41]  T. Kanai,et al.  TH1/TH2‐mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice , 2006, Inflammatory bowel diseases.

[42]  Jung Mogg Kim,et al.  Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model. , 2006, Arthritis and rheumatism.

[43]  Eoin L. Brodie,et al.  Greengenes: Chimera-checked 16S rRNA gene database and workbench compatible in ARB , 2006 .

[44]  R. Copley,et al.  A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity , 2005, Nature.

[45]  W. Paul,et al.  Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms , 2005, The Journal of Immunology.

[46]  A. Troy,et al.  Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion1 , 2005, The Journal of Immunology.

[47]  A. Khoruts,et al.  A causal link between lymphopenia and autoimmunity , 2004, Immunology Letters.

[48]  C. Czuprynski Faculty Opinions recommendation of The essential role of the intestinal microbiota in facilitating acute inflammatory responses. , 2004 .

[49]  A. Khoruts,et al.  A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells1 , 2004, The Journal of Immunology.

[50]  N. Sarvetnick,et al.  Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity , 2004, Cell.

[51]  J. Haas,et al.  Thymic Export Function and T Cell Homeostasis in Patients with Relapsing Remitting Multiple Sclerosis1 , 2003, The Journal of Immunology.

[52]  Y. Shoenfeld,et al.  HIV and autoimmunity. , 2002, Autoimmunity reviews.

[53]  J. Miyazaki,et al.  Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression1 , 2002, The Journal of Immunology.

[54]  G. László,et al.  Differential expression of GL7 activation antigen on bone marrow B cell subpopulations and peripheral B cells. , 2001, Immunology letters.

[55]  P. Loetscher,et al.  Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function , 2000, The Journal of experimental medicine.

[56]  E. Kremmer,et al.  Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production , 2000, The Journal of experimental medicine.

[57]  F. Ponchel T cell homeostasis in patients with rheumatoid arthritis , 2000, Arthritis Research & Therapy.

[58]  Fiona Powrie,et al.  Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation , 2000, The Journal of experimental medicine.

[59]  C. Berek,et al.  CXCR5‐deficient mice develop functional germinal centers in the splenic T cell zone , 2000, European journal of immunology.

[60]  Tagami,et al.  Prevention of B220+ T cell expansion and prolongation of lifespan induced by Lactobacillus casei in MRL/lpr mice , 1999, Clinical and experimental immunology.

[61]  P. Gleeson,et al.  Organ‐specific Autoimmunity Induced by Lymphopenia , 1996, Immunological reviews.

[62]  G. Nossal,et al.  FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[63]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[64]  M. Satoh,et al.  Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane , 1994, The Journal of experimental medicine.

[65]  J. Watson,et al.  CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells , 1993, The Journal of experimental medicine.

[66]  S. Behar,et al.  Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice , 1991, The Journal of experimental medicine.

[67]  C. Janeway,et al.  IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. , 1989, Journal of immunology.

[68]  Wharton Gw,et al.  House dust mites. , 1976, Journal of medical entomology.

[69]  T. Sakakura,et al.  Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. , 1970, Science.

[70]  Yijun Carrier,et al.  /J Mice lpr/lpr Lymphocytes in MRL/MpJ-Fas Accumulation of Activated B and T IL-21 Receptor Is Required for the Systemic , 2012 .

[71]  S. Tangye,et al.  Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. , 2010, Arthritis and rheumatism.

[72]  A. Theofilopoulos,et al.  The new paradigm of T-cell homeostatic proliferation-induced autoimmunity. , 2005, Trends in immunology.

[73]  S. Izui,et al.  Genetic basis of murine lupus. , 2004, Autoimmunity reviews.

[74]  W. Paul,et al.  Neonates support lymphopenia-induced proliferation. , 2003, Immunity.

[75]  M. Nussenzweig,et al.  Extrathymic T Cell Lymphopoiesis: Ontogeny and Contribution to Gut Intraepithelial Lymphocytes in Athymic and Euthymic Mice , 2003 .

[76]  E. Tan,et al.  Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. , 1989, Advances in immunology.